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36 results about "Hippuric acid" patented technology
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Hippuric acid (Gr. hippos, horse, ouron, urine) is a carboxylic acid and organic compound. It is found in urine and is formed from the combination of benzoic acid and glycine. Levels of hippuric acid rise with the consumption of phenolic compounds (such as fruit juice, tea and wine). The phenols are first converted to benzoic acid, and then to hippuric acid and excreted in urine.
Analyte injection system
InactiveUS20050133370A1Increase in sizeShort amount of timeSludge treatmentVolume/mass flow measurementGlutaric acidAntibody conjugate
This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.
Owner:WAKO PURE CHEMICAL INDUSTRIES +1
Fluorescent probe based on MOF, preparation method and application of same
ActiveCN107746705AHigh fluorescence emission efficiencyGood fluorescence stabilityFluorescence/phosphorescenceLuminescent compositionsN-HydroxysuccinimideFluorescence sensor
The invention provides a fluorescent probe based on MOF, a preparation method and an application of same, belongs to the technical field of fluorescence sensors, and is used for solving problems detection of concentration of hippuric acid in the prior art has complex operations, long time consumption and low sensitivity. The preparation method includes the steps of: A) adding metal ions, containing Al<3+>, and 2-aminoterephthalic acid to deionized water, uniformly mixing and stirring the solution, performing a reaction at 120-160 DEG C to prepare MOF solid powder; B) adding the MOF solid powder, carboxylated calix[4]arene, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide to deionized water, and stirring the liquid to produce the fluorescent probe based on MOF. The invention also provides an application of the fluorescent probe based on MOF as a fluorescence sensor in detection of hippuric acid. The fluorescent probe has high fluorescent emitting efficiency and good fluorescent stability, is convenient and quick to use in detection and has high sensitivity and good stability.
Owner:JILIN UNIV
Synthesis of PET imaging agent prosome isoquinoline methanamide derivant
InactiveCN101429161AReduce pollutionSimple processOrganic chemistryRadioactive preparation carriersStable Isotope LabelingBenzaldehyde
The invention discloses a synthetic method for an isoquinoline formamide derivative of PET developer precursor, and belongs to the field of synthesis of stable isotope labeled precursor. The method is as follows: a) glycin and o-chlorobenzoyl chloride with proper molar ratio are subjected to acylation reaction under alkaline environment to obtain 2-chloro hippuric acid; b) the 2-chloro hippuric acid obtained in step a) and benzaldehyde are subjected to cyclization reaction under appropriate temperature, and proper amount of catalyst is added into the mixture for molecule rearrangement to obtain 1-(2-chlorpheyl)isoquinoline-3-methanoic acid; and c) the 1-(2-chlorpheyl) isoquinoline-3-methanoic acid reacts with halogeno reagent and then is ammonolyzed to obtain a compound as general formula (I). The synthetic method has the advantages that the synthetic method shortens synthetic route, reduces synthetic cost, is simple, convenient and practical, and has higher yield.
Owner:CHANGSHU INSTITUTE OF TECHNOLOGY
Method for quick screening angiotemsin invertase inhibitor combined using high effieient liquid chromatograph and mass spectrum
InactiveCN1831529AEasy to operateQuick analysisComponent separationMicrobiological testing/measurementBlood plasmaBiology
A method of using high efficiency chromatograph and mass spectrum unitedly to quickly screen inhibitor of angiotonin converzyme uses hippuric acid bialkyd as substrate and uses purified rabbit lung angiotonin converzyme as source of angiotonin converzyme for carrying out quick analysis on vitality of angiotonin converzyme in human blood plasma.
Owner:HUNAN NORMAL UNIVERSITY
Kit for separating and identifying campylobacter rectus as well as preparation and application for kit
InactiveCN102816831AValid identificationEasy to identifyMicrobiological testing/measurementAgainst vector-borne diseasesCulture mediumsCampylobacter jejuni
The invention relates to a kit for separating and identifying campylobacter rectus as well as a preparation and an application for the kit, and mainly solves technical problems of high omission factor, complex identifying steps, higher cost and insufficiently visualized screened results in the existing method for separating the campylobacter rectus, such as campylobacter jejuni and non campylobacter jejuni. The kit for separating and identifying the campylobacter rectus has the technical scheme that: the kit comprises a selective enrichment broth I, a selective enrichment broth II, an improved Karmali agar plate, a Columbia blood plate, a microaerophilic gas generation bag, a gram staining solution, an oxidase reagent, a hippuric acid paper sheet and a hippuric acid enzyme reaction reagent. The campylobacter jejuni or non campylobacter jejuni is identified through a reaction combination test of a substrate and a typical colonial morphologic, simple biochemical and specific enzyme of the campylobacter rectus correspondingly grown in a culture medium for selective separation.
