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Coumestrol-containing germinated fermented soybean extract having hepatocyte protective effect and bone density increase effect and composition containing same

A technology to increase bone density and coumestrol, applied to medical preparations containing active ingredients, active ingredients of heterocyclic compounds, drug delivery, etc., can solve the problems of use method, dosage, safety and no results, and achieve relief Effects of menopausal symptoms, protection of liver cells, increase in thickness and number

Active Publication Date: 2018-08-21
HUBIO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hormone replacement therapy (estrogen replacement therapy, estrogen replacement therapy) has been proposed as a preventive measure, but there are no results regarding the method of use, dosage, safety, etc.

Method used

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  • Coumestrol-containing germinated fermented soybean extract having hepatocyte protective effect and bone density increase effect and composition containing same
  • Coumestrol-containing germinated fermented soybean extract having hepatocyte protective effect and bone density increase effect and composition containing same
  • Coumestrol-containing germinated fermented soybean extract having hepatocyte protective effect and bone density increase effect and composition containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] [Example 1] Materials and methods

[0052] 1.1. Experimental materials

[0053] The germinated fermented beans used in this experiment were obtained from Hubio Co., Ltd. Soybeans obtained from Jeju Agricultural Research and Extension Services were germinated according to previous research and inoculated with Aspergillus oryzae for fermentation. After water washing, beneficiation and extraction using ultrasonic waves, it is dried and used as a test sample.

[0054] 1.2. Sample preparation

[0055] Soybeans are washed, selected, germinated, fermented with Aspergillus oryzae, filtered and then dried at 60°C. To 10 g of the dry sample, 80% ethanol was added at 7 mL / g to decompose it, and then hot water extraction was performed using ultrasonic waves. Thereafter, the germinated fermented bean extract was obtained by centrifugation, filtered through a polytetrafluoroethylene membrane (PTFE membrane), and then dried to obtain a sample. The above samples were dissolved in ...

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Abstract

The present invention relates to a germinated fermented soybean extract containing coumestrol, a preparation method therefor, and a composition containing the germinated fermented soybean extract. Itcan be seen that the germinated fermented soybean extract of the present invention is effective in the hepatocyte protection against hepatotoxicity through in vitro antioxidative activity and cell viability, and hematological tests and MDA, GST, GSH, SOD, and CAT measurements in animal models. In addition, the germinated fermented soybean extract of the present invention increases the mineral content in bones, thereby significantly increasing the bone density, and has an effect of increasing the thickness and number of spongy bones. Furthermore, the germinated fermented soybean extract of thepresent invention has an effect of relieving symptoms of menopause.

Description

technical field [0001] The present invention relates to a germinated and fermented bean extract containing coumestrol and a composition containing the same, which has the effect of protecting liver cells and increasing the bone density. In more detail, using germinated fermented bean extract as an ingredient in natural foods that has the effect of improving lipids in the body and menopausal disorders, hepatotoxicity that occurs during menopausal disorders was evaluated by in vitro antioxidant activity and cell survival rate and Blood tests of animal models, measurement of MDA (malone dialdehyde), GST (glutathione s-transferase, glutathione S-transferase), GSH (reduced glutathione), SOD (superoxide Dismutase, Superoxide dismutase), catalase (Catalase), etc. to verify the effect of protecting liver cells. In addition, in the present invention, the germinated and fermented bean extract was used as a sample, and in order to verify the effect of improving the bone loss that occurs...

Claims

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Application Information

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IPC IPC(8): A61K36/48A23L33/105A61K31/35A61K31/352A61K31/34A61K9/08A61K9/20A61K9/48
CPCA61K36/48A61K31/352A61P15/12A61P19/10A61P1/16A61P3/04A23L33/105A61K2236/19A23V2002/00A23V2200/30A23V2200/31A23V2200/32A23V2200/306A23V2250/21A61K9/08A61K9/20A61K9/48A61K31/34A61K31/35
Inventor 李东成
Owner HUBIO
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