Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine-carrying contact lens and preparation method thereof

A contact lens and drug-carrying technology, applied in pharmaceutical formulations, glasses/goggles, drug combinations, etc., can solve the problems of poor tolerance, easy loss of eye drops, etc., and achieve the effect of simple preparation process and delayed release

Inactive Publication Date: 2009-01-14
SOUTHEAST UNIV
View PDF7 Cites 30 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The main dosage form of ophthalmic medicine is eye drops or eye ointment. In order to overcome the disadvantages of poor tolerance of eye drops that are easy to lose in the eyes and eye ointment affects vision, etc., gel-type preparations, intraocular implants and Drug-loaded contact lenses, contact lenses used to load drugs to treat eye diseases have been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine-carrying contact lens and preparation method thereof
  • Medicine-carrying contact lens and preparation method thereof
  • Medicine-carrying contact lens and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0048] The invention relates to a preparation method of a drug-loaded contact lens. The polymerization monomer, a crosslinking agent, a monosubstituted cyclodextrin monomer and an initiator are uniformly mixed, injected into a mold, and cured by ultraviolet light or heating, and then immersed in the The unreacted monomer is removed in a solvent to obtain a cross-linked polymer hydrogel contact lens, which is then soaked in an aqueous solution of drug molecules with a concentration of 0.01% to 10%.

[0049] The invention relates to a preparation method of a drug-loaded contact lens. The polymerized monomer, a crosslinking agent, a monosubstituted cyclodextrin monomer, an initiator and a diluent are uniformly mixed, injected into a mold, and cured by ultraviolet light or heating, and demolded. Then immersed in a solvent to remove unreacted monomers to obtain a cross-linked polymer hydrogel contact lens, which is then soaked in an aqueous solution of a drug with a concentration of...

Embodiment 1

[0068] Weigh 1g monomer HEMA, add the above-mentioned monosubstituted vinyl cyclodextrin monomer GMA-EDA-CD according to the ratio of Table 1, add 0.3% (monomer total weight) of ethylene glycol dimethacrylate (EGDMA ) is a crosslinking agent, 0.4% of Darocur 1173 is used as an initiator, stirred evenly, and after vacuum degassing, add it to a polypropylene contact lens mold at a wavelength of 365nm and an intensity of 30mW / cm 2 Cured under the ultraviolet light for 30 minutes, opened the mold, put it in warm water to remove the film, and then extracted the unreacted monomer to obtain the hydrogel contact lens.

[0069] The prepared hydrogel contact lenses were characterized, and the cyclodextrin-containing hydrogel contact lenses had good light transmission properties, with a water content of 40% to 60%. The relevant mechanical properties are shown in the following table:

[0070] Table 1 Cyclodextrin content and mechanical properties in contact lenses

[0071]

Embodiment 2

[0073] Weigh 0.5g of HEMA, 0.5g of NVP, add 0.0824g of methyl acrylate, 0.33g of the above monosubstituted vinyl cyclodextrin monomer GMA-EDA-CD, add 0.0039g of ethylene glycol dimethacrylate, 0.4 Wt.% Darocur 1173 is used as an initiator, stirred evenly, and vacuum degassed, then added to a polypropylene contact lens mold with a wavelength of 365nm and an intensity of 30mW / cm 2 Cured under ultraviolet light for 30 minutes, opened the mold, put it in warm water to remove the film, extracted unreacted monomers, and obtained hydrogel contact lenses. Hydrogel contact lenses containing cyclodextrin have good light transmission performance and a water content of 65%. .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a drug-loaded contact lenses and a corresponding preparation method. The drug-loaded contact lenses are obtained firstly through UV-curing or heat-curing and then through drug-liquid immersion. The drug-loaded contact lenses can be particularly defined as a combination of a contact lenses material containing cyclodextrin and drug molecules and comprise the contact lenses formed by combining a crosslinked polymer hydrogel formed by copolymerizing mono-substituted cyclodextrin monomers, polymerization monomers and crosslinkers with one kind or a plurality of acetazolamide, methazolamide, puerarin or prostaglandin. The characteristic of forming inclusion compounds between the cyclodextrin molecules and drug molecules is adopted to increase the quantity of loaded drugs so as to reduce the stimulation to eyes by drugs and control the drug release speed for eye diseases of curing glaucoma, etc.

Description

technical field [0001] The invention relates to a drug-loaded contact lens and a preparation method thereof, which is characterized in that the drug-loaded contact lens is obtained through ultraviolet light or heat-initiated curing, and the drug-loaded contact lens is obtained by soaking in a drug solution. Specifically, in the present invention, single-substituted cyclodextrin molecules are introduced into contact lens materials, and the ability of cyclodextrin molecules to form clathrates with drug molecules is utilized to increase drug loading and control the release rate of drugs. It is especially suitable for ocular administration of lipophilic drugs, drugs with strong eye irritation and drugs with poor stability, and used to treat eye diseases such as glaucoma. Background technique [0002] At present, soft contact lenses are mainly divided into hydrophilic contact lenses and high oxygen permeability contact lenses. Hydrophilic contact lenses mainly use poly-2-hydroxy...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G02C7/04G02B1/04C08L51/02C08L51/00C08K5/46C08K5/1545C08K5/09C08J3/20A61K47/48A61K31/222A61K31/4178A61K31/433A61K31/573A61K31/5575A61K38/13A61P27/02A61P27/06A61K47/61A61K47/69
Inventor 李新松徐金库
Owner SOUTHEAST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com