Owner:SHANGHAI MUNICIPAL CENT FOR DISEASE CONTROL & PREVENTION
Organic fertilizer
InactiveCN106278741AImprove qualityImprove fertilityCalcareous fertilisersExcrement fertilisersDiseasePhosphate
The invention discloses an organic fertilizer. The organic fertilizer comprises the following raw materials in parts by weight: 30-40 parts of emissions from flocks and herds, 20-30 parts of plant ash, 20-25 parts of Protein paste, 5-10 parts of dried pine needle, 10-14 parts of amino acid humic acid, 5-8 parts of hippuric acid, 3-7 parts of phosphate, 5-15 parts of dolomite, 11-13 parts of natural zeolite, 4-9 parts of medical stone, 12-15 parts of bean dregs, 6-8 parts of peanut shells, 4-9 parts of sawdust, 5-10 parts of urea, 3-5 parts of biological fungi, 2-3 parts of a strain powder, and 0.5-1 part of microelement. The organic fertilizer provided by the invention can increase production, improve soil, prevent diseases and restrain bacteria, and also can resist stress and remove hazards, the raw material cost is low, no residue can be left, organic nutrients are taken as the major part, and an appropriate amount of an inorganic fertilizer is reasonably proportioned, so that not only can full and reasonable nutrients be provided for crops, but also soil quality can be comprehensively improved, the soil fertility is increased, the manurial effect is quick and durable, fertilizer damage cannot be caused, and comprehensive and balanced nutrients can be provided for crops. In the formula, various trace elements and beneficial strains are provided, and the organic fertilizer provided by the invention not only can be taken as a good fertilizer source, but also can serve as a soil conditioner.
Owner:安徽省样样红农业发展有限公司
Detection method of angiotensin converting enzyme (ACE) inhibitory activity of antihypertensive peptide
InactiveCN102608234AAvoid the phenomenon of low accuracyImprove accuracyComponent separationBoronic acidHypotensive peptide
A detection method of angiotensin converting enzyme (ACE) inhibitory activity of antihypertensive peptide comprises the following steps that: firstly, boric-acid buffer solution is prepared to perform an experiment on ACE activity inhibition of the antihypertensive peptide; secondly, reaction products are detected and analyzed by LC-MC (liquid chromatography-mass spectrometry), and the antihypertensive activity of the antihypertensive peptide is represented by detecting change of peak area of hippuric acid (Hip), wherein the purity of the Hip is ensured through monitoring of an HPLC (high performance liquid chromatography) ultraviolet detector and an electrospray ion source mass spectrum as well as with adoption of a total ion chromatogram and an ultraviolet detection chromatogram, and the peak area of the Hip is calculated by quantitatively analyzing the Hip peak area of an ion extract diagram of m / z180 in an SIM model; and thirdly, the peak area of the Hip of the reaction products in a reaction group and a no-treatment control group are obtained through the first and second steps, thereby obtaining the ACE inhibition ratio of a sample. In the method, the LC-MS technology is applied to screening activity of the antihypertensive peptide, so that the influence of impurities on activity detection is reduced; and the detection method has the characteristics of being high in precision, good in repeatability and high in sensitivity.
Owner:THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
Prediction method for lipidosis
InactiveUS20070166829A1Improve accuracyHigh sensitivityDisease diagnosisBiological testingPhenylacetylglutaminePhenylalanine
The present invention provides a prediction method for lipidosis caused by a compound, which comprises detecting (a) phenylacetylglycine and / or phenylacetylglutamine, or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to phenylacetylglycine or phenylacetylglutamine, and (b) hippuric acid or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to hippuric acid, in a sample collected from a mammal receiving the compound or a mammalian cell or tissue culture exposed to the compound, and predicting the compound's potential for inducing lipidosis with the quantitative ratio of the two as the index. The present invention also provides a diagnostic method for lipidosis and diseases related thereto, comprising detecting (a) and (b) above in a sample collected from a mammal, and making a diagnosis with the quantitative ratio of the two as the index.
