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30results about How to "Subject is at risk" patented technology

Ventilatory assistance for treatment of cardiac failure and Cheyne-Stokes breathing

Method and apparatus for the treatment of cardiac failure, Cheyne Stokes breathing or central sleep apnea are disclosed. A subject is provided with ventilatory support, for example positive pressure ventilatory support using a blower and mask. Respiratory airflow is determined. From the respiratory airflow are derived a measure of instantaneous ventilation (for example half the absolute value of the respiratory airflow) and a measure of longterm average ventilation (for example the instantaneous ventilation low pass filtered with a 100 second time constant). A target ventilation is taken as 95% of the longterm average ventilation. The instantaneous ventilation is fed as the input signal to a clipped integral controller, with the target ventilation as the reference signal. The output of the controller determines the degree of ventilatory support. Clipping is typically to between half and double the degree of support that would do all the respiratory work. A third measure of ventilation, for example instantaneous ventilation low pass filtered with a time constant of 5 seconds, is calculated. Ventilatory support is in phase with the subject's respiratory airflow to the fuzzy extent that this ventilation is above target, and at a preset rate conversely.
Owner:RESMED LTD

Ventilatory assistance for treatment of cardiac failure and cheyne-stokes breathing

Method and apparatus for the treatment of cardiac failure, Cheyne Stokes breathing or central sleep apnea are disclosed. A subject is provided with ventilatory support, for example positive pressure ventilatory support using a blower and mask. Respiratory airflow is determined. From the respiratory airflow are derived a measure of instantaneous ventilation (for example half the absolute value of the respiratory airflow) and a measure of longterm average ventilation (for example the instantaneous ventilation low pass filtered with a 100 second time constant). A target ventilation is taken as 95% of the longterm average ventilation. The instantaneous ventilation is fed as the input signal to a clipped integral controller, with the target ventilation as the reference signal. The output of the controller determines the degree of ventilatory support. Clipping is typically to between half and double the degree of support that would do all the respirator work. A third measure of ventilation, for example instantaneous ventilation low pass filtered with a time constant of 5 seconds, is calculated. Ventilatory support is in phase with the subject's respiratory airflow to the fuzzy extent that this ventilation is above target, and at a preset rate conversely.
Owner:RESMED LTD

Method for identifying objects in a subject's ear

InactiveUS20150351606A1Avoid risk of injuryRequirement to deform the subject's ear is eliminated or greatly reducedBronchoscopesLaryngoscopesObservation pointOptical axis
A method of identifying objects in a subject's ear, comprising the following steps: introducing an optical electronic imaging unit and a light source into an ear canal of a subject's outer ear, wherein the electronic imaging unit exhibits an optical axis directed in a distal direction, especially directed at the eardrum of the subject's ear; using the electronic imaging unit to capture an image from an eccentric observation point positioned on the optical axis and positioned eccentrically within the ear canal; and determining brightness or color information to identify objects shown in the image by electronic means, in order to automatically identify the objects, especially the eardrum.
Owner:HELEN OF TROY LIMITED

Dynamic hormone index as a biomarker for disease

The present invention relates, at least in part, to the novel discovery that hormone dynamics are predictive of an individual's risk of developing hormone-associated conditions such as cancer, metabolic syndrome X (MSX), obesity, stress, diabetes and symptoms of aging.
Owner:QUEENS UNIV OF KINGSTON

Method For Suppressing And Reversing Epileptogenesis

A method for identifying, suppressing, and reversing epileptogenesis, which is considered to be a learned response due to brain plasticity. The method includes identifying three epileptogenic conditions, neuronal hyperexcitability, spatial overconnectivity, and temporal overconnectivity. A treatment that accounts for each of these conditions is then be administered to the subject to reverse, or “unlearn,” epilepsy.
Owner:WISCONSIN ALUMNI RES FOUND

MR-proADM as marker for the extracellular volume status of a subject

The present invention relates to a method for determining the extracellular volume status of a subject. The method comprises determining in a sample obtained from a subject the level of the marker proadrenomedullin (proADM) or a fragment thereof, preferably MR-proADM. Further, based on the level of proADM or a fragment thereof, the fluid balance is determined and wherein said fluid balance determines the extracellular volume status. Further, based on the level of proADM or a fragment thereof, the salt balance is determined and wherein said salt balance determines the extracellular volume status and salt retention. Further, the invention relates to a method for in vitro diagnosis, risk stratification, therapy control and / or operative control of a disorder or medical condition in a subject, wherein said extracellular volume status and salt retention of said subject is determined by the herein provided method. Further, the invention relates to a kit and / or a diagnostic device for carrying out the herein provided method.
Owner:BRAHMS GMBH

Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and their use for the prevention or treatment of disease

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.
Owner:ESPERVITA THERAPEUTICS INC

Systems and methods of using machine learning analysis to stratify risk of spontaneous preterm birth

The present disclosure relates to systems and methods of using machine learning analysis to stratify the risk of spontaneous preterm birth (SPTB). In some variations, to select informative markers that differentiate SPTB from term deliveries, a processed quantification data of the markers can be subjected to univariate receiver operating characteristic (ROC) curve analysis. A Differential Dependency Network (DDN) can then applied in order to extract co-expression patterns among the markers. In order to assess the complementary values among selected markers and the range of their relevant performance, multivariate linear models can be derived and evaluated using bootstrap resampling.
Owner:NX PRENATAL INC

