931 results about "Nicotinic Acids" patented technology

An improved method and composition for the treatment of hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia as well as other disease states, particularly cardiovascular problems, uses a multiple release system that provides an immediate release of nicotinic acid followed by a subsequent release of nicotinic acid from the hydrolysis of a compound that generates nicotinic acid. In general, a composition according to the present invention comprises: (1) a quantity of nicotinic acid intended to saturate liver enzymes during a period from about 0.5 hours to about 2.5 hours after administration of the pharmaceutical composition but insufficient to trigger significant generation of nicotinuric acid; (2) a quantity of a derivative or analogue of nicotinic acid that is subject to hydrolysis after ingestion such that preferrably no more than about 10% of the derivative or analogue is hydrolyzed by about 8 hours after ingestion and such that substantially all of the derivative or analogue is hydrolyzed by about 12 hours after ingestion; and (3) at least one pharmaceutically acceptable carrier.

The composition for treating hyperlipemia contains one or more nicotinic acids or the derivatives and one or more Tatin compound as 3-hydroxy-3-methyl glutaryl coenzyme inhibitor in the effective amount and the active component weight ratio of 5-100 as well as medicinal supplementary material. The present invention is used in preventing and treating hyperlipemia and has long acting period and high comprehensive treating effect.

The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the GPCR is expressed endogenously by adipocytes. In further preferred embodiments, the GPCR inhibits intracellular lipolysis. In other further preferred embodiments, the GPCR is a nicotinic acid receptor. The present invention also relates to methods of using a modulator of said GPCR. Preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, stroke, insulin resistance, and type 2 diabetes.

A compound having the general structure of Formula (I):or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.

The invention provides health-care food for beautifying and brightening hair of a dog, belonging to the field of animal health-care products. The health-care food formula comprises the following components by weight based on 1kg: 10-30g of deep sea fish oil, 10-30g of linseed oil, 5-20g of poppyseed oil, 10-30g of perilla oil, 10-30g of grape seed oil, 10-30g of lecithin, 5-20g of chelate iron, 1-10g of chelate manganese, 5-20g of chelate zinc, 1-5g of chelate copper, 0.05-0.2g of yeast selenium, 150-250g of methionine, 50-150g of lysine, 1-4g of vitamin E, 0.05-0.2g of vitamin D, 0.5-2g of vitamin A, 0.05-0.2g of vitamin B1, 0.1-0.4g of vitamin B2, 0.05-0.2g of vitamin B6, 0.05-0.4g of vitamin B12, 0.05-0.2g of biotin, 0.1-0.4g of nicotinic acid, 1-5g of bacillus, 1-5g of yeast, 120-180gof chicken liver powder, 50-80g of Rosmarinus officinalis and the balance of yeast powder. The components are made into a tablet with the specification of 0.7-0.9g according to a regular tabletting process, and the water content is less than 10%. The health-care food provided by the invention has the advantages of high titer and strong stability and is capable of improving the fur health of the dog, protecting hair follicles and hair shafts against damage, enabling the hair to be smooth and soft, reducing hair slip, promoting regeneration of furs, improving immunity comprehensively and ensuring the dog in a healthy and vital state.

The invention provides a pig feed for improving growth performance and immunization function of weanling pig, which is characterized by comprising a feed carrier, nicotinic acid, calcium pantothenate, biotin, vitamin C, Lactobacillus lactis, lactobacillus plantarum, amylase, protease, fish oil, zein powder, grease, methionine, tryptophan, threonine, lysine, ethoxy quinoline and a traditional Chinese medicine additive. The traditional Chinese medicine composition is added to the feed to improve the growth performance and immunization function of the weanling pig, thereby promoting the healthy growth of the baby pig.

The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other preferred embodiments, the GPCR is coupled to Gi and lowers the level of intracellular cAMP. In other preferred embodiments, the GPCR is expressed endogenously by adipocytes. In further preferred embodiments, the GPCR inhibits intracellular lipolysis. In other further preferred embodiments, the GPCR is a nicotinic acid receptor. The present invention also relates to methods of using a modulator of said GPCR. Preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, stroke, insulin resistance, and type 2 diabetes.