Owner:TAKEDA PHARMA CO LTD
Method for detecting benzene, methylbenzene and xylene metabolin in urine
ActiveCN109342633AMonitor Exposure LevelsReduce distractionsComponent separationBenzenePhenylmercapturic Acid
The invention discloses a method for detecting benzene, methylbenzene and xylene metabolins in urine. The method comprises the following steps: (1) mixing urine with a first solvent, centrifuging so as to obtain supernate, mixing the supernate with a second solvent so as to obtain a first sample liquid, and detecting a first generation of metabolin in the first sample liquid through a liquid chromatogram tandem mass spectrum, wherein the first generation of metabolin comprises phenylmercapturic acid acid S-PMA, 8-hydroxy-2-deoxyguanosine 8-OHdG, 2-methyl hippuric acid 2-MHA, 3-methyl hippuricacid 3-MHA and 4-methyl hippuric acid 4-MHA; and (2) mixing a part of the first sample liquid with a third solvent so as to obtain a second sample liquid, detecting a second generation of metabolin through the liquid chromatogram tandem mass spectrum, wherein the second generation of metabolin comprises hippuric acid HA. By adopting the method disclosed by the invention, more than six metabolins can be detected in a combined manner.
Owner:THE BEIJING PREVENTION & TREATMENT HOSPITAL OF OCCUPATIONAL DISEASE FOR CHEM IND
Hard capsules with enteric film coating
ActiveCN103417380ADelay the time of deterioration of renal functionReduce poisonDigestive systemCarbon active ingredientsDiseaseHard Capsule
The present invention provides a hard capsule with enteric film coating, which is a particular advantage of the sealing structure and the enteric film coating composition coated hard gelatin capsules, hard gelatin capsules so that the enteric film coating in the stomach and small intestine with complete shape, but may disintegrate in the large intestine and the release point of the hard capsule shell activated carbon, thereby selectively adsorbing the pro-protein small molecule compounds such as indole, indoxyl sulfate, p-cresol, hippuric acid and the like. Further, the resultant film-coated hard gelatin capsules may be enteric prevention or treatment of a liver disease or kidney disease a pharmaceutical composition.
Owner:CHENHO PHARMA
Prediction method for lipidosis
InactiveUS7399638B2Improve accuracyHigh sensitivityDisease diagnosisBiological testingDiseasePhenylacetylglutamine
The present invention provides a prediction method for lipidosis caused by a compound, which includes detecting (a) phenylacetylglycine and / or phenylacetylglutamine, or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to phenylacetylglycine or phenylacetylglutamine, and (b) hippuric acid or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to hippuric acid, in a sample collected from a mammal receiving the compound or a mammalian cell or tissue culture exposed to the compound, and predicting the compound's potential for inducing lipidosis with the quantitative ratio of the two as the index. The present invention also provides a diagnostic method for lipidosis and diseases related thereto, including detecting (a) and (b) above in a sample collected from a mammal, and making a diagnosis with the quantitative ratio of the two as the index.
Owner:TAKEDA PHARMA CO LTD
Composition and antibacterial application thereof
ActiveCN113995744AGuaranteed stabilityReduced liquidityAntibacterial agentsBiocideBiotechnologyHuman body
The invention relates to a composition and antibacterial application thereof. The composition is applied to a human body and an environment where the human body is located so as to reduce the reproduction trend of microorganisms existing in the human body, and comprises one or more of malic acid, hippuric acid, fumaric acid, glycine, succinic acid, L-valine and citric acid.
Owner:温州丽恩生物科技有限公司
Applications of set of amino acid marker in acute kidney injurydiagnostic kit
InactiveCN108956790ARealize quantitative analysisExcellent diagnostic abilityComponent separationDiseaseCreatinine rise
The invention belongs to the field of disease diagnostic kit, and more specifically relates to applications of a set of amino acid markers in preparation of an acute kidney injury (AKI) diagnostic agent or a kit. The amino acid marker is one or a composition of two selected from kynurenine, hippuric acid, and pidolic acid. The AUC values of the three amino acid markers in independent diagnosis ofacute kidney injury at acute renal injury early stage diagnosis are all larger than 0.7, the diagnosis distinguish effect is excellent. The diagnosis capacities of kynurenine and hippuric acid are better than that of clinically used renal function marker creatinine and early stage diagnosis marker NGAL; the diagnosis time of the above three amino acids on AKI is earlier than that of clinically used renal function marker urea nitrogen. The invention also provides a targeting amino acid metabonomic detection method capable of realizing quantitative analysis of a plurality of amino acids at the same time, the sensitivity is high, and the results are accurate and reliable.
