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85 results about "Stearidonic acid" patented technology
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Stearidonic acid (SDA) is an ω-3 fatty acid, sometimes called moroctic acid. It is biosynthesized from alpha-linolenic acid by the enzyme delta-6-desaturase. Natural sources of this fatty acid are the seed oils of hemp, blackcurrant, corn gromwell, and Echium plantagineum, and the cyanobacterium Spirulina. SDA can also be synthesized in a lab. A GMO soybean source is approved by the European Food Safety Authority.
Pharmaceutical preparation comprising eicosapentaenoic acid and/or stearidonic acid
A pharmaceutical preparation for the treatment of schizophrenia and / or tardive dyskinesia using an oil comprising eicosapentaenoic acid (EPA) and / or stearidonic acid (SA) in amounts of more than 20%, preferably more than 40% and very preferably more than 70% by weight of the total (preferably of the total unsaturated) fatty acids present.
Owner:SCARISTA
Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described.
Owner:EI DU PONT DE NEMOURS & CO
Production of polyunsaturated fatty acids in oleaginous yeasts
The present invention relates to methods for the production of ω-3 and / or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to arachidonic acid (ARA); ETA to eicosapentaenoic acid (EPA); DGLA to ETA; EPA to docosapentaenoic acid (DPA); and ARA to EPA have been introduced into the genome of Yarrowia for synthesis of ARA and EPA.
Owner:DUPONT US HLDG LLC
Production of polyunsaturated fatty acids in oleaginous yeasts
The present invention relates to methods for the production of ω-3 and / or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to arachidonic acid (ARA); ETA to eicosapentaenoic acid (EPA); DGLA to ETA; EPA to docosapentaenoic acid (DPA); and ARA to EPA have been introduced into the genome of Yarrowia for synthesis of ARA and EPA.
Owner:DUPONT US HLDG LLC
Expression of Fatty Acid Desaturases in Corn
ActiveUS20080260929A1High nutritional valueIncrease SDA contentBacteriaPeptide/protein ingredientsStearidonic acidGenetically modified maize
The invention relates generally to the expression of desaturase enzymes in transgenic corn plants and compositions derived therefrom. In particular, the invention relates to the production of oils with improved omega-3 fatty acid profiles in corn plants and the seed oils produced thereby. Such oils may contain stearidonic acid, which is not naturally found in corn plants and has been shown to have beneficial effects on health.
Owner:MONSANTO TECH LLC
Production and use of a polar lipid-rich fraction containing stearidonic acid and gamma linolenic acid from plant seeds and microbes
The production and use, and in particular, the extraction, separation, synthesis and recovery of polar lipid-rich fractions containing gamma linolenic acid (GLA) and / or stearidonic acid (SDA) from seeds and microorganisms and their use in human food applications, animal feed, pharmaceuticals and cosmetics.
Owner:DSM IP ASSETS BV
Aquaculture feed, products, and methods comprising beneficial fatty acids
InactiveUS20090202672A1Improve fatty acid profileGood for healthClimate change adaptationAnimal feeding stuffWarm waterAquatic animal
Embodiments of the present invention provide improved aquaculture products and methods of producing such aquaculture products by incorporating healthier lipids containing stearidonic acid and gamma linolenic acid into the aquaculture feed. This in turn improves the health profile of the aquatic animals promoting growth and limiting commercial losses. Furthermore, embodiments of the present invention provide methods for producing said products. In one embodiment of the invention, an aquaculture animal may be fed a feed comprising a transgenic plant product. In other embodiments of the invention, cold water fish meat, warm water fish meat, and crustacean meat products comprising SDA, GLA, EPA, and DHA are disclosed. In further embodiments of the invention, other aquaculture feed products comprising SDA, and GLA are disclosed.
