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33results about How to "Has an immunosuppressive effect" patented technology
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Medical usage of periplocin A and E
InactiveCN1939324AHas an immunosuppressive effectOrganic active ingredientsMetabolism disorderImmunosuppressive effectBiomedical engineering
A medical application of periplocoside A and E in preparing the immunodepress ant with high effect and low poison is disclosed.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Method for separating, extracting and purifying nonyl alcohol from plant and its application
InactiveCN1380277AAntibacterialAnti-inflammatoryHydroxy compound separation/purificationAlcoholMedicine
The present invention relates to a method for separating, extracting and purifying compound add nonanol from medicinal plant siegesbeckia and the application of said compound in preparation of medicine. The medicine preparation made up by using add nonanol as leading compound possesses the effect of resisting rheumatoid arthritis, stopping pain, resisting bacteria, antimalarial, reducing blood pressure and relaxing blood vessel, etc. and possesses the advantages of low toxicity and obvious medicine effect.
Owner:林文翰
Alkannin derivatives as immune inhibitors and metal complexes thereof
InactiveCN1546450AHas an immunosuppressive effectCopper organic compoundsCalcium organic compoundsMS multiple sclerosisHydrogen
An alkannin derivative as immuno-suppressive agent and its metallic complex compound with a chemical constitution formulas III and IV disclosed in the specification, wherein in formula III, R is C1-6 saturated, unsaturated and aromatic acyl, in formula IV, R is hydrogen, C1-6 saturated, unsaturated and aromatic acyl, M is metallic Cu, Ca, Zn. The present invention realizes immunological suppression effect, thus can be used for treating diseases relating to human body autoimmune including chronic infectious arthritis, scleredema, lupus erythematosus, HIV infection and malignant tumor.
Owner:SHANGHAI JIAO TONG UNIV
Mesenchymal stem cell membrane-coated bionic nanoparticles with overexpressed PD-L1 molecules on surface as well as preparation and application of mesenchymal stem cell membrane-coated bionic nanoparticles
ActiveCN111265549AThe preparation process is simple and matureHigh biosecurityAntibacterial agentsAntimycoticsCell membraneImmunity response
The invention relates to mesenchymal stem cell membrane-coated bionic nanoparticles with overexpressed PD-L1 molecules on the surface as well as preparation and application of the mesenchymal stem cell membrane-coated bionic nanoparticles. The mesenchymal stem cell membrane-coated bionic nanoparticle with the overexpressed PD-L1 molecules on the surface comprises a nano-core and a mesenchymal stemcell membrane wrapping the nano-core, the nano core comprises a polymer with biocompatibility, and PD-L1 molecules are overexpressed on the membrane surface of the mesenchymal stem cell membrane. Theinvention also discloses an application of the mesenchymal stem cell membrane-coated bionic nano-particle with over-expressed PD-L1 molecules on the surface in preparation of an inflammation treatment preparation. The bionic nanoparticle has a remarkable immunosuppression effect, is high in biocompatibility and simple and mature in preparation process, can be used for preparing an inflammation treatment preparation, can be effectively enriched in an inflammation part, and shows an excellent curative effect in inflammation treatment by inhibiting excessively activated immune response and cytokine storm of the inflammation part.
Owner:SUZHOU UNIV
Preparation method of novel medical cell repairing agent
ActiveCN108685948AEasy to prepareHas an immunosuppressive effectCell dissociation methodsPeptide/protein ingredientsMesenchymal stem cellBiology
The invention relates to medicine for restoring wound, in particular to a preparation method of a novel medical cell repairing agent. The preparation method has the concrete preparation steps of separation purification and culture of human amniotic mesenchymal stem cells, preparation of a sodium alginate complexing agent and preparation of a cell restoring agent. The invention builds the preparation method of human amniotic mesenchymal stem cells and a corresponding stem cell bank, and makes the preparation for large-scale production and preparation of the human amniotic mesenchymal stem cellrepairing agent and the application of the repairing agent.