Owner:SECOND AFFILIATED HOSPITAL SECOND MILITARY MEDICAL UNIV
Pleuromutilin hippuric acid ester with antibacterial activity and a method of preparing the same
ActiveUS11117859B1Organic compound preparationOrganic chemistry methodsResistant bacteriaMicrobiology
A compound with anti-drug resistant bacteria activity having the following formula(I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.
Owner:SHAANXI UNIV OF SCI & TECH
Method for detecting methyl hippuric acid in urine
The invention provides a method for detecting methyl hippuric acid in urine. The method comprises the following steps: taking a urine sample, adding parachlorobenzoic-acid, hydroquinone and 3,4-dihydroxyphenylanaline into the urine sample, and oscillating, mixing and centrifuging; then adding a hydrochlric solution, sodium chloride and ethyl acetate into a supernatant obtained through centrifugation, and oscillating, mixing and centrifuging; then conducting rotary evaporation on a supernatant obtained through centrifugation; finally, adding residues obtained in the step 3 into distilled water, concentrating by nanofiltration, and conducting efficient liquid phase analysis on the concentrated solution. The method provided by the invention is high in sensitivity, precision and recovery rate, and excellent in stability; all methodological indexes conform to related requirements of Guide for Establishing Occupational Health Standards Part 5-Method for Detecting Chemical Substances in Biomaterials; the method provided by the invention can be used for detecting 3 isomers of methyl hippuric acid in urine of both occupational workers exposed to dimethylbenzene and non-occupational people exposed to dimethylbenzene.
Owner:DONGCHEN LEADER TESTING
Method for simultaneously detecting concentrations of glycollic acid and hippuric acid in human urine
The invention relates to a method for simultaneously detecting concentrations of glycollic acid and hippuric acid in human urine. The method comprises: collecting a sample, preparing the sample, drawing a standard curve, performing ion chromatography-conductivity analysis on the sample, calculating the concentration of glycollic acid or hippuric acid in human urine and the like. According to the method, a solid-phase extraction method is adopted to separate and purify hippuric acid and glycollic acid in urine, and an ion chromatography-conductivity detection method is adopted to determine theconcentrations of the glycollic acid and the glycollic acid in actual urine. The method can simultaneously detect the concentrations of glycollic acid and hippuric acid in human urine, is sensitive indetection, rapid in analysis, good in repeatability, simple in operation, accurate and reliable, and can provide a good method reference for analysis and detection of hippuric acid and glycollic acidin actual urine.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
Biomarker and diagnostic kit for distinguishing prostatitis and prostatic cancer
PendingCN114487216AImprove accuracyImprove diagnostic accuracyComponent separationMethyl palmoxirateGlutamic acid
The invention relates to a biomarker and a diagnostic kit for distinguishing prostatitis and prostatic cancer. The biomarker is selected from at least one of citric acid, L-pyroglutamic acid, DL-3-phenyl lactic acid, ethyl malonic acid, 3-hydroxy-3-methyl glutamic acid and hippuric acid. The kit comprises a reagent for quantitatively detecting the biomarker. The biomarker has differential expression in bodies of patients with prostatitis and prostatic cancer, and the difference has statistical significance. ROC curve analysis is further carried out, the result shows that the biomarker can serve as a specific marker for distinguishing prostatitis and prostatic cancer patients, the accuracy is high (AUC ranges from 0.7 to 0.9), especially citric acid, the AUC reaches up to 0.926, and it is indicated that the diagnosis accuracy is high. The invention provides a new biomarker for identifying prostatitis and prostatic cancer patients, and has the advantages of convenience in sampling, rapidness and high efficiency in detection and the like when being used for clinical auxiliary diagnosis.
Owner:广州市番禺区中心医院
Colon cancer diagnostic markers and their application
The invention discloses a colon cancer diagnostic marker and its application. The colon cancer diagnostic marker is a urine metabolite, including pseudouridine, N 2 ,N 2 ‑Dimethylguanosine, Kynurenine, Valine, N‑Acetyl‑L‑Valine, N‑Acetyl‑L‑Glutamate, 5‑Hydroxytryptophan, α,β‑ At least one of didehydrotryptophan, hippuric acid, aspartyl-phenylalanine, taurine, pantothenic acid, 2,3-pyridinedicarboxylic acid, 4-pyridoxic acid, L-carnitine, xanthine , based on the markers, the present invention also provides a colon cancer detection kit, which can effectively distinguish colon cancer patients from healthy people, with high accuracy, strong sensitivity and specificity. The sample selected in the present invention is a urine sample, preferably the middle part of fasting morning urine, which avoids the use of invasive samples such as tissue and blood, and has high patient compliance and clinical application value.
