Medicine-carrying contact lens and preparation method thereof
A contact lens and drug-carrying technology, applied in pharmaceutical formulations, glasses/goggles, drug combinations, etc., can solve the problems of poor tolerance, easy loss of eye drops, etc., and achieve the effect of simple preparation process and delayed release
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0048] The invention relates to a preparation method of a drug-loaded contact lens. The polymerization monomer, a crosslinking agent, a monosubstituted cyclodextrin monomer and an initiator are uniformly mixed, injected into a mold, and cured by ultraviolet light or heating, and then immersed in the The unreacted monomer is removed in a solvent to obtain a cross-linked polymer hydrogel contact lens, which is then soaked in an aqueous solution of drug molecules with a concentration of 0.01% to 10%.
[0049] The invention relates to a preparation method of a drug-loaded contact lens. The polymerized monomer, a crosslinking agent, a monosubstituted cyclodextrin monomer, an initiator and a diluent are uniformly mixed, injected into a mold, and cured by ultraviolet light or heating, and demolded. Then immersed in a solvent to remove unreacted monomers to obtain a cross-linked polymer hydrogel contact lens, which is then soaked in an aqueous solution of a drug with a concentration of...
Embodiment 1
[0068] Weigh 1g monomer HEMA, add the above-mentioned monosubstituted vinyl cyclodextrin monomer GMA-EDA-CD according to the ratio of Table 1, add 0.3% (monomer total weight) of ethylene glycol dimethacrylate (EGDMA ) is a crosslinking agent, 0.4% of Darocur 1173 is used as an initiator, stirred evenly, and after vacuum degassing, add it to a polypropylene contact lens mold at a wavelength of 365nm and an intensity of 30mW / cm 2 Cured under the ultraviolet light for 30 minutes, opened the mold, put it in warm water to remove the film, and then extracted the unreacted monomer to obtain the hydrogel contact lens.
[0069] The prepared hydrogel contact lenses were characterized, and the cyclodextrin-containing hydrogel contact lenses had good light transmission properties, with a water content of 40% to 60%. The relevant mechanical properties are shown in the following table:
[0070] Table 1 Cyclodextrin content and mechanical properties in contact lenses
[0071]
Embodiment 2
[0073] Weigh 0.5g of HEMA, 0.5g of NVP, add 0.0824g of methyl acrylate, 0.33g of the above monosubstituted vinyl cyclodextrin monomer GMA-EDA-CD, add 0.0039g of ethylene glycol dimethacrylate, 0.4 Wt.% Darocur 1173 is used as an initiator, stirred evenly, and vacuum degassed, then added to a polypropylene contact lens mold with a wavelength of 365nm and an intensity of 30mW / cm 2 Cured under ultraviolet light for 30 minutes, opened the mold, put it in warm water to remove the film, extracted unreacted monomers, and obtained hydrogel contact lenses. Hydrogel contact lenses containing cyclodextrin have good light transmission performance and a water content of 65%. .
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com