Owner:北京壹典壹生生物技术有限公司
Chinese medicinal composition for treating prostatitis or prostate hyperplasia and preparation method
ActiveCN101647843AGasification function is normalSignificant effectPill deliveryUrinary disorderTraditional medicineProstate hyperplasia
The invention belongs to the field of Chinese medicament, and provides a Chinese medicinal composition for treating prostatitis or prostate hyperplasia and a preparation method for the Chinese medicinal composition. The Chinese medicinal composition is prepared from the following raw materials in portion by weight: 1 to 5 portions of rape pollen and 1 to 5 portions of wild chrysanthemum, wherein the optimal dose is based on the weight ratio of the rape pollen to the wild chrysanthemum of 1 to 1. The Chinese medicinal composition has quite remarkable effect of treating the prostatitis and the prostate hyperplasia. The preparation method can effectively extract effective components of the medicament, remove impurities and well exert medicinal effect.
Owner:JIANGSU KANION PHARMA CO LTD
Chinese medicine for treating systemic lupus erythematosus and preparation thereof
ActiveCN101301392AGood curative effectReduce the incidence of infectious complicationsAnthropod material medical ingredientsSkeletal disorderHormoneOldenlandia diffusa
The invention relates to a Chinese medicine for treating the systemic lupus erythematosus, particularly the lupus nephritis and a method for preparing the same. The medicine consists of the following components of oldenlandia diffusa, barbat skullcap, redroot gromwell, glutinous rehmannia, root of red-rooted salvia, motherwort and scorpion. The medicine has effects of clearing away the heat-evil and expelling superficial evils and activating blood circulation to dissipate blood stasis and is mainly used to treat the systemic lupus erythematosus, particularly the lupus nephritis; moreover, by matching Western medicines such as glucocorticoid and immunodepressant, etc., the medicine can be used to jointly treat the systemic lupus erythematosus, which can improve the effect of the hormone and the immunodepressant in curing the systemic lupus erythematosus, lower the incidence rate of infecting the complication, lower the recurernce rate and the death rate and have the important clinical meaning. The medicine of the invention can be made in all medicament forms for clinical use, including the powder, the medicinal broth, the mixture, the oral taking liquid, the capsule, the pelletized granule and the concentrated pill, etc.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Mesenchymal stem cells and exosomes of mesenchymal stem cells and application of mesenchymal stem cells in treating anal fistula
PendingCN110607274AHas an immunosuppressive effectEasy to synthesizePeptide/protein ingredientsDigestive systemBlood plasmaPlasma rich platelet
The invention discloses mesenchymal stem cells and exosomes of the mesenchymal stem cell and application of the mesenchymal stem cells in treating anal fistula, and further discloses a method for treating anal fistula by using an autologous-fat-derived mesenchymal stem cell mixed preparation. The stem cell preparation includes autologous-adipose-derived mesenchymal stem cells (ADSCs) and exosomes(EXO-ADSCs) of the ADSCs, autologous platelet-rich plasma (PRP) and synthetic bacteriostatic peptides (AMP). The stem cells have immunoregulatory functions, the exosomes create a micro-environment which is conducive to recovery, meanwhile, the stem cells are stimulated to release various growth factors, and wound healing is promoted. PROP gel provides support and nutrients and works synergistically with stem cells, the survival rate after stem cell transplantation is improved, and the stem cells can better play a role. The synthetic peptides are single in components and controllable and reducethe incidence of infection. The combined use greatly improves the cure rate of anal fistula.