Owner:CHINA PHARM UNIV
Molecular sensor capable of singly and selectively identifying picric acid molecules and synthesis and application of molecular sensor
The invention discloses a synthesis method for synthesizing a molecular sensor capable of singly and selectively identifying picric acid molecules, wherein the synthesis method comprises the steps: carrying out a reaction on 1,8-naphthalic anhydride and hexamethylenediamine as substrates in an ethanol solvent to obtain a naphthalimide derivative; taking trimesoyl chloride and the naphthalimide derivative as substrates, and carrying out a reaction in dichloromethane to obtain the target molecular sensor. DMF solutions of hydrochloric acid, acetic acid, n-butyric acid, salicylic acid, hippuric acid, phenylhydrazine-4-sulfonic acid and p-hydroxybenzoic acid are respectively added into a DMF-H2O solution of the molecular sensor, and only picric acid is added to quench the fluorescence of the DMF-H2O solution of the molecular sensor, so that the single selective identification performance on picric acid is realized, and the detection is quick and sensitive.
Owner:NORTHWEST NORMAL UNIVERSITY
Monoclonal antibody for hippuric acid antigen
InactiveUS20090227777A1Higher competitive inhibitionEngineer specificityImmunoglobulins against animals/humansRecombinant DNA-technologyMetaboliteProtein L
Owner:IND ACADEMIC CORP FOUND YONSEI UNIV +1
Monoclonal antibody for hippuric acid antigen
InactiveUS7816498B2Engineer specificityEngineer affinityImmunoglobulins against animals/humansRecombinant DNA-technologyCross linkerCarrier protein
Owner:IND ACADEMIC COOP FOUND DANKOOK UNIV +1
A method for simultaneously detecting the concentrations of glycolic acid and hippuric acid in human urine for non-disease diagnosis purposes
The invention relates to a method for simultaneously detecting the concentrations of glycolic acid and hippuric acid in human urine for non-disease diagnosis purposes. The method includes: sample collection, sample preparation, standard curve drawing, and ion chromatography-conductivity analysis and calculation on the sample. Steps such as the concentration of glycolic acid or hippuric acid in human urine. The method adopts solid-phase extraction method to separate and purify hippuric acid and glycolic acid in urine, and adopts ion chromatography-conductivity detection method to determine the concentrations of glycolic acid and hippuric acid in actual urine. The method can simultaneously detect the concentrations of glycolic acid and hippuric acid in human urine, and has the advantages of sensitive detection, rapid analysis, good repeatability, simple operation, accurate and reliable method, and can provide analysis and detection of hippuric acid and glycolic acid in actual urine. A good method reference.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
Method for quick screening angiotemsin invertase inhibitor combined using high effieient liquid chromatograph and mass spectrum
InactiveCN100434917CEasy to operateQuick analysisComponent separationMicrobiological testing/measurementBlood plasmaBiology
Owner:HUNAN NORMAL UNIVERSITY
Healthy aging diagnosis marker and application
InactiveCN111380979AImprove accuracyHigh sensitivityComponent separationBiological testingMethoxyacetic acidArginine
The invention discloses a healthy aging diagnosis marker and application thereof. The marker is prepared from one or more of alpha-N-phenylacetyl-L-glutamine, 4-methylphenol, N6-methyladenosine, N1-methyl-2-pyridone-5-carboxamide, 3-phenyllactic acid, 5-hydroxyindoleacetic acid, dopamine, 4-hydroxyphenylpyruvic acid, propionylglycine, 4-aminohippuric acid, indoxyl sulfate, 3,4-dihydroxybutyric acid, O-acetylserine, N2,N2-dimethyl guanosine, N-ticagrelor glycine, threitol, methoxyacetic acid, indole-3-pyruvic acid, L-histidine, homoarginine and arachidonic acid. The marker has the characteristics of high accuracy and high sensitivity, and can be directly used as an index for healthy aging.