The invention relates to a fruit and vegetable yogurt drink and a preparation method thereof. The method comprises the following steps: selecting excellent apples, cucumbers, carrots, radishes, aloes, mango, pineapple, yangtao, sweet potatoes, tomatoes and milk; cleaning and processing the raw materials; preparing fruit and vegetable juice, and homogenizing and degassing the fruit and vegetable juice; mixing the fruit and vegetable juice with the milk; fermenting, homogenizing and sterilizing; cooling and bulking; checking and warehousing. The fruit and vegetable yogurt drink disclosed by the invention achieves micro-molecularization after being juiced, can be absorbed by a human body more easily, has the characteristics of being pleasant in sweetness and sourness, comprehensive and abundant in nutrition, and appetizing, contains a plurality of natural mineral substances such as dietary fibers, protein, vitamin B2, vitamin C, vitamin E, superoxide dismutase (SOD), carotene, nicotinic acid, calcium, phosphorus, ferrum, potassium, copper and selenium, is an excellent yogurt drink, and also has the effects of stimulating a digestive system and an inner circulation system, reducing blood pressure, preventing cancers, clearing away heat and toxic materials, inducing saliva and slaking thirst, tonifying spleen and reinforcing the stomach, eliminating toxin and beautifying skin, and preventing blurring of image.

The invention relates to a strength-restoring health-care food and preparation method thereof. The health-care food is made of soybean oligopeptide as main component and polysaccharide, complex vitamines, mineral matter, etc, viz. soybean oligopeptide, high-maltose powder, white granulated sugar, vitamine B1, vitamine B2, vitamine C, vitamine E, nicotinic acid, calcium lactate, potassium chloride, sodium chloride, zinc gluconate, L-carnitine tartrate, anhydrous citric acid, acesulfame-k, and IFF concentrated vanilla. The invention is provided with unique formulation, and can rapidly supplying energy and nutrient, especially protein, for dissipating fatigue, promoting restoration of skeletal muscle, strengthening immunologic function, improving motion ability, rapidly restoring physical strength, etc, thereby it can contribute to health, disease-resistance improvement, and motion score improvement, accordingly, the health-care food can be used for soldiers, sportsmen, moderate or hard physical labors in training or working, and be suitable for acute or chronic fatigue patients to use for a long time.

Compositions, methods, and kits useful for treating hyperlipidemic conditions are provided herein. Such compositions can contain synergizing amounts of nicotinic acid, nicotinamide riboside and / or nicotinic acid metabolites in combination with leucine and / or a leucine metabolite, with or without resveratrol.

The invention discloses a fine feed for rhizomys in a rearing period. The fine feed comprises the following raw materials in percentage by weight: 20%-42% of corn, 12%-18% of soybean meal, 30%-50% of rice bran, 10%-23% of bran, 1%-3% of fish meal, 2% of calcium hydrophosphate, 0.5% of stone dust, 1% of common salt and 1% of premix. One kilogram of premix provides 88 million IU (international units) of VA (vitamin A), 60,000 IU of VE (vitamin E), 325 million IU of VD (vitamin D), 310g of VK (vitamin K), 110g of VB (vitamin B), 220g of VB, 65g of VB, 1220g of VB, 50g of pantothenic acid, 10g of nicotinic acid, 800mg of folic acid, 10g of biotin, 30g of Lys (lysine), 60g of Met (methionine), 30g of potassium, sodium, zinc and the like, and 30g of VC (vitamin C); and the main nutritional levels of the obtained fine feed are that the digestible energy is 2.85-3.01 Mcal / kg, and crude protein is 15.52%-18.07%. The fine feed disclosed by the invention can meet the nutritional requirements of the rhizomys sinensis in the rearing period, has a reasonable formula, and can ensure the rapid growth, robust physique, low disease incidence and low mortality rate of the rhizomys.

The present invention provides a method of administering vitamin B6 related compounds for treatment of hypertriglyceridemia. Vitamin B6 related compounds include pyridoxal, pyridoxal-5′-phosphate, pyridoxamine, a 3-acylated analogue of pyridoxal, a 3-acylated analogue of pyridoxal-4,5-aminal, and mixtures thereof. Embodiments of the present invention also comprise co-administering a lipid lowering agent, such as a nicotinic acid, a fibrate, a HMG CoA reductase inhibitor, a cholesteryl ester transfer protein inhibitor, and combinations thereof.