Owner:MONSANTO TECH LLC
Plant Derived Lipid Useful for Nutraceutical and Cosemeceutical Applications
InactiveUS20080213357A1Discourage complianceUnpleasant tasteCosmetic preparationsBiocideLipid formationMedicine
The present disclosure relates to novel nutritional and cosmeceutical compositions comprising an oil extracted from the seeds of Boraginaceae, particularly Buglossoides arvensis, in the range of from 1 to 100% by weight of the total composition. The oil has particular advantages over oils extracted from other seeds in that the oil is comprised of from 14% to at least 17% stearidonic acid and less than 7% gamma-linolenic acid. The oil composition is particularly suited for oral or topical administration and for dietary, cosmetic, pharmaceutical and healthcare uses.
Owner:TECH CROPS LLC
Composition for accelerated production of collagen
InactiveUS20110130459A1Increased collagen productionIncrease productionBiocideCosmetic preparationsCollagen iStearic acid
Here the inventors provide a composition for topical application to the skin of animal comprising stearidonic acid in combination with one or octadecatrienoic acids (CODTAs). Preferably the composition comprises echium oil as a source of the stearidonic acid, and a plant lipid as a source of octadecatrienoic acid, such as borage oil (Borago officinalis), wheat germ oil (Triticum vulgare) rosehip oil (refined; Rosa mosqueta), jacaranda oil (Jacandra mimosi folia), and / or calendula oil (Calendula officinalis). The composition of the invention increases collagen I secretion and thus has particular utility for promoting collagen production in skin.
Owner:ESLI
Food compositions incorporating additional long chain fatty acids
InactiveUS20090110800A1Good for healthClean flavorMilk preparationClimate change adaptationSide dishPlant Sources
The present invention relates to the improvement of food items through the increased utilization of plant-derived stearidonic acid in a composition that also lowers linolenic acid content. Many long chain fatty acids have been classified as being Omega 3 and have been shown to provide several health benefits, including heart health. According to the current invention plant-derived stearidonic acid (18:4ω3) has been incorporated into a wide range of food products by using a low linolenic acid base composition to enhance stability and shelf life while reducing the need for hydrogenation. The product composition can be used either as an oil oil-based composition or a flour processed from soybeans with enhanced levels of stearidonic acid. These foods range from oil-based products (salad dressing, mayonnaise) to dairy products (milk, cheese) to prepared foods (entrees, side dishes). In addition to improved health benefits the current invention provides food rich in Omega-3 fatty acids that have enhanced storage and / or shelf life characteristics.
Owner:MONSANTO TECH LLC
Treatment and prevention of inflammatory disorders
InactiveUS7163960B2Deleterious effectC-reactive protein is decreasedBiocideSenses disorderRegimenStearidonic acid
The invention relates to methods of treating and preventing disorders associated with elevated TNF-α and / or IL-1β by administering therapeutic amounts of stearidonic acid. Further provided are methods for down-regulating TNF-α and / or IL-1β and assays for determining the presence, absence, or quantity of TNF-α and / or IL-1β in a subject in conjunction with a regimen of stearidonic acid administration.
Owner:ROYAL ADELAIDE HOSPITAL +1
Mixtures of triglycerides of natural polyunsaturated fatty acids with high polyunsaturated fatty acid content, method for producing same and use thereof
A process for increasing the concentration of PUFA triglycerides present in natural PUFA oils, in which a natural PUFA oil having a triglyceride content of more than 85% by weight, based on the total weight of the mixture, and having a total PUFA content of more than 39% by weight of total fatty acids is dissolved in an organic solvent or an organic solvent mixture, the mixture is allowed to stand at a temperature of from −35° C. to −100° C. for a period of more than five minutes, the mixture is separated into a supernatant comprising PUFA-triglyceride mixture and a sediment phase, the separation preferably taking place by filtration or centrifugation, and the solvent or solvent mixture, after the removal of the sediment phase, is separated from the supernatant. PUFA-triglyceride mixtures having a PUFA content of more than 55% by weight of total fatty acids of a main PUFA, or at least two PUFAs selected from stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, gamma-linolenic acid and arachidonic acid, and also use thereof in pharmaceutical, cosmetics and food preparations.
