The invention belongs to the field of pesticides, and relates to a mixed herbicide composition containing bispyribac-sodium and quinclorac. The herbicide composition adopts the bispyribac-sodium and the quinclorac as main active components, the weight ratio of the bispyribac-sodium and the quinclorac is 1 to 99:1 to 99, and different surfactants, thickening agents, solvents, solid fillers or the like can be added to the herbicide composition to become a variety of agents, such as emulsifiable concentrate, suspending agents, water-dispersible granules, wettable powder and the like. The herbicide composition can prevent and get rid of annual gramineous weeds, broadleaf weeds and cyperaceous weeds in paddy fields, and compared with single agents, the herbicide composition delays the resistance of weeds under the premise that the pesticide effect is enhanced, has a broad weeding spectrum and long persistence, is safe for rice and next-stubble crops, and therefore is an ideal paddy field herbicide.