Diagnostic miRNA profiles in multiple sclerosis

A multiple sclerosis, hsa-mir-20a-5p technology, applied in the direction of microbial measurement/testing, biochemical equipment and methods, etc., can solve expensive, unpleasant, time-consuming and other problems

Active Publication Date: 2015-03-18
SIEMENS HEALTHCARE GMBH
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Problems solved by technology

Obtaining clinical, imaging, experimental and radiological data on the dissemination of MS lesions is required for diagnosis, which can be time-consuming, expensive and difficult
Testing of cerebrospinal fluid (CSF) can be performed to help diagnose MS, however, obtaining CSF involves the unpleasant and risky step of lumbar puncture

Method used

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  • Diagnostic miRNA profiles in multiple sclerosis
  • Diagnostic miRNA profiles in multiple sclerosis
  • Diagnostic miRNA profiles in multiple sclerosis

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Embodiment Construction

[0068] Additional details, characteristics, characteristics and advantages of the object of the present invention are further disclosed in the following description and in the accompanying drawings of various examples illustrating by way of example preferred embodiments of the invention. However, these examples should not be construed as limiting the scope of the present invention in any way.

[0069] The present invention relates to a method for diagnosing multiple sclerosis using miRNA markers.

[0070] The diagnosis of multiple sclerosis is challenging in patients with an atypical presentation and during first nerve deficits that may involve inflammatory demyelination. In particular, CIS / RRMS is difficult to diagnose and often presents in the early stages of the disease. However, it would be particularly desirable to have a reliable diagnostic test for this disease stage, since the timing of therapeutic intervention is better during this early disease stage. Diagnosing RR...

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Abstract

The invention relates to methods for diagnosing mulötiple sclerosis with miRNA markers. Diagnosis of multiple sclerosis (MS) can be challenging in patients with atypical presentations and during a first neurological deficit possibly related to inflammatory demyelination. Towards the identification of biomarkers for diagnosis of MS, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified, which have previously not been related to MS according to the microRNA disease database. These miRNAs could potentially serve as future diagnostic biomarkers for MS and help in diagnosis, monitoring disease activity, and evaluation of treatment responses in patients with MS.

Description

technical field [0001] The present invention relates to a method for diagnosing multiple sclerosis. Background technique [0002] Recently, molecular diagnostics have received increasing attention. Molecular diagnostics has found an entry point into the clinical diagnosis of diseases (especially detection of infectious pathogens, detection of genomic mutations, detection of diseased cells and identification of risk factors for disease triggers). [0003] In particular, nucleic acid analysis opens up new and very promising possibilities in the study and diagnosis of diseases by determining gene expression in tissues. [0004] The target nucleic acid to be detected includes genomic DNA, expressed mRNA and other RNA such as microRNA (MiRNA) (abbreviated as miRNA). miRNA is a new class of small RNA with various biological functions (A. Keller et al., Nat Methods. 20118(10):841-3). They are short (average 20-24 nucleotides) ribonucleic acid (RNA) molecules found in eukaryotic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q2600/178C12Q2600/158C12Q1/6883C12Q2600/118
Inventor A.凯勒E.米斯C.F.斯特勒A.卡普尔P.莱丁格C.巴克斯
Owner SIEMENS HEALTHCARE GMBH
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