Owner:沈阳细胞治疗工程技术研发中心有限公司
New immunosuppressive agent extracted from Honghuoma and extraction method and use thereof
ActiveCN101585823AHas an immunosuppressive effectReduced induction of immature DCOrganic chemistryAntipyreticDiseaseDendritic cell
The invention obtains neodicoumarin compound that is 1,3-(6',6'',7',7''-tetramethoxy-8', 8''-dicoumarin)-acetone with immunologic suppression effect, in particular with induced specific immunologic tolerance effect that is extracted and separated from Honghuoma acetic ether extract, wherein the compound produces induced specific immunologic tolerance or achieve new balance effect for unbalanced immune system by inhibiting the multiplication of T lymphocyte, reducing the expression of intracellular transcription factor T-bet of dendritic cell (DC), inducing immature DC and adding the amount of T cells expressing Foxp3 regulation and can be used as an immunosuppressive agent, thereby being used for the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Owner:HUAZHONG UNIV OF SCI & TECH +1
Application of IL-21 to prepare immunosuppressor
InactiveCN103566357APromote secretionInduced secretionPeptide/protein ingredientsBlood/immune system cellsDiseaseImmunosuppressive drug
The invention relates to the field of immunosuppressive drugs, in particular to application of IL-21 to prepare an immunosuppressor and a method for promoting a regulatory B cell (B10) to differentiate and IL-10 to secrete by IL-21. Related experimental results show that: IL-21 is mainly used for promoting IL-10 to secrete by inducing phosphorylation-STAT3 to activate; IL-10 generated by induction can inhibit proliferation of in-vitro T cells and has the immunosuppressive action; and IL-21 can be used as the cell factor of in-vitro amplification cells and can be further used for preparing drugs for treating autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, scleroderma and the like.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
Composition and method conducive to acquiring follicular regulatory T cells in vitro and application of composition
ActiveCN107177547APromote differentiationPromote secretionCulture processBlood/immune system cellsIrritationAutoimmune disease
The invention relates to a composition and a method conducive to acquiring follicular regulatory T cells in vitro and an application of the composition. The invention proves that differentiation and number proliferation of in-vitro Tfr (follicular regulatory T cells) can be effectively induced by the aid of irritation of TGF (transforming growth factor)-beta, IL (interleukin)-2, anti-CD3 antibodies, anti-CD28 antibodies and baicalin, and expression of Foxp3 in the Tfr is facilitated. The Tfr cells amplified by the method can be used for treating autoimmune diseases and chronic inflammatory diseases, the autoimmune diseases include lupus erythematosus, dermatomyositis, vasculitides, sicca syndrome, scleroderma, rheumatoid arthritis, ankylosing spondylitis, disseminated sclerosis and autoimmune hepatitis, and the chronic inflammatory diseases include diabetes, coronary heart diseases, hyperlipemia, eczema, vitiligos, atopic dermatitis, lichen planus and the like.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV
Formula feed for treating gosling plague and preparation method of formula feed
InactiveCN106798149AImprove immunityHigh cure rateAnthropod material medical ingredientsFood processingGARLIC POWDERRapeseed
The invention discloses a formula feed for treating gosling plague and a preparation method of the formula feed. The feed comprises the raw materials of corns, wheat, millet, glutinous rice, wheat bran, rapeseed meal, mung bean flour, lotus root starch, carrot, yam flour, bombyx batryticatus powder, corn oil, salt, vitamin premix, microelement premix, yeast powder, alfalfa meal, garlic powder, calcium hydrophosphate, limestone powder, triethylhexanoin and ammonium ferric citrate. The preparation method comprises the steps of preparing, crushing, burdening and granulating a traditional Chinese medicine additive. The formula feed has the beneficial effects that the formula feed is relatively short in treatment course, relatively good in curative effect, free of medicine residue and low in cost price; the traditional Chinese medicine additive is matched with other feed raw materials and interacts with the other feed raw materials, so that the gosling plague can be treated, the nutrient requirements of goslings can be met, the formula feed is especially suitable for the nutrient requirements of the goslings with the gosling plague, and a certain healthcare function on the organism can be achieved after a consumer eats the goose meat.
