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78 results about "MS multiple sclerosis" patented technology

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.

Dual action recumbent exercise cycle

A dual action recumbent exercise cycle which provides upper body, lower body and cardiovascular conditioning with emphasis directed toward the needs of obese individuals as well as individuals with equilibrium issues such as Parkinson's Disease, Multiple Sclerosis and Stroke. The apparatus includes a multi-configurable seat which is horizontally displaced from the foot pedal and handlebar assemblies. A vaned wheel rotatably mounted on the frame and arranged to absorb energy by movement of the broad surfaces of the vanes against the surrounding body of air. A derailleur mechanism is provided for additional options of resistance intensity. Rotation of the wheel is effected through a pair of foot pedals and connected chain and sprocket/hub mechanism and/or through a pair of handlebar assemblies. The handlebar assemblies each include a pivotal spring housing mechanism which enables the handlebars to be both retractable and variable in their positioning to the user. Each handlebar assembly is pivotally connected to the frame and is also connected to a respective eccentric through a crank ring rotatably mounted on that eccentric and a drive bar connected to both the crank ring and the handlebar stem. The two eccentrics are arranged 180 degrees out of phase and are connected to the foot pedals so as to rotate in response to both the pivotal movement of the handlebar stems and the circular movement of the foot pedals. As the eccentrics are drivably connected to the vaned wheel, that vaned wheel is caused to rotate in response to rotation of the eccentrics.
Owner:ALLEN TAD

Selective Caspase Inhibitors and Uses Thereof

The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and / or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).
Owner:GENESIS TECH LTD

Diagnostic miRNA profiles in multiple sclerosis

The invention relates to methods for diagnosing mulötiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.
Owner:SIEMENS HEALTHCARE GMBH

Application of hepatocyte growth factor in preparation of medicines for treating multiple sclerosis

The invention discloses an application of a hepatocyte growth factor (HGF) and a medulla desmohemoblast stem cell (MSC)-containing conditioned medium (MSC-CM) in preparation of medicines for treating multiple sclerosis (MS). The research result shows that in a cord sheath oligodendrocyte glycoprotein 35-55 peptide fragments (MOG35-55) induced MS animal model EAE, human MSC paracrine substance-containing MSC-CM is provided to reduce the EAE functional defect, and the growth of oligodendrocyte and neuron can be promoted when the functional cells are injured, wherein the HGF which is released by MSC performs the main effect; the effect provided to HGF is similar with MSC-CM, and the growth and movement of oligodendrocyte and neuron can be stimulated, the cord sheath restoration capability can be enhanced, the pathology load of MS animal model (EAE) can be minimized, the disease recovery function can be promoted, and short HGF treatment on the EAE model is provided for continuously guiding the disease function improvement. According to the invention, the application scope of HGF and MSC-CM can be widened, an effective medicine is provided for clinical treatment of MS, and the deep exploitation of a novel high efficiency MS treatment medicine can be realized simultaneously.
Owner:THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA

N-hydroxyl-5-substituted-1H-pyrazol-3-formamide compound as well as preparation method and use thereof

The invention belongs to the field of medicine chemistry, and particularly relates to an N-hydroxyl-5-substituted-1H-pyrazol-3-formamide compound as well as a preparation method and use thereof. The specific structure of the compound is as shown in a formula I. The invention also provides a synthesis method of the compound in the formula I and inhibition activity thereof for acidic sphingomyelinase. The compound can be used for developing drugs for treating atherosclerosis (AS), diabetes, emphysema, pulmonary edema, pulmonary fibrosis, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary arterial hypertension, non-alcoholic fatty liver disease, Alzheimers (AD), multiple sclerosis (MS), cerebral stroke and depression diseases. (the formula I is shown in the description).
Owner:CHINA PHARM UNIV
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