Belonging to the premix field, the invention relates to an additive premix for laying hens. The premix of the invention mainly contains: soybean meal, calcium hydrogen phosphate, stone powder, salt, compound vitamin, nicotinic acid, D-calcium pantothenate, biotin, choline chloride, copper sulfate, ferrous sulfate, zinc sulfate, manganese sulfate, potassium iodide premix, sodium selenite premix, ethoxy quinoline, phytase, microecologics, xylo oligosaccharide, bentonite and rice husk. With xylo oligosaccharide and a plurality of probiotics and without antibiotic, the premix in the invention hasa reasonable formula and high viable bacteria content. Animal feeding experiments prove that the additive premix in the invention has ideal feeding effects. The ammonia concentration, the death and culling rate, and the broken egg rate can be reduced, while the laying rate and egg weight are enhanced. The composite premix provided in the invention can well promote the laying performance and health status of laying hens, and meet the needs of mass raising households, and is suitable for green and healthy culture so as to produce pollution-free egg products.

The present invention belongs to the field of feed technology, and is especially tortoise and turtle feedstuff and its preparation process. The feedstuff is prepared with soybean, rough fish, vegetable, alpha-starch, pre-mixed material, vitamin B6, vitamin B12, nicotinic acid, vitamin C, cod-liver oil, enzyme preparation, garlicin and Yingjining in certain proportion, and through mixing. The feedstuff of the present invention has high benefit, high tortoise and turtle growth speed, low cost, obvious disease resisting effect and high bioavailability.

The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt); it also relates to therapeutic methods that utilize Nampt inhibitors in combination with NAD biosynthesis precursors to intentionally kill cancer cells while limiting or minimizing toxicity to normal host cells; and it relates to methods of identifying cancers that will be most responsive to treatment with Nampt inhibitors, particularly when administered in combination with nicotinic acid.

The invention a bletilla striata differentiation and seedling strengthening medium and relates to the technical field of bletilla striata planting and cultivation. The bletilla striata differentiation and seedling strengthening medium is prepared from the following raw materials including potassium nitrate, 440-490mg of ammonium sulfate, monopotassium phosphate, magnesium sulfate, calcium chloride, manganese sulfate, zinc sulfate, boric acid, potassium iodide, sodium molybdate, copper sulfate, cobalt chloride, ferrous sulfate, EDTA (Ethylene Diamine Tetraacetic Acid), phaseomannite, thiamine sulfate, pyridoxine sulfate, nicotinic acid, glycine, DMPT, sodium para-nitrophenolate, sodium ortho-nitrophenol, 5-nitroguaiacol sodium salt, 6-BA, NAA, PP-333, CPPU, citric acid, and cane sugar under a proper pH value condition. The bletilla striata differentiation and seedling strengthening medium can improve the differentiation effects of bletilla striata seeds, and promotes the growth of seedlings and the fast formation of pseudobulb, so that the germination rate of the seeds can be effectively increased, and the growth speed of an embryoid can be increased.

The invention relates to an osmotic pump controlled release pharmaceutical composition which contains two medicine active ingredients and is used for treating hyperlipoidemia and a preparation method thereof, the pharmaceutical composition has a nicotinic acids medicine such as acipimox and the other one estatina medicine such as atorvastatin; wherein, the nicotinic acids medicine such as acipimox is a controlled release part, and the estatina medicine such as atorvastatin is a quick release part; or both the acipimox and the atorvastatin are the controlled release part. The compound osmotic pump preparation of the invention has the advantages of comprehensive action, low toxicity and side effects and convenient use.

The invention discloses a preparation method of 4-trifluoromethyl nicotinic acid, and relates to a preparation method of a compound, which comprises the following steps: taking 4,4,4-trifluoroacetoacetate and cyanoacetamide as raw materials, taking potassium hydroxide as a catalyst to obtain 2,6-dihydroxy-3-cyano-4-trifluoromethyl pyridine by cyclization, then using POCl3 to chloridize to obtain 2,6-chloro-3-cyano-4-trifluoromethyl pyridine, and finally carrying out Pd / C catalytic hydrogenolysis or hydrogenolysis and then hydrolyzing or hydrolyzing and then carrying out Pd / C catalytic hydrogenolysis to obtain the target product 4-trifluoromethyl nicotinic acid. The invention provides a feasible and safe preparation method of the 4-trifluoromethyl nicotinic acid, which has certain economic advantages and can be applied to industrial production.

Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts and their active ingredients, including species of mushrooms and mycelia containing psilocybin and psilocin, combined with erinacines and hericenones or fungal extracts containing those active ingredients, with the addition of nicotinic acid. The compositions may optionally be combined with nervine plants.

Belonging to the premix field, the invention provides a compound premix able to improve the immune function for pigs. The premix mainly comprises: ferrous sulfate, copper sulfate, zinc sulfate, manganese sulfate, potassium iodide, cobalt chloride, sodium selenite, organic trace elements, multiple vitamins, pantothenic acid, nicotinic acid, folic acid, biotin, lysine, a compound microecological preparation, ethoxy quinoline, 50% of choline chloride, zeolite powder and wheat bran. Without any antibiotic, the premix of the invention has a rational formula, contains a variety of probiotics and isof high live bacteria content. Animal feeding experiments prove that the premix has ideal feeding effects of high pig survival rate, fast weight gain and improved feed conversion efficiency. Being conducive to improve the intestinal microenvironment of pigs, maintain intestinal health, improve the immune function of pigs, reduce the occurrence of diseases and promote pig growth, the premix provided in the invention can satisfy the demands of vast raising households, and is suitable for developing green and healthy breeding as well as producing pollution-free livestock products.

The invention relates to fine finish for grains, in particular to fine and further processing for rice, which especially relates to a fortified rice that is produced by coating the nutrient components on the rice surface by adopting film coating equipment for continuous and quantitive coating and by taking starch or dextrin as an adhesive, as well as a processing technique thereof. In the method, the rice is prepared by adding the certain nutrient components as follows: nicotinic acid, folic acid, vitamin A, B1, B2, E, calcium, ferrum, zinc, magnesium, selenium and spirulina. The invention has the advantages of convenient processing, low cost and high efficiency; the obtained fortified rice has the advantages of natural color, balanced nutrient components and stable quality.

The invention relates generally to the field of industrial microbiology and alcohol production. More specifically, the invention relates to the use of thiamine, biosynthetic precursors of thiamine, nicotinic acid, nicotinamid, nicotinic acid riboside, nicotinamid riboside, or other biosynthetic precursors of nicotine adenine dinucleotide (NAD) to improve butanol production. Butanol production can be improved by providing sufficient amounts of thiamine, biosynthetic precursors of thiamine, nicotinic acid, nicotinamid, nicotinic acid riboside, nicotinamid riboside, or other biosynthetic precursors of nicotine adenine dinucleotide (NAD) in the production media.

The invention provides malic acid-production gene engineering bacteria Escherichiacoli BA043. The malic acid-production gene engineering bacteria is named as BA043 (Escherichiacoli BA043) and has a preservation registration number CCTCC NO: M2014034. The invention also provides a construction method of the malic acid-production gene engineering bacteria and a method for fermentation production of malic acid. Through knockout or inactivation of fumarase and fumarate reductase and through over coexpression of exogenous pyruvate carboxylase and nicotinic acid phosphoribosyl transferase, recombinant escherichia coli can reduce by-product pyruvic acid generation by glucose metabolism growth so that a malic acid yield and production intensity are greatly improved.

Compositions for addressing one or more of the effects of aging are described. The compositions comprise a first component comprising repair system activator(s) such as nicotinamide adenine dinucleotide (NAD+), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine mononucleotide (NaMN), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid riboside (NAR), 1-methylnicotinamide (MNM), cyclic adenosine monophosphate (cAMP) and combinations thereof; a second component comprising methyl donor(s), such as S-5'-adenosyl-L-methionine (SAM), methionine, betaine, choline, folate, vitamin B12, or combinations thereof; and a third component comprising antioxidant defense activators, such as H2O2, N2S, NaSH, Na2S, and several others, including combinations thereof.Methods of administering the disclosed compositions or separate formulations of repair system activator, methyl donors, and antioxidant defense activators are also disclosed.