Owner:新昌县拜瑞珂生物技术有限公司
Compound mouthwash
PendingCN113521253AReduce incidenceReduce infection rateOrganic active ingredientsPeptide/protein ingredientsDexamethasoneOral mucous membrane
The invention discloses compound mouthwash. The compound mouthwash is prepared by adding 10mg of dexamethasone sodium phosphate injection, 113mg of recombinant human interleukin for injection and 0.4 g of lidocaine injection into 200ml of sterilizing water for injection, and uniformly mixing the materials. The compound mouthwash can reduce the incidence rate and infection rate of chemoradiotherapy-related oral mucositis and shorten the hospitalization time.
Owner:中国人民解放军西部战区总医院
Traditional Chinese medicine composition for relieving postoperative pain and accelerating wound healing
InactiveCN110025689AHeat-clearing and detoxifyingWith swelling and pain reliefHeavy metal active ingredientsAntipyreticTreatment effectSaposhnikovia
The invention provides a traditional Chinese medicine composition for relieving postoperative pain and accelerating wound healing, and relates to the technical field of traditional Chinese medicines.The traditional Chinese medicine composition comprises the following raw materials in parts by mass of 25-40 parts of ceratostigma willmottianum roots, 15-30 parts of scandent schefflera roots, 12-23parts of rhizoma bolbostemmae, 20-40 parts of halloysitum rubrum, 15-30 parts of ligusticum wallichii, 10-20 parts of caulis sinomenii, 3-9 parts of long peppers, 5-10 parts of radix sophorae flavescentis, 4-11 parts of camphortree leaves, 10-16 parts of divaricate saposhnikovia roots, 7-18 parts of swordlike atractylodes rhizomes, 4-10 parts of field thistle herbs, 5-20 parts of cyrtomium balansae rhizomes, 13-27 parts of slender dutchmanspipe roots, 20-30 parts of licorice roots and 6-15 parts of fructus aurantii. The traditional Chinese medicine composition can notably relieve postoperativepain and accelerate wound healing, is notable in treatment effects, is reasonable in formula of raw materials, is simple to prepare, and can be further prompted and applied.
Owner:毕凌波
New use of hemin and compound thereof to medicines
PendingCN110585215AEnhance anti-inflammatoryHas an immunosuppressive effectOrganic active ingredientsAntipyreticDrugSpleen Tissue
The invention provides an application of hemin and / or hemin compounds thereof to preparation of medicines for preventing and treating rheumatoid arthritis. The hemin or the hemin compounds have remarkable effect of resisting inflammation when being used for performing in vitro action on macrophages, can effectively restrain vola swelling for a rat arthritis model, and can notably reduce expressionof metapodium inflammatory factor mRNA and mRNA expression of liver and spleen tissue autoimmunity correlation factors. The application explains that the hemin or the hemin compounds have good effectof preventing and treating rheumatoid arthritis.
Owner:SUN YAT SEN UNIV
Preparing method of compound FK506-A
ActiveCN102924478BHigh purityHas an immunosuppressive effectOrganic chemistryOrganic solventBiochemical engineering
The invention provides a preparing method of a compound FK506-A, which includes the following steps: a) heating FK506 for 2 to 25 minutes under 110 to 150 degrees C, so as to obtain a FK506-A crude product; b) adding organic solvent into the FK506-A crude product, adding silica gel after dissolving, and drying after uniformly stirring, so as to obtain a dry sample; and c) adding the dry sample into a chromatographic column filled with silica gel and eluting by adding eluting solvent, and collecting the eluent with the FK506-A purity determined by HPLC to be no less than 75% and concentrating to be dry solid, so as to obtain FK506-A pure product by crystallizing the solid. The preparing method of compound FK506-A has the advantages that the operation is simple, and the industrial production is easy.