Owner:NUTRINOVA NUTRITION SPECIALTIES & FOOD ENGREDIENTS GMBH
Dietary control of arachidonic acid metabolism
Compositions for the treatment of symptoms of inflammatory disorders may include gamma-linolenic acid or dihomogammalinolenic acid, an inhibitor of Δ5 desaturase, and optionally stearidonic acid or ω-3 arachidonic acid. Preferred formulations may be in the form of a good tasting, preferably milk or fruit based drink, or a dried powder. Compositions reduce inflammation and inhibit increase in serum arachidonic acid associated with gamma-linolenic acid.
Owner:WAKE FOREST UNIV HEALTH SCI INC
Method for the Prevention and Treatment of Cachexia and Anorexia
InactiveUS20070196445A1Lower Level RequirementsEnhanced inhibitory effectBiocidePeptide/protein ingredientsBeta-CaroteneVitamin C
The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of ω-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
Owner:ABBRUZZESE BONNIE CHANDLER +3
Synechocystis efficient double homologous recombinant vector as well as construction method and application thereof
InactiveCN103014053AIncrease contentIncrease total fatty acid contentUnicellular algaeMicroorganism based processesStearidonic acidNucleotide sequencing
The invention particularly relates to synechocystis efficient double homologous recombinant vector as well as a construction method and the application thereof. The nucleotide sequence of the synechocystis efficient double homologous recombinant vector is shown as SEQ ID NO.8 or SEQ ID NO.9. The invention also discloses the construction method and the application of the synechocystis efficient double homologous recombinant vector. The synechocystis efficient double homologous recombinant vector expresses synechocystis PCC6803Delta 15, Delta 15 and Delta 6 fatty acid desaturase gene in synechocystis PCC6803, and can obviously increase the content of therapic acid in synechocystis.
Owner:山东省农业科学院高新技术研究中心
Omega-3 enriched cereal, granola, and snack bars
InactiveUS20100272875A1Improve nutritional qualityNegative tasteDough treatmentEdible oils/fats with fatty acid estersStearidonic acidProduct mix
The present disclosure provides for improved cereal products, specifically snack bars, and methods of producing such products by incorporating healthy lipids containing stearidonic acid into the product compositions. In one embodiment of the disclosure, a cereal product including a SDA-enriched oil is disclosed. In another embodiment of the disclosure, a snack bar including a SDA-enriched soybean oil is disclosed.
Owner:MONSANTO TECH LLC
Fatty acid-containing compositions and methods for the treatment of cytokine mediated disorders
InactiveUS20060052446A1Improve bioavailabilityEasy to manageBiocideAmide active ingredientsDietary supplementCytokine
Compositions, dietary supplements and medical foods for the treatment of symptoms of inflammatory disorders may include gamma-linolenic acid or dihomogammalinolenic acid, an inhibitor of Δ5 desaturase, and optionally stearidonic acid or ω−3 arachidonic acid. Preferred formulations may be in the form of a good tasting, preferably milk or fruit based drink, or a dried powder. Compositions reduce inflammation and inhibit increase in serum arachidonic acid associated with gamma-linolenic acid. The compositions of the invention may also be used for the treatment of cytokine mediated disorders in patients in need thereof.
Owner:PILOT THERAPEUTICS +1
Method for the production of γ-linolenic acid and/or stearidonic acid in transgenic Brassicaceae and Linaceae
ActiveUS8013216B2Sugar derivativesPeptide preparation methodsStearidonic acidNucleic acid sequencing
The present invention relates to the production of γ-linolenic acid (18:3Δ6,9,12) or stearidonic acid (18:4Δ6,9,12,15) or γ-linolenic acid (18:3Δ6,9,12) and stearidonic acid (18:4Δ6,9,12,15) in transgenic plants of the family Brassicaceae, where the transgenic plants comprise at least 10% by weight of oleic acid based on the total fatty acid content and, as the result of the activity of the Δ6-desaturases used in the method, have an increased Δ6-C18-fatty acid content. The invention furthermore relates to novel nucleic acid sequences which code for the Δ6-desaturases used in the method, gene constructs comprising these nucleic acid sequences, a vector and transgenic plants comprising at least one nucleic acid sequence or a gene construct.