Method for the selective determination of placental growth factor 2

The present invention relates to an immunoassay method for placental growth factor 2 (PlGF-2) detection in pregnant subjects. Furthermore the invention relates to the use of said method for the diagnosis, prognosis, risk assessment and therapy control of prenatal disorders comprising the determination of the level of PlGF-2 in said pregnant subjects.
Owner:CEZANNE

Acss2 inhibitors and methods of use thereof

The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity / weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory / autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.
Owner:METABOMED LTD

Poster holder

The present invention relates to a poster holder (10,10′,10″,10′″,1000) comprising a support (3,3′,3″,3*, 3000) intended to be suspended on a wall and provided with at least one engagement seat (6, 600,6″,6*,6′″) and with a bar (4,4′,4″) comprising in turn a fixed length lower portion (18, 18′,18″) comprising a gripping device for engaging an edge of a poster (5) and at least one slider (11,11′,11″,11′″,1100) slidably associated to said lower portion (18, 18′,18″), said slider (11,11′,11″,11′″,1100) being insertable into said engagement seat (6, 600,6″,6*,6′″) such to make a connection between said support (3,3′,3″,3*) and said bar (4, 4′,4″).
Owner:NEW RAINBOW

Method for sampling an egg

The present invention relates to a method for sampling an egg, the method comprising;a) fluid coupling an interior of the egg to a source of pressure,b) controlling the pressure in the interior of the egg by the source of pressure,c) expelling an amount of fluid, in particular allantoic fluid, from the interior of the egg to the exterior of the egg as a result of the pressure in the interior of the egg, andd) collecting at least a portion of the amount of fluid at the exterior surface of the egg.
Owner:SELEGGT GMBH

Devices and methods for suppression of sympathoexcitation

InactiveUS20110190834A1Subject is at riskSuppressing sympathoexcitationHeart defibrillatorsHeart stimulatorsSudden cardiac deathElevated heart rate
The present invention relates to devices and methods for suppression of sympathoexcitation and / or sudden cardiac death. In particular the present invention provides devices and methods which prevent sympathoexcitation and / or sudden cardiac death through an elevated heart rate stimulus.
Owner:NORTHWESTERN UNIV

Protein c pathway associated polymorphisms as response predictors to activated protein c or protein c-like compound administration

The invention provides methods, nucleic acids, compositions and kits for predicting a subject's response to treatment with activated protein C or protein C like compound to identify subjects having a greater benefit from treatment with activated protein C. The method generally comprises determining a protein C pathway associated gene polymorphism genotype(s) of a subject for one or more polymorphisms in the these genes, comparing the determined genotype with known genotypes for the polymorphism that correspond with an improved response polymorphism to identify potential subjects having an inflammatory condition who are more likely to benefit from treatment with activated protein C or protein C like compound and subsequent to treatment recover from the inflammatory condition. The invention also provides for methods of treating such subjects with an anti-inflammatory agent or anti-coagulant agent based on the subject's genotype.
Owner:RUSSELL JAMES A +1

Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor

This invention provides tablets comprising gemcabene calcium salt hydrate Crystal Form 2 or gemcabene calcium salt hydrate Crystal Form C3, each having a PSD90 ranging from 35 μm to 90 μm as measured by laser light diffraction and wherein the tablet has a gemcabene dissolution profile characterized by a % dissolution profile of at least 80% in pH 5.0 potassium acetate buffer at 37° C.±0.5° C. in no more than 45 minutes as measured by ultra-violet / visible light absorption using a detection wavelength range of 216 nm to 230 nm. This invention further provides gemcabene calcium salt hydrate Crystal Forms 4, 5 and 6. The tablets and gemcabene calcium salt hydrate Crystal Forms 4, 5 and 6 are useful for treating or preventing liver disease or an abnormal liver condition, a disorder of lipoprotein or glucose metabolism, a cardiovascular or related vascular disorder, a disease caused by fibrosis (such as liver fibrosis), or a disease associated with inflammation (such as liver inflammation).
Owner:NEUROBO PHARMA INC

Poster holder

The present invention relates to a poster holder (10,10′,10″,10′″,1000) comprising a support (3,3′,3″,3*, 3000) intended to be suspended on a wall and provided with at least one engagement seat (6, 600,6″,6*,6′″) and with a bar (4,4′,4″) comprising in turn a fixed length lower portion (18, 18′,18″) comprising a gripping device for engaging an edge of a poster (5) and at least one slider (11,11′,11″,11′″,1100) slidably associated to said lower portion (18, 18′,18″), said slider (11,11′,11″,11′″,1100) being insertable into said engagement seat (6, 600,6″,6*,6′″) such to make a connection between said support (3,3′,3″,3*) and said bar (4, 4′,4″).
Owner:NEW RAINBOW

Acss2 inhibitors and methods of use thereof

The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity / weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory / autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.
Owner:METABOMED LTD

Method for encoding and decoding data by varying the distinctive characteristics of an optical radiation, encoding device and decoding system

Encoding element (100) at least selectively transparent to an infrared or ultraviolet light radiation, incident thereon on a first incidence surface (101), wherein—in the volume defined by said encoding element (100)—a plurality of areas (104) is provided, previously selected and arranged according to a predefined pattern wherein at least one polarisation characteristic of the optical radiation (200) that is incident thereon is varied, wherein the variation of said polarisation characteristic of said incident radiation is varied according to a localised alteration pattern biunivocally associated to a predefined ciphering key, and wherein said plurality of areas is arranged between said first incidence surface (101) on which said infrared or ultraviolet light radiation is incident in use, and a second output surface (102) of said infrared or ultraviolet light optical radiation.
Owner:SLUX SAGL
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