Owner:NCPC NEW DRUG RES & DEV
Faded shewanella oneidensis LCT-SM262 strain in space environment
InactiveCN103173374BHigh activityImmunosuppressedBacteriaMicroorganism based processesMetaboliteProtein molecules
The invention relates to a faded shewanella oneidensis LCT-SM262 strain in a space environment, and biological characteristics, a genomic deoxyribonucleic acid (DNA) sequence, a transcriptome and differential proteomics of the faded shewanella oneidensis LCT-SM262 strain, and in particular relates to a functional sequence and a molecule which are analyzed and identified through comparing with ground faded shewanella oneidensis. The mutant gene, differential expression gene and protein molecule of the faded shewanella oneidensis in the space environment can be comprehensively and accurately obtained, so that researches on the function and mechanism of the space environment on microorganisms are facilitated, and the safety of the space environment is guaranteed; novel toxicity and drug-resistant target spots can be conveniently found out, so that novel treatment target spots are provided for clinic infectious diseases; and a metabolic product-prodigiosin of the strain has functions of tumor resisting and immunosuppression and has a potential application prospect.
Owner:GENERAL HOSPITAL OF PLA
Application of peritoneal cells to induction of differentiation of T cells into regulatory T cells
ActiveCN110184237APromote productionHas an immunosuppressive effectBlood/immune system cellsRegulatory T cellImmunosuppressive effect
The invention relates to an application of peritoneal cells to induction of differentiation of T cells into regulatory T cells, belongs to the field of medicines, aims to solve the problems that obtaining enough regulatory T cells from tissue for treatment is difficult, and few obtaining methods exist, and provides an application of peritoneal cells to induction of differentiation of T cells intoregulatory T cells. The method comprises the following steps of firstly, detecting the expression situation of various markers on surfaces of the peritoneal cells, confirming whether the peritoneal cells are a mixture of various suppressor cells of B cells, macrophages, the T cells and the like, and confirming that the peritoneal cells have immunosuppressive action; and then performing co-cultureon the peritoneal cells and the T cells, wherein the results confirm that CD3+CD4+CD25+Foxp3+ regulatory T cells are obviously increased, and the peritoneal cells can induce the differentiation of T cells into regulatory T cells, and can promote generation of the regulatory T cells. The invention provides a new method for preparing the regulatory T cells.
Owner:THE WEST CHINA SECOND UNIV HOSPITAL OF SICHUAN
Porcine reproductive and respiratory syndrome, porcine pseudorabies dual live vaccine and its preparation method and application
ActiveCN107537034BAvoid mutual interferenceHas an immunosuppressive effectViral antigen ingredientsAntiviralsRabiesPig breeding
The invention provides a vaccine composition, which comprises live porcine reproductive and respiratory syndrome virus antigen and immune dose live virus antigen of porcine pseudorabies virus, and a freeze-drying protective agent. The vaccine composition provided by the invention has good immunogenicity and safety, and the vaccine composition solves the immunosuppressive problem of porcine reproductive and respiratory syndrome antigen and porcine pseudorabies antigen under the condition that the antigen content is relatively low , has a significant immune protection effect on the prevention of porcine reproductive and respiratory syndrome and porcine pseudorabies.
Owner:PU LIKE BIO ENG
A method for in vitro expansion of umbilical cord blood Treg cells
ActiveCN107164324BHigh purityIncrease multipleBlood/immune system cellsCell culture active agentsCord blood stem cellBlood plasma
The invention relates to an in-vitro amplification method of cord blood Treg cells, comprising the steps of S1, isolating mononuclear cells; S2, adjusting cellular density, inoculating to a culture flask, and adding inactivated plasma; on the first day, adding coumestrol, TGF-beta, CD3 / CD28 monoclonal antibody and IL-2; S3, on the fourth day, supplementing a culture medium, adding inactivated plasma, coumestrol and TGF-beta, and keeping the final concentration constant; S4, on the sixth day, supplementing the culture medium, and keeping the final concentrations of other components unchanged; S5, on the ninth day, supplementing the culture medium, and keeping the final concentrations of other components unchanged; S6, on the twelfth day, collecting cells. The amplification of CD4, CD25 and Tregs is induced under the coaction of coumestrol and TGF-beta, the amplifying efficiency is high, and high-purity Treg cells can be acquired without pre-purification.
