73 results about "Licochalcone A" patented technology

Cosmetic hair- and / or body-cleansing compositions comprising licochalcone A or an extract of Radix Glycyrrhiza inflata and one or more surfactants and, optionally, further comprising cosmetic and / or dermatological active ingredients, auxiliaries and additives.

A cosmetic or pharmaceutical preparation comprising licochalcone A and one or more hydrocolloids. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

A synergistic clean extraction method of effective components in licorice root adopts a solvent to synchronously extract the effective components in licorice root in order to obtain a total extract product, and the total extract product is separated one by one according to physical and chemical properties of all the components. The method comprises the following steps: 1, preparing the total extract product of the licorice root; 2, separating water-soluble and fat-soluble components; 3, separating glycyrrhizic acid from licorice pigments, licorice glucose and licorice polysaccharides in the water-soluble components; 4, separating the licorice pigments from the licorice glucose and the licorice polysaccharides; 5, separating the licorice glucose from the licorice polysaccharides; 6, separating and purifying glabridin in the fat-soluble components; 7, separating and purifying liquiritin and isoliquiritin in the fat-soluble components; 8, separating and purifying isoliquiritigenin and liquiritigenin in the fat-soluble components; 9, separating and purifying licochalcone A in the fat-soluble components; 10, separating and purifying licorice lignin in the fat-soluble components; and 11, separating and purifying licorice cellulose in the fat-soluble components.

A cosmetic or pharmaceutical preparation comprising licochalcone A and phenoxyethanol. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

The invention discloses the applications of compounds, selected from quercetin, chrysophanic acid, digicitrine, formononetin, honokiol, berberine, kaempferol, bergenin, deoxyepinephrine and licochalcone A, as well as derivatives thereof, in preparation of medicines applied to methods that are used for promoting stem cell proliferation, delaying senescence of stem cells, promoting differentiation of the stem cells into osteoblasts, chondrocytes and adipocytes, enhancing the vascularization capability of the stem cells and / or improving exercise tolerance of mice. The invention also discloses that the compounds can be combined with vitamin C for application.

The invention discloses a whitening black-removing compound which contains the following components by weight percent: 1-10% of nicotinamide, 1-5% of licochalcone A, 1-10% of arbutin, 0.5-1.5% of bletilla root extract, 0.5-1.5% of atractylodes root extract, 0.05-0.3% of pearl extract, 0.05-0.3% of ginseng extract, 0.01-0.5% of nymphaea alba flower, 0.01-0.5% of ligusticum root, 20-40% of glyceroland the balance of water. The whitening black-removing compound is capable of whitening and removing black at three aspects of melanin synthesis, transferring and removing, so that the whitening effect can be greatly promoted.

The invention discloses an antibiosis use of licochalcone A. Experiments prove that the licochalcone A can be used to prepare antibiosis medicines, food additives or cosmetics due to its antibiosis effect.

The invention relates to a preparation process for high pure licochalcone A. The technique procedures of the invention are as follows : at first, the liquorice is pulverized and then extracted 1 to 3 times with the solvent using cold percolation, warm soaking or refluence extraction process; the extraction liquid is emerged and made a pressure reduction concentration; then the extraction liquid is extracted again by the organic solvent and the extracted liquid is made a pressure reduction concentration, and the organic solvent is reclaimed, the concentrate adopts the column chromatography separation and is cleaned by water, alcohol, methanol, acetone or the mixing liquid thereof, the effluent of licochalcone A is collected to be concentrated and crystallized by the organic solvent to obtain the high pure licochalcone A. The invention has simple process, less procedures, the solvent, the column stuffing as well as the eluent which all can be repeatedly used, and is a preparation process with low cost, high purity, easy magnification and recycle type; the acquired licochalcone A is orange needle crystals with no lower than 90 percent of purity.

The invention relates to a preparation method of licochalcone A, which is convenient to operate, less in pollution and low in energy consumption. The method comprises the following steps: smashing liquorice; adding the smashed liquorice into a CO2 supercritical extractor; adding ethanol as entrainer; and carrying out extracting to obtain extract; adding the extract to a polyamide chromatographic column; adding ethanol-water mixed solvent as eluant for eluting, wherein the ratio of ethanol to water is 2:1; collecting eluent; and recovering the solvent, adding acetone for crystallization, washing and drying, thus obtaining the licochalcone A. The licochalcone A prepared by the method has high purity and is easy to realize industry magnification.

The present invention relates to a compound licochalcone A (5-(1,1-dimethylallyl)-4,4'-dihydroxy-2-methoxychalcone) and glycyrrhiza inflate betal flavone extract, glycyrrhiza glabra Li flavone extract and glycyrrhiza kansuensis changet peng flavone extract containing said licochalcone A. Said invention also provides the application of licochalcone A and above-mentioned flavone extracts or their mixture in preparation of medicine for curing oral diseases, such as halitosis, caries and gingivitis, reducing calculus and dental plaque and whitening tooth, etc.