Owner:BASF PLANT SCI GMBH
Feedstuffs for Aquaculture Comprising Stearidonic Acid
ActiveUS20090299083A1Improve the level ofSeed and root treatmentFermentationLipid formationCrustacean
The present invention relates to feedstuffs for use in aquaculture, as well as methods for producing said feedstuffs. The invention also provides methods for rearing fish and / or crustaceans. In particular, the present invention provides a method of rearing a fish or crustacean, the method comprising feeding the fish or crustacean a feedstuff comprising lipid, the fatty acid of said lipid comprising at least 5.5% (w / w) stearidonic acid (SDA).
Owner:COMMONWEALTH SCI & IND RES ORG
Food compositions incorporating stearidonic acid
The present invention relates to the improvement of food items through the increased utilization of plant-derived stearidonic acid. Many long chain fatty acids have been classified as being Omega 3 and have been shown to provide several health benefits, including heart health. According to the current invention plant-derived stearidonic acid (18:4ω3) has been incorporated into a wide range of food products by using either oil or flour processed from soybeans with enhanced levels of stearidonic acid. These foods range from oil-based products (salad dressing, mayonnaise) to dairy products (milk, cheese) to prepared foods (entrees, side dishes). In addition to improved health benefits the current invention provides food rich in Omega-3 fatty acids that have enhanced storage and / or shelf life characteristics.
Owner:MONSANTO TECH LLC
Means for improving cardiovascular health
The present invention is in the fields of lipid metabolism and dietary supplementation and provides methods and compositions to improve heart health of a mammal by orally administering stearidonic acid and related compounds to the mammal. The improved heart health is evidenced by the enrichment of cardiac tissue with eicosapentaenoic acid (20:5, ω3) and docosapentaenoic acid (22:5, ω3) following the administration. Also provided are methods for promoting a stearidonic acid containing product by advertising its heart health benefits.
Owner:MONSANTO TECH LLC
Oxidixable fatty acid composition delivery form
The present invention provides a chewable oral delivery vehicle comprising a chewable matrix and at least one soft gelatin capsule encapsulating an oxidizable fatty acid composition, wherein the at least one soft gelatin capsule is incorporated into the chewable matrix. The chewable matrix may be a gummy candy or jelly sweet. The oxidizable fatty acid composition may be a free fatty acid composition, fatty acid ester composition, glyceride composition, phospholipid composition or combinations thereof, and preferably comprise one or more fatty acids or residues thereof selected from the group consisting of eicosapentaenoic-, docosahexaenoic-, docosapentaenoic-, conjugated linoleic-, palmitoleic-, trans palmitoleic-, alpha linolenic-, gamma linolenic-, and stearidonic acid and combinations thereof.
Owner:INNOLIPID
Poultry meat and eggs comprising beneficial fatty acids
The present disclosure provides for improved poultry products and methods of producing such poultry products by incorporating healthy lipids containing stearidonic acid into animal feed products. Furthermore, the present disclosure provides methods for producing said products. In one embodiment of the disclosure, a poultry animal may be fed feed comprising a transgenic plant product. In other embodiments of the disclosure, poultry white meat and dark meat products comprising SDA, EPA, DPA, and DHA are disclosed. In further embodiments of the disclosure, poultry eggs comprising SDA, EPA, DHA, and DPA are disclosed.