Owner:KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
Effective heat treatment method for identifying and quarantine fruit flies and application thereof
PendingCN114740134APrevent intrusionComponent separationAgainst vector-borne diseasesSaccharic acidMetabolite
The invention relates to the technical field of bioinformatics, in particular to an effective heat treatment method for identifying and quarantine fruit flies and application thereof. The method comprises the following steps: identifying quarantine fruit flies and non-quarantine fruit flies according to the difference of the content of metabolites; the metabolite comprises tyrosine, 3-hydroxykynurenine, 4-hydroxyhippuric acid, adenylic acid, dopa, trehalose, malic acid, homoserine, glucose, fumaric acid, yellow uric acid, mannitol, succinic acid, inositol, threonic acid, pinocembriose, uric acid, methionine, serine, oleic acid, stearic acid, palmitoleic acid, glycolic acid, glycine, palmitic acid, putrescine, lactic acid and aminomalonic acid. The compound is one or more of beta-hydroxybutyric acid, alpha-hydroxyglutaric acid, sedoheptulose-7-phosphoric acid or adenosine. The invention provides a plurality of markers which can be used for identifying and quarantine the fruit flies and can effectively distinguish whether the fruit flies are subjected to heat treatment or not.
Owner:CHINESE ACAD OF INSPECTION & QUARANTINE +1
Organic fertilizer for increasing cotton yield and preparation method thereof
InactiveCN107151155AIncrease productionImprove qualityCalcareous fertilisersBio-organic fraction processingTrace element compositionPhosphate
The invention belongs to the technical field of plant fertilizer processing, and provides an organic fertilizer for increasing the cotton yield and a preparation method thereof. The organic fertilizer is prepared from the following raw materials in parts by weight: 10-18 parts of natural potassium-magnesium sulfate, 2-10 parts of hippuric acid, 11-20 parts of dolomite, 10-12 parts of phosphate, 2-5 parts of sweet potato seedlings, 0.1-5 parts of a trace element composition, 2-6 parts of natural attapulgite, 13-14 parts of chicken manure, 10-20 parts of sawdust, 11-14 parts of bran hulls, 0.5-1 part of ferrous sulfate and 1.1-1.5 parts of an organic fertilizer synergist. The organic fertilizer for increasing the cotton yield provided by the invention can improve the cotton yield and quality, and has the advantages of simple components, easily available raw materials, low cost, simple operation, economical and practical properties, effectiveness and stability of iron, and the like.
Owner:合肥市风达农业有限责任公司
A kind of mof-based fluorescent probe and its preparation method and application
ActiveCN107746705BHigh fluorescence emission efficiencyGood fluorescence stabilityFluorescence/phosphorescenceLuminescent compositionsFluoProbesCarboxyl radical
Owner:JILIN UNIV
Method for the detection of benzene, toluene and xylene metabolites in urine
ActiveCN109342633BMonitor Exposure LevelsReduce distractionsComponent separationMetaboliteFluid phase
Owner:THE BEIJING PREVENTION & TREATMENT HOSPITAL OF OCCUPATIONAL DISEASE FOR CHEM IND
A kind of urotropine hippurate composition and preparation method thereof
ActiveCN108186585BSolubleNot easy to absorb moistureAntiinfectivesUrinary disorderHexamethylenetetramineFreeze-drying
The invention discloses a methenamine hippurate composition and a preparation method thereof. According to the method, methenamine hippurate and pharmaceutically acceptable dissolving solvents and bonding agents are mixed and are then subjected to freeze drying; dry granulation is adopted; after flow aids are added, tableting is performed. The preparation is a tablet which is not provided with a coating; under the conditions of not needing special dampproof auxiliary materials and not needing special dampproof packages, through the treatment in the preparation process, the preparation has reinforced dampproof performance; the product friability is improved; high stability and controllability are realized; the methenamine hippurate composition is applicable to large-scale production and issuitable for the final use by a user.
Owner:HUNAN MINGRUI PHARMA
Synthesis methods of deuterine, hippuric acid-L-menthol ester (2,2-D2) and intermediates thereof
PendingCN108358803ASimple stepsEasy to operateOrganic compound preparationCarboxylic acid amides preparationDistillationSynthesis methods
The invention discloses synthesis methods of deuterine, hippuric acid-L-menthol ester (2,2-D2) and intermediates thereof, wherein the synthesis method includes the steps: (1) carrying out a reaction of glycine with a deuterium aqueous solution of alkali metal deuterium oxide under the action of pyridoxal or salts thereof, to obtain a deuterated reaction solution; and (2) recycling a part of deuterium water from the deuterated reaction solution obtained in the step (1) through reduced pressure distillation, then adding water and benzoyl chloride, carrying out an amidation reaction, and after the end of the reaction, posttreating to obtain hippuric acid (2,2-D2). The raw materials and reagents used in the synthesis method are cheap and easy to obtain, and the operation is simple; the purityand the deuterium abundance of the obtained deuterated reagents are high.
Owner:CHANGSHA BEITA PHARMATECH CO LTD
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