Owner:深圳市沃英达生命科学有限公司
Faded shewanella oneidensis LCT-SM262 strain in space environment
InactiveCN103173374AHigh activityImmunosuppressedBacteriaMicroorganism based processesMetaboliteProtein molecules
The invention relates to a faded shewanella oneidensis LCT-SM262 strain in a space environment, and biological characteristics, a genomic deoxyribonucleic acid (DNA) sequence, a transcriptome and differential proteomics of the faded shewanella oneidensis LCT-SM262 strain, and in particular relates to a functional sequence and a molecule which are analyzed and identified through comparing with ground faded shewanella oneidensis. The mutant gene, differential expression gene and protein molecule of the faded shewanella oneidensis in the space environment can be comprehensively and accurately obtained, so that researches on the function and mechanism of the space environment on microorganisms are facilitated, and the safety of the space environment is guaranteed; novel toxicity and drug-resistant target spots can be conveniently found out, so that novel treatment target spots are provided for clinic infectious diseases; and a metabolic product-prodigiosin of the strain has functions of tumor resisting and immunosuppression and has a potential application prospect.
Owner:GENERAL HOSPITAL OF PLA
A kind of preparation method of medical cell repairing agent
ActiveCN108685948BEasy to prepareHas an immunosuppressive effectCell dissociation methodsPeptide/protein ingredientsMesenchymal stem cellBiochemistry
The invention relates to medicine for restoring wound, in particular to a preparation method of a novel medical cell repairing agent. The preparation method has the concrete preparation steps of separation purification and culture of human amniotic mesenchymal stem cells, preparation of a sodium alginate complexing agent and preparation of a cell restoring agent. The invention builds the preparation method of human amniotic mesenchymal stem cells and a corresponding stem cell bank, and makes the preparation for large-scale production and preparation of the human amniotic mesenchymal stem cellrepairing agent and the application of the repairing agent.
Owner:北京壹典壹生生物技术有限公司
Pyrrole sesquiterpene compound, preparation method and uses thereof
ActiveCN110357864ANovel structureHas an immunosuppressive effectOrganic chemistryMicroorganism based processesPyrroleImmunosuppressive effect
The invention provides a pyrrole sesquiterpene compound, a preparation method and uses thereof, and belongs to the field of medicine. According to the present invention, the pyrrole sesquiterpene compound has novel structure, has immunosuppressive action, can be used for preparing immunosuppressive agents, has broad application prospects, and has a structural general formula defined in the specification.
Owner:KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
Alkannin derivatives as immune inhibitors and metal complexes thereof
InactiveCN1271032CHas an immunosuppressive effectCopper organic compoundsCalcium organic compoundsMS multiple sclerosisHydrogen
An alkannin derivative as immuno-suppressive agent and its metallic complex compound with a chemical constitution formulas III and IV disclosed in the specification, wherein in formula III, R is C1-6 saturated, unsaturated and aromatic acyl, in formula IV, R is hydrogen, C1-6 saturated, unsaturated and aromatic acyl, M is metallic Cu, Ca, Zn. The present invention realizes immunological suppression effect, thus can be used for treating diseases relating to human body autoimmune including chronic infectious arthritis, scleredema, lupus erythematosus, HIV infection and malignant tumor.
