33 results about "Coumestrol" patented technology

The present invention relates to a skin cosmetic product containing 3,9-diferulylcoumestrol, especially to a skin cosmetic product containing a compound in which ferulylic acid is bonded to a coumestrol. The skin cosmetic product has several excellent effects for improving cosmetic disorders, such as anti-aging effect, whitening effect and hair-seeding effect.

The present invention provides new coumestans compounds and processes for the preparation of coumestans, pharmaceutical compositions having a coumestan as an active pharmaceutical ingredient, and methods of utilizing coumestans as selective estrogen receptor modulators (SERMs) for treating estrogen dependent diseases such as breast cancer.

The present invention relates to a composition for activating mitochondria, comprising, as an active ingredient, coumestrol, or a bean extract containing coumestrol.

The invention discloses a synthetic method of a polyhydroxy substituted coumestrol natural product. 2-bromine-4-hydroxyphenylacetic acid serves as a raw material to make a condensation reaction with a hydroxy substituted salicylaldehyde compound, and a hydroxy substituted 3-(2-bromine-4-hydroxycyclohexyl phenyl)-7-hydroxy coumarin compound is obtained; and then a hydroxylation / oxidative coupling reaction is made under the condition of a catalyst and microwave heating, and the polyhydroxy substituted coumestrol natural product is obtained. The synthetic method is simple in route, easy and convenient to operate, high in yield, soft in reaction condition, free of needs of precious metal catalyzing, high in atom economy and low in cost, and multiple steps of cascade reactions are made simultaneously.

The present invention relates to a method for increasing the coumestrol content of germinated fermented beans by irradiating visible light with a light-emitting diode after germinating and fermenting beans, and germinated fermented beans produced by the method.

The present specification relates to a culturing method for cultured leguminous roots having an increased coumestrol content, the method being capable of mass-producing coumestrol, which is present ina very small amount in a leguminous plant, wherein the culturing method comprises the steps of: (a) germinating leguminous seeds in a culture medium to induce in vitro plants having cotyledons, hypocotyls, and radicles; (b) culturing, in a culture medium, at least one site of the cotyledons, hypocotyls, and radicles of the induced in vitro plant to induce site-specific cultured roots; and (c) multiplying the induced site-specific cultured roots in a culture medium, wherein the culture media contain nutrient components of NH4NO3, CaCl2.2H2O, MgSO4.7H2O, KH2PO4, and KNO3.

The invention relates to an in-vitro amplification method of cord blood Treg cells, comprising the steps of S1, isolating mononuclear cells; S2, adjusting cellular density, inoculating to a culture flask, and adding inactivated plasma; on the first day, adding coumestrol, TGF-beta, CD3 / CD28 monoclonal antibody and IL-2; S3, on the fourth day, supplementing a culture medium, adding inactivated plasma, coumestrol and TGF-beta, and keeping the final concentration constant; S4, on the sixth day, supplementing the culture medium, and keeping the final concentrations of other components unchanged; S5, on the ninth day, supplementing the culture medium, and keeping the final concentrations of other components unchanged; S6, on the twelfth day, collecting cells. The amplification of CD4, CD25 and Tregs is induced under the coaction of coumestrol and TGF-beta, the amplifying efficiency is high, and high-purity Treg cells can be acquired without pre-purification.

The present invention relates to a germinated and fermented bean extract containing coumestrol, a preparation method thereof, and a composition comprising the germinated and fermented bean extract. For liver toxicity, the germinated and fermented bean extract of the present invention effectively protects the liver through the in vitro (in vitro) antioxidant activity and cell survival rate and blood tests of animal models, measurement of MDA, GST, GSH, SOD, CAT, etc. cell. In addition, it significantly increases bone density by increasing bone mineral content and has the effect of increasing the thickness and amount of cancellous bone. In addition, it also has the effect of relieving menopausal symptoms.

The invention discloses a nonsense mutation read-through function of coumestrol. The primary experiment result shows that expression of luciferase containing nonsense mutation can be partially recovered by the coumestrol in a cell model, in the extracellular protein truncation experiment, expression of an ATM gene containing nonsense mutation can be partially recovered by the cumestrol, and the coumestrol is expected to serve as a lead compound for developing new medicine through structural transformation and modification to treat various diseases caused by nonsense mutation, and the coumestrol has potential medicinal application.

The present invention provides gero-protective pharmaceutical compositions and methods, the compositions being adapted to enhance at least one of cell survival and cell metabolism in a mammalian subject, the pharmaceutical compositions include at least two of Withaferin a or its structural analogs, coumestrol, ginsenoside, quinidine, silymarin, licochalcone a, lipoic acid and apigenin, in a pharmaceutically effective amount.

The present invention relates to a composition for, inter alia, preventing or treating a climacteric disease, or preventing or improving a climacteric skin symptom comprising a soybean extract comprising coumestrol as an active ingredient, and more specifically relates to a composition for, inter alia, preventing or treating a climacteric disease, or preventing or improving a climacteric skin symptom comprising a germinated and fermented soybean extract comprising coumestrol as an active ingredient.