The disclosure provides derivatives of both the oxidized form and the reduced form of nicotinamide riboside (NR) and nicotinic acid riboside (NAR). The NR and NAR derivatives have improved stability and bioavailability compared to NR and NAR, and can increase cellular NAD+ levels and improve mitochondrial function. Therefore, the NR and NAR derivatives are useful for treating mitochondrial diseases, mitochondria-related diseases and conditions, and other disorders and conditions.

The invention discloses milk powder for improving children intelligence, which is prepared from the following raw materials: 0.1 to 2 grams of docosahexaenoic acid (DHA) microcapsule, 1 to 4 grams of arachidonic acid (AA), 1 to 6 grams of soy protein, 1 to 4 grams of soybean lecithin, 0.1 to 1 gram of taurine, 10 milligrams to 2 grams of zinc gluconate, 1 to 20 grams of instant walnut powder and 61 to 95.79 grams of milk powder. The milk powder contains sufficient protein, trace elements such as multiple amino acids, AA, DHA, carbohydrate, inorganic salt, calcium, iron, zinc, magnesium, manganese, copper and the like, carotene, thiamine, vitamin B2, vitamin E, nicotinic acid and the like, so the milk powder has very rich nutrient components, has the effects of enhancing cell viability, improving cranial nerve function, improving the dysfunction and disorder of the neural system, preventing hypomnesis and the like and is particularly suitable to be used by the children needing to improve the memory.

An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treating hyperlipidemia in a hyperlipidemic having a substantially periodic physiological loss of consciousness, includes the steps of forming a composition having an effective antihyperlipidemic amount of nicotinic acid and a time release sustaining amount of a swelling agent. The method also includes the step of orally administering the composition to the hyperlipidemic once per day “nocturnally,” that is in the evening or at night.

The invention discloses a multivitamin mineral effervescent tablet which comprises the following components in parts by mass: 60-80 parts of ferrous gluconate, 50-70 parts of zinc gluconate, 0.03-0.08 part of sodium selenite, 0.08-1.6 parts of vitamin B1, 0.08-1.6 parts of vitamin B2, 0.08-1.5 parts of vitamin B6, 70-90 parts of vitamin C, nicotinic acid, pantothenic acid, folic acid, organic acid, carbon dioxide source, acid particle binder, lubricant, alkali particle filler, corrigent, microcrystalline cellulose, fruit powder and sorbitol. The multivitamin mineral effervescent tablet contains multiple mineral matters and multiple vitamins and is a multivitamin mineral effervescent tablet with the combination of multiple vitamins and mineral matters. The invention further discloses a preparation method of the multivitamin mineral effervescent tablet.

The invention relates to medicament containing nicacid or other Statin drugs, which is a double layer tablet, one of which contains clinically effective dose nicacid and slow release preparation findings acceptable in pharmaceutics, while the other layer contains clinically effective dose Statin drugs and slow release preparation findings acceptable in pharmaceutics.

The invention relates to the technical field of animal feed, in particular to a compound pre-mixed material for dairy cows in the post-perinatal period and application thereof. The compound pre-mixed material consists of iron sulfate, manganese sulfate, zinc sulfate, copper sulfate, 1-percent potassium iodide, 1-percent cobalt sulfate, 1-percent sodium selenite, vitamin A, vitamin D, vitamin E, glucose, coated choline, rumen bypass fat, nicotinic acid, vitamin C, yeast cultures, organic chromium, dihydropyridine, sodium bicarbonate, and a carrier. The compound pre-mixed material can be safely and conveniently used, obviously improve an effective conception rate and oestrus rate of the dairy cows, reduce non-pregnant days of the dairy cows, shorten a claving interval of the dairy cows, enforce the body recovery of the dairy cows after delivery, lowers a culling ratio of the dairy cows, prolong a use period of the dairy cows, improve a feeding level of the dairy cows, and increase economic benefits of dairy cow farmers; and the compound pre-mixed material also has the advantages of easy source of raw materials, lower cost, obvious effect, easy popularization and wide application prospect, and is specially used for feeding the dairy cows in the post-perinatal period.