Owner:SHANGHAI JIAOTONG UNIV
Chinese medicinal composition for treating prostatitis or prostate hyperplasia and preparation method
ActiveCN101647843BGasification function is normalSignificant effectPill deliveryUrinary disorderTraditional medicineProstate hyperplasia
The invention belongs to the field of Chinese medicament, and provides a Chinese medicinal composition for treating prostatitis or prostate hyperplasia and a preparation method for the Chinese medicinal composition. The Chinese medicinal composition is prepared from the following raw materials in portion by weight: 1 to 5 portions of rape pollen and 1 to 5 portions of wild chrysanthemum, wherein the optimal dose is based on the weight ratio of the rape pollen to the wild chrysanthemum of 1 to 1. The Chinese medicinal composition has quite remarkable effect of treating the prostatitis and the prostate hyperplasia. The preparation method can effectively extract effective components of the medicament, remove impurities and well exert medicinal effect.
Owner:JIANGSU KANION PHARMA CO LTD
A kind of pharmaceutical composition, its preparation method and application
ActiveCN106176836BHas an immunosuppressive effectLow toxicityImmunological disordersConiferophyta medical ingredientsDrug compoundImmunosuppressive effect
The invention relates to a drug and specifically relates to a drug compound. The drug compound contains taxus mairei extracts and a pharmaceutically acceptable carrier, wherein the weight percent of the taxus mairei extracts is 0.1-99.9%. The resources of the drug compound are natural; the preparation technique is simple; the toxicity to cells is low; the immunosuppressive action is higher; the application prospect is wide.
Owner:无锡紫杉药业股份有限公司
Medical usage of periplocin A and E
InactiveCN1939324BHas an immunosuppressive effectOrganic active ingredientsMetabolism disorderImmunosuppressive effectBiomedical engineering
A medical application of periplocoside A and E in preparing the immunodepress ant with high effect and low poison is disclosed.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
New immunosuppressive agent extracted from Honghuoma and extraction method and use thereof
ActiveCN101585823BHas an immunosuppressive effectIncrease the number ofOrganic chemistryAntipyreticDendritic cellAutoimmune condition
The invention obtains neodicoumarin compound that is 1,3-(6',6'',7',7''-tetramethoxy-8', 8''-dicoumarin)-acetone with immunologic suppression effect, in particular with induced specific immunologic tolerance effect that is extracted and separated from Honghuoma acetic ether extract, wherein the compound produces induced specific immunologic tolerance or achieve new balance effect for unbalanced immune system by inhibiting the multiplication of T lymphocyte, reducing the expression of intracellular transcription factor T-bet of dendritic cell (DC), inducing immature DC and adding the amount ofT cells expressing Foxp3 regulation and can be used as an immunosuppressive agent, thereby being used for the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
Owner:HUAZHONG UNIV OF SCI & TECH +1
Membrane-coated biomimetic nanoparticles of mesenchymal stem cells with overexpressed PD-L1 molecules on the surface and their preparation and application
ActiveCN111265549BThe preparation process is simple and matureHigh biosecurityAntibacterial agentsAntimycoticsCell membraneImmunity response
The invention relates to a biomimetic nanoparticle coated with a mesenchymal stem cell membrane with PD-L1 molecules overexpressed on the surface, and its preparation and application. The mesenchymal stem cell membrane-coated biomimetic nanoparticle with PD-L1 molecule overexpression on the surface of the present invention includes a nano-core and a mesenchymal stem cell membrane wrapped outside the nano-core; the nano-core includes a biocompatible polymer, The membrane surface of mesenchymal stem cell membranes overexpresses PD‑L1 molecules. The present invention also discloses the application of the membrane-coated biomimetic nanoparticles of mesenchymal stem cells overexpressed on the surface of PD-L1 molecules in the preparation of inflammation treatment preparations. The biomimetic nanoparticle of the present invention has significant immunosuppressive effect, good biocompatibility, simple and mature preparation process, and can be used to prepare inflammation treatment preparations, which can be effectively enriched in the inflammatory site, by inhibiting the excessively activated immune response of the inflammatory site and cytokine storm, showing excellent curative effect in the treatment of inflammation.
Owner:SUZHOU UNIV
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