The invention relates to the technical field of animal feed, in particular to a compound pre-mixed material for dairy cows in the post-perinatal period and application thereof. The compound pre-mixed material consists of iron sulfate, manganese sulfate, zinc sulfate, copper sulfate, 1-percent potassium iodide, 1-percent cobalt sulfate, 1-percent sodium selenite, vitamin A, vitamin D, vitamin E, glucose, coated choline, rumen bypass fat, nicotinic acid, vitamin C, yeast cultures, organic chromium, dihydropyridine, sodium bicarbonate, and a carrier. The compound pre-mixed material can be safely and conveniently used, obviously improve an effective conception rate and oestrus rate of the dairy cows, reduce non-pregnant days of the dairy cows, shorten a claving interval of the dairy cows, enforce the body recovery of the dairy cows after delivery, lowers a culling ratio of the dairy cows, prolong a use period of the dairy cows, improve a feeding level of the dairy cows, and increase economic benefits of dairy cow farmers; and the compound pre-mixed material also has the advantages of easy source of raw materials, lower cost, obvious effect, easy popularization and wide application prospect, and is specially used for feeding the dairy cows in the post-perinatal period.