Owner:MONSANTO TECH LLC
Omega-3 Fatty Acid Enriched Beverages
InactiveUS20120100257A1Improve nutritional qualitySimilar tasteMilk preparationOrganic chemistryStearidonic acidNutritional quality
The present invention relates to beverage compositions and methods for producing beverage compositions with a quantity of omega-3 fatty acids (n-3 PUFAs). Specifically, the beverage compositions comprise a quantity of stearidonic acid (SDA) enriched soybean oil that imparts improved nutritional quality with a quantity of n-3 PUFAs, but retains the mouthfeel, flavor, odor, and other sensory characteristics associated with typical beverage compositions.
Owner:SOLAE LLC
Dietary Control of Arachidonic Acid Metabolism
InactiveUS20070105957A1Preventing increase in serum AA levelBiocideNervous disorderBiologyDietary control
Compositions for the treatment of symptoms of inflammatory disorders may include gamma-linolenic acid or dihomogammalinolenic acid, an inhibitor of Δ5 desaturase, and optionally stearidonic acid or ω-3 arachidonic acid. Preferred formulations may be in the form of a good tasting, preferably milk or fruit based drink, or a dried powder. Compositions reduce inflammation and inhibit increase in serum arachidonic acid associated with gamma-linolenic acid.
Owner:WAKE FOREST UNIV
Nut butter and related products enriched with omega-3
InactiveUS20120164307A1Good for healthImproved profileFood shapingGrain treatmentsMedicineStearidonic acid
The present disclosure provides for improved nut butter and nut butter spread formulations and methods of producing such formulations by incorporating healthy lipids containing stearidonic acid into the formulations. In one embodiment of the disclosure, a peanut butter formulation including a SDA-enriched oil is disclosed. In another embodiment of the disclosure, a peanut butter spread formulation including a SDA-enriched soybean oil is disclosed.
Owner:MONSANTO TECH LLC
Omega-3 Fatty Acid Enriched Baked Foods and Bar Composition
InactiveUS20120107478A1Clean flavorLong shelf-life stabilityMilk preparationDough treatmentLong chain fatty acidFlavor
The present invention relates to compositions and methods for producing baked food compositions and bar compositions with a quantity of long chain fatty acids. Specifically, the baked food compositions and bar compositions comprise a quantity of stearidonic acid (SDA) enriched soybean oil that imparts improved nutritional quality with an amount of long chain fatty acids, but retains the mouthfeel, flavor, odor, and other sensory characteristics associated with typical baked food compositions and bar compositions.
Owner:SOLAE LLC
Bifidobacterium breve and application thereof in preparation of conjugated fatty acid
ActiveCN110878273AIncrease productionImprove conversion rateBacteriaMicroorganism based processesBiotechnologyMicroorganism
The invention relates to bifidobacterium breve and an application thereof in preparation of conjugated fatty acid, belonging to the technical field of microorganisms. The invention provides bifidobacterium breve FBJCP2M1 capable of producing conjugated linoleic acid, conjugated linolenic acid and conjugated octadecatetraenoic acid, wherein the conversion rate of linoleic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated linoleic acid can reach 87.98%, and the content of the c9,t11-CLA isomer accounts for 98.38% of the content of the conjugated linoleic acid; the conversionrate of linolenic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated linolenic acid can reach 95.6%, and the content of the c9,t11,c15-CLNA isomer accounts for 95.01% of the content of the conjugated linolenic acid; and the conversion rate of octadecatetraenoic acid with the bifidobacterium breve FBJCP2M1 to produce the conjugated octadecatetraenoic acid can reach 55.86%, andthe content of c6,c9,t11,c15-CSA isomer accounts for 90.45% of the content of the conjugated octadecatetraenoic acid.
Owner:JIANGNAN UNIV +1
Oxylipins from stearidonic acid and .gamma.-linolenic acid and methods of making and using the same
InactiveUS7893106B2Relieve symptomsReduce and preventBiocideNervous disorderStearidonic acidOxylipin
Disclosed are novel oxylipins that are derived from γ-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of SDA- and / or GLA-derived oxylipins.
Owner:DSM IP ASSETS BV
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