A cosmetic or pharmaceutical preparation comprising licochalcone A and one or more hydrocolloids. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

The invention relates to a method for measuring seven functional components of liquorice in cosmetics. The method comprises the following steps: adding 60 to 80 percent of methyl alcohol into a sample to be tested, performing repeated ultrasonic extraction and centrifugation, combining centrifugal supernate, adding the supernate into a rotary evaporating flask, performing rotary evaporation till constant volume is not exceeded, transferring the methyl alcohol and the sample into a graduated tube, metering the volume through methyl alcohol, filtering through a filter membrane, performing liquid chromatography measurement on filtrates, adopting a diode array detector, using octadecylsilane chemically bonded silica as a filler column, detecting at 190 to 400 nm, using an acetonitrile-phosphoric acid solution as a flowing phase, performing gradient elution, and collecting seven functional components which are liquiritin, isoliquiritin, glycyrrhizin, dipotassium glycyrrhizinate (glycyrrhizic acid), licochalcone A, glabridin and glycyrrhetinic acid. The method is high in resolution ratio and sensitivity, good in selectivity, short in time, simple in sample treatment method, and suitable for the micro analysis of seven functional components of liquorice in the cosmetics, and fills a gap of the measurement of seven functional components of liquorice in the cosmetics.

The invention discloses new medical application of glycyrrhiza inflata ethanol extract and licochalcone A. The inventor discovers that glycyrrhiza inflata and other medical licorice root have obvious chemical ingredient difference, furthermore systematically researches the glycyrrhiza inflata ethanol extract and the important ingredient licochalcone A therein, and discovers that the glycyrrhiza inflata ethanol extract and the licochalcone A have remarkable activity in protecting oxidized cell injury, tissue injury and acute chemical liver injury. Based on the discovery, the extract and an active compound or pharmaceutically acceptable salt, ester and a solvate, a stereoisomer, tautomer, a prodrug and a mixture thereof can be used for preparing medicaments and health products for treating / preventing oxidative injury and / or acute chemical liver injury.

The invention discloses application of licochalcone A to preparation of a medicine for treating necrotic enteritis. A clostridium perfringens sliding motion inhibition test, a biofilm formation inhibition test and a chick necrotic enteritis model test verify that the licochalcone A has protective effect on chicken necrotic enteritis caused by infection of clostridium perfringens. Due to abuse of the traditional antibiotics and bacterial medicine resistance, the licochalcone A has the characteristics of high curative rate, no medicine resistance and no medicine residues, and the licochalcone Acan improve the selectivity of the used medicines and has important significance in developing new medicines when being used for treating the chicken necrotic enteritis.

The invention relates to a soluble micro needle with an anti-acne effect and a preparation method thereof. The micro needle comprises a substrate layer and a needle point arranged on the substrate layer. The micro needle is characterized in that the needle point is prepared from the following ingredients in percentage by mass: 8 to 15 percent of sodium hyaluronate, 1 to 5 percent of papain, 30 to40 percent of an anti-acne composition and the balance excipients; the anti-acne composition is prepared from chlorogenic acid, licochalcone A, lipo-hepinette, and epigallocatechin gallate according to the mass ratio of 1:(2 to 5):(10 to 18):(15 to 30); the substrate layer is prepared from polyvinylpyrrolidone. The prepared micro needle has the advantages of good anti-acne effect, use convenienceand the like.

The invention discloses application of licochalcone A in preparation of a medicine for resisting porcine epidemic diarrhea virus, wherein the mass percentage content of the licochalcone A is not lowerthan 97.65%, and the application dosage is 1-10 micrometers per liter; the licochalocone A has remarkable effect on resisting porcine epidemic diarrhea virus, is safe and with less toxic and side effects, and has low drug residue and no pollution.

The present invention provides gero-protective pharmaceutical compositions and methods, the compositions being adapted to enhance at least one of cell survival and cell metabolism in a mammalian subject, the pharmaceutical compositions include at least two of Withaferin a or its structural analogs, coumestrol, ginsenoside, quinidine, silymarin, licochalcone a, lipoic acid and apigenin, in a pharmaceutically effective amount.

The invention provides a method for preparing licochalcone A. The method comprises the following steps: culturing glycyrrhiza inflata hairy roots or glycyrrhiza inflata seedlings in a culture medium containing a DNA methyltransferase inhibitor for not less than three days, collecting roots of the glycyrrhiza inflata hairy roots or glycyrrhiza inflata seedlings, and extracting the licochalcone A. The culture medium containing the DNA methyltransferase inhibitor is used for culturing glycyrrhiza inflate seedlings or glycyrrhiza inflate hairy roots, so that the DNA methylation degree of the glycyrrhiza inflate seedlings or glycyrrhiza inflate hairy roots can be reduced; and genes which are originally silent or low in expression quantity and are beneficial to accumulation of licochalcone A are reactivated, so that the content of licochalcone A is quickly and effectively increased.

