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Composition and antibacterial application thereof

A composition and microbial technology, applied in the field of medicine, can solve the problems of undiscovered, citric acid can not achieve antibacterial efficiency, etc., to achieve the effect of reducing fluidity and ensuring stability

Active Publication Date: 2022-02-01
温州丽恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing organic acids are diverse, and the antibacterial effect of citric acid cannot reach the highest antibacterial efficiency among them.
[0005] In the prior art, the antibacterial and antiseptic effects of various weak acids have been confirmed, but the application of organic acids targeting the inhibition of Escherichia coli and Staphylococcus aureus, which have the most extensive and frequent impact on human diseases, has not been found

Method used

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  • Composition and antibacterial application thereof
  • Composition and antibacterial application thereof
  • Composition and antibacterial application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Antibacterial tests were carried out based on the minimum inhibitory concentration method (MIC), and the above antibacterial metabolites were used for Escherichia coli (E.coli; Escherichia coli) and Staphylococcus aureus (S.aureus; Staphylococcus aureus), Pseudomonas aeruginosa The minimum inhibitory concentration (MIC; Minimum Inhibitory Concentration) detection of P.aeruginosa; Pseudomonas aeruginosa) and Serratia marcescens (S.marcescens; Serratiamarcescens).

[0029] (1) Experimental materials:

[0030] 1) culture medium

[0031] Lysogeny Broth (LB; Lysogeny Broth) medium containing 10 g / L peptone, 5 g / L yeast extract and 10 g / L sodium chloride was used.

[0032] 2) Antibacterial drugs:

[0033] The whole composition comprising one or more of fumaric acid, succinic acid, L-valine, malic acid, citric acid, glycine and hippuric acid.

[0034](2) The steps of antibacterial test are as follows:

[0035] 1) Preparation of bacterial suspension

[0036] The preserved ...

Embodiment 2

[0089] This embodiment is a further improvement on Embodiment 1, and repeated content will not be repeated here.

[0090] Take the Liyan Tablet currently used in the treatment of chronic pharyngitis as an example. For chronic pharyngitis caused by bacterial infection, Liyan Tablets can have a better effect on the disease. The ingredients of Liyan Tablets include pangolin (manufactured), wood beetle, silkworm, oyster (calcined), and scrophulariaceae. The pangolin (made) in the ingredients is taken from endangered organisms. This ingredient is a banned drug, so Liyan Tablets cannot be used. Treat patients as prescription or over-the-counter medicines. The present invention explores the inhibitory effect of pangolin scales on bacterial flora, especially Escherichia coli and Staphylococcus aureus, and finds one or more groups of compositions that have effective inhibitory effects on Escherichia coli and Staphylococcus aureus. The main components of the medicine include: one or m...

Embodiment 3

[0092] This embodiment is a further improvement on Embodiment 1 or Embodiment 2, and repeated content will not be repeated here.

[0093] The composition is also used in various foods as an additive composition to effectively inhibit Escherichia coli and Staphylococcus aureus in foods. For example, adding it to some natural fruit juices increases the natural flavor through the ratio of malic acid and citric acid, and cooperates with the fruit juice in vacuum or sealed packaging to achieve antiseptic effect by inhibiting the growth of Escherichia coli and Staphylococcus aureus. The main components of the additive include: one or more of malic acid, hippuric acid, fumaric acid, glycine, succinic acid, L-valine and citric acid. Malic acid and citric acid alone or in combination create a fruity flavored additive.

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Abstract

The invention relates to a composition and antibacterial application thereof. The composition is applied to a human body and an environment where the human body is located so as to reduce the reproduction trend of microorganisms existing in the human body, and comprises one or more of malic acid, hippuric acid, fumaric acid, glycine, succinic acid, L-valine and citric acid.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition and its antibacterial application. Background technique [0002] Pangolin is used in the "Xianfang Huomingyin" in "Women's Prescription" written by Chen Ziming in the Song Dynasty. The effects of the whole prescription include clearing away heat and detoxification, reducing swelling and ulceration, promoting blood circulation and relieving pain, etc., and local redness, swelling, heat and pain. . Li Shizhen’s "Compendium of Materia Medica" in the Ming Dynasty records that pangolin "eliminates phlegm, malaria, cold and heat, wind numbness, rigidity and pain, dredges the meridians, relieves pain and swelling, expels pus and blood, clears the orifice and kills insects." Its "attached prescription" mentions "diarrhea and dysentery", Divide pangolin and clam powder into equal parts, stir fry and grind into powder. It can be seen from the above records in ancient medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A23L3/3508A23L3/3526A61K8/362A61K8/365A61K8/44A01N37/36A01N37/44A01N37/46A01N37/06A01P1/00C11D3/48A61P1/02A61P31/04A61Q11/00
CPCA61K31/194A61K31/197A61K31/198A61P31/04A61P1/02A61K8/362A61K8/44A61K8/365A61Q11/00A23L3/3526A23L3/3508A01N37/36A01N37/44A01N37/46A01N37/06C11D3/48A23V2002/00A61K2300/00A23V2250/044A23V2250/032A23V2250/036A23V2250/0622A23V2250/0654A01P1/00A01N37/04C11D7/265C11D7/3263C11D7/3245A61Q17/005A23L2/44Y02A50/30
Inventor 朱绍和陈丽宋坤坪田雪晨
Owner 温州丽恩生物科技有限公司
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