The invention discloses a microbial fermentation method for preparing licorice root fermentation liquor with high safety performance and whitening and anti-aging effects and a product. The method comprises the steps of inoculating an unfermented licorice root solution with activated yeast strains, and conducting fermentation for 35-45 h at the temperature of 25-35 DEG C, the pH value of 6.5-9.0 and the rotating speed of 80-160 r / min, so as to obtain the licorice root fermentation liquor. Researches find that by the adoption of the method, the content of glabridin and licochalcone A in the licorice root fermentation liquor can be reduced remarkably, and the content of the active ingredients isoliquiritigenin and isoliquiritoside which have MMPs inhibition and collagen stimulation effects is increased remarkably. Therefore, the licorice root fermentation liquor prepared with the method has broad application prospects in preparation of cosmetic products, especially cosmetic products with high safety performance and whitening and anti-aging effects.

The invention discloses whitening and skin moisturizing cream, which is prepared from the following raw materials in parts by weight: 40 to 60 parts of water, 2 to 6 parts of glycerol, 1 to 3 parts of1,3-butanediol, 1 to 5 parts of cyclopentasiloxane, 1 to 3 parts of surfactants, 0.02 to 0.06 part of ascorbyl tetraisopalmitate, 0.02 to 0.06 part of caprylic / capric triglyceride, 0.02 to 0.06 partof nicotinamide, 0.03 to 0.09 part of licochalcone A, 0.02 to 0.06 part of allantoin, 0.02 to 0.06 part of tocopheryl acetate, 1 to 2 parts of wool fat and 2 to 6 parts of mineral oil. The whitening and skin moisturizing cream has the efficient hydroxy radical inactivation effect; after the use, a user obviously feels comfortable and soft; no greasy feeling is caused; melanin on the skin can be effectively eliminated; the skin whitening effect is achieved; the skin can become smooth, bright and beautiful; the wrinkle regeneration is avoided; no irritation is caused on the skin; the obvious sun-screen restoration and skin moisturizing effects are achieved.

The invention discloses facial mask liquid for repairing couperose skin and a preparation method of the facial mask liquid. The facial mask liquid is prepared from the following components in parts byweight: 16 to 24 parts of protein growth factor, 2 to 4 parts of licochalcone A, 30 to 50 parts of lactobacillus / vigna radiata seed extract / glutamic sodium fermented product filtrate, 6 to 10 parts of vitamin C ethyl ether, 8 to 12 parts of vitamin A, 4 to 6 parts of vitamin B2, 9 to 15 parts of ceramide, 3 to 5 parts of nicotinamide, 10 to 20 parts of rose hydrosol, 15 to 23 parts of lanolin, 4to 8 parts of arginine, 12 to 16 parts of butanediol, 7 to 11 parts of D-panthenol, 0.1 to 0.3 part of folic acid, 24 to 32 parts of hyaluronic acid, 0.5 to 3.5 parts of tea polyphenol, 1 to 14 partsof thickening agent and 80 to 100 parts of deionized water. The protein growth factor is prepared from the following components in percentage by weight: 20 to 28 percent of oligopeptide-1, 10 to 14 percent of oligopeptide-2, 18 to 22 percent of oligopeptide-3, 26 to 46 percent of oligopeptide-5 and 6 to 10 percent of palmitoyl tripeptide-8. The facial mask liquid disclosed by the invention has theadvantages that elasticity and functions of facial capillary are favorably restored and blood circulation is improved; in addition, intercellular matrix is replenished, cuticle is reconstructed, fibroblast proliferation is promoted and damaged epidermal barrier is repaired, so that the couperose skin can be cured from the root.

A nutritional supplement comprises components (A), (B) and (C), and optionally, additional component(s) (D). The nutritional supplement can activate a subject's antioxidant system, more specifically the subject's antioxidant response element (ARE). In one embodiment, the nutritional supplement comprises: (A) glabridin; (B) licochalcone A; and (C) licorice root flavonoids. In another, the nutritional supplement comprises: (A) a first licorice root extract comprising glabridin; (B) a second licorice root extract comprising licochalcone A; and (C) a third licorice root extract comprising flavonoids. Components (A), (B) and (C) are in a combined amount sufficient to activate the subject's antioxidant system after ingestion. In addition, components (A), (B) and (C) are present in a weight ratio (A:B:C) such that their combined effect is greater than the sum of their separate effects regarding activation of the subject's antioxidant system after ingestion of the nutritional supplement.

The invention discloses a new medicinal application of effective components and derivatives in Glycyrrhiza uralensis. The effective components and derivatives in Glycyrrhiza uralensis include liquiritin, glycyrrhizin, glycyrrhetinic acid, isoliquiritigenin, licochalcone A, glycyrrhizic acid and its derivative glycyrrhizic acid monoammonium salt, and the effective components and derivatives in Glycyrrhiza uralensis are used for preparing anticancer drugs. As that effective component in Glycyrrhiza uralensis and its derivative can induce tumor cells to produce immunogenic cell death. The invention provides a tumor treatment drug with definite curative effect, safety, convenience and wide sources, which can be combined with one or more pharmaceutically acceptable carriers or excipients to prepare pharmaceutical compositions or preparations of active components in licorice and derivatives thereof, it provides new drugs for tumor immunotherapy and is of great significance for improving tumor therapeutic effect and quality of life of patients. The effective components come from fruits, vegetables and medicinal materials, with small side effects, low cost and convenient popularization anduse.

A cosmetic or pharmaceutical preparation comprising licochalcone A and phenoxyethanol. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

The invention discloses a method for extracting high-purity licochalcone A. The method belongs to the field of separation and purification of natural substances, and comprises the following steps of crushing liquorice, extracting with a solvent for multiple times, concentrating and evaporating an extracting solution to dryness, adding water into an obtained crude product, dispersing, extracting with a solvent, evaporating an extracting solution to dryness, separating with a column, and collecting a licochalcone A part, and drying by distillation to obtain high-purity licochalcone A with the purity of 98%, and recrystallizing to obtain licochalcone A with the purity of 99% or above. The process is simple, the solvent can be recycled and reused, the cost is low, the purity is high, and industrial production is easy.

The invention provides an oral spray for prevention and auxiliary treatment on periodontitis and a preparation method of the oral spray. The oral spray provided by the invention comprises the following raw materials: epigallocatechin gallate, theaflavin, procyanidine, licochalcone A, farrerol, luteolin, ferulic acid, menthol, notoginsenoside R1, xylitol, citric acid, rheum emodin, ginsenoside, ethanol and sterile water. The oral spray provided by the invention is free of toxic or side effect, has relatively good growth inhibition and sterilization function upon fusobacterium nucleatum, gingivaporphyrin monoucleosis, actinobacillus actinomycetemcomitans and the like in pathogenic bacteria of periodontitis, meanwhile is capable of inhibiting pathogenic bacterium polymerization and formationof biological membranes, has an antibacterial adhesion function, and meanwhile has the functions of inflammation elimination and alveolar resorption prevention.

Disclosed is a composition comprising a plurality of active botanical ingredients, each predominantly associated with an in-use beneficial effect on an animate or inanimate substrate, where said composition comprises: (i) a first aqueous extract of a material derived from a first plant, said first extract comprising a first amount of a first active botanical ingredient; (ii) a second aqueous extract of a material derived from a second plant whose genus is not the same as the first plant, said second extract comprising a first amount of a second active botanical ingredient; (iii) an additional amount of said first active botanical ingredient; and (iv) an additional amount of said second active botanical ingredient; where each said additional amount is included by spiking said composition or the corresponding aqueous extract selectively with said first and said second active botanical ingredients, such that ratio of said first amount of said first active botanical ingredient to its corresponding additional amount and ratio of said first amount of said second active botanical ingredient to its corresponding additional amount in the composition is from 1:1 to 1:3000 parts by weight, wherein said composition is substantially free of non-aqueous extracts of any material derived from said first or said second plant wherein said first plant is Atractylodes macrocephala and said first active botanical ingredient is atractylenolide I, II or III and further wherein said second plant is Glycyrrhiza uralensis, Glycyrrhiza inflata or Glycyrrhiza glabra and said second active botanical ingredient is licochalcone A or glabridin.

The invention discloses application of licochalcone-A in preparation of an anti-haemophilus-parasuis drug. The anti-haemophilus-parasuis drug comprises the following components: licochalcone-A, pharmaceutically acceptable excipients, and auxiliary substrates. Tests have proven that inhibitory effects of licochalcone-A offielddifferent concentrations on haemophilus parasuis in vitro are not significantly different; and licochalcone-A of different concentrations has no effect on formation of bacterial biofilm. In vivo test results have suggested that immune organ indexes of mice are appropriately enhanced by licochalcone-A with abundance and structure of intestinal flora in the mice improved, so that, the licochalcone-A is capable of improving ability of the mice to eliminate haemophilus parasuis, enhancing ability of infection protection of the mice as well as delaying time of death of the mice infected with haemophilus parasuis.