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Method for separating, extracting and purifying nonyl alcohol from plant and its application

A technology of chinonyl alcohol and medicinal plants, applied in the separation/purification of hydroxyl compounds, organic chemistry, etc., can solve the problems of glucocorticoids due to side effects of hormones, neutropenia and thrombocytopenia, and easy recurrence

Inactive Publication Date: 2002-11-20
林文翰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] ②Indomethacin has a stronger effect than aspirin, but it is contraindicated for patients with peptic ulcer and liver and kidney insufficiency
[0009] ③Butazone can be effective within 1 week, but it can cause granulocytes and thrombocytopenia
[0011] 2. Glucocorticoids have large side effects and are prone to relapse after discontinuation, so they are generally used when others are ineffective
[0015] The western medicines mainly used at present all have different degrees of toxic and side effects or other side effects. The present invention overcomes the inconvenience of directly using traditional Chinese medicines to treat diseases in the prior art, and provides a method for obtaining the active ingredient chinonol from traditional Chinese medicines. Using chinonyl alcohol as a lead compound, it provides a good medicine with low toxicity and obvious efficacy for the treatment of diseases such as anti-rheumatoid arthritis, analgesia, antibacterial, antimalarial, antihypertensive, and vasodilation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Separation, extraction and purification of chinonol by the following methods and steps:

[0037] 1. Take 1 kg of the naturally dry aboveground part of the raw material medicinal material Scutellaria chinensis Glandstem stalk, crush it, put it into a heating reflux bottle, add 8 liters of petroleum ether, heat up to reflux, and the first reflux time is 2 hours; cool , poured into a Buchner funnel and filtered under reduced pressure to remove the reflux liquid. Add 6 liters of petroleum ether to the filter residue, repeat the above reflux once, and filter under reduced pressure to remove the reflux liquid.

[0038] 2. Add 6 liters of 95% ethanol to the filter residue obtained in step 1, heat up to reflux for 2 hours, cool, filter under reduced pressure to remove the reflux liquid, and repeat the above-mentioned reflux process twice for the filter residue, and combine the filtrates. The filtrate was controlled on a rotary evaporator at a temperature of 45° C., concentrate...

Embodiment 2

[0044] Separation, extraction and purification of chinonol by the following methods and steps:

[0045] 1. Take 1 kg of the natural dry aboveground part of the raw material medicinal material, Scutellaria chinensis Glanderia stalk, crush it, add it to a heating reflux bottle, add 8 liters of cyclohexane, and heat up to reflux, and the first reflux time is 2 hours; After cooling, pour it into a Buchner funnel and filter under reduced pressure to remove the reflux liquid. Add 6 liters of cyclohexane to the filter residue, repeat the above reflux once, and filter under reduced pressure to remove the reflux liquid.

[0046] 2. Add 6 liters of solvent acetone to the filter residue obtained in step 1, heat up to reflux for 2 hours, cool, filter under reduced pressure to remove the reflux liquid, repeat the above-mentioned reflux process twice for the filter residue, and combine the filtrates. The filtrate was controlled on a rotary evaporator at a temperature of 40° C., concentrate...

Embodiment 3

[0052] Separation, extraction and purification of chinonol by the following methods and steps:

[0053] 1. Take 1 kg of the natural dry aboveground part of the raw material medicinal material, Scutellaria chinensis Glanderia stalk, crush it, add it to a heating reflux bottle, add 8 liters of cyclohexane, and heat up to reflux, and the first reflux time is 2 hours; After cooling, pour it into a Buchner funnel and filter under reduced pressure to remove the reflux liquid. Add 6 liters of cyclohexane to the filter residue, repeat the above reflux once, and filter under reduced pressure to remove the reflux liquid.

[0054] 2. Add 6 liters of methanol to the filter residue obtained in step 1, heat up to reflux for 2 hours, cool, filter under reduced pressure to remove the reflux liquid, repeat the above reflux process twice for the filter residue, and combine the reflux liquid. The filtrate was controlled on a rotary evaporator at a temperature of 45° C., concentrated under reduc...

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Abstract

The present invention relates to a method for separating, extracting and purifying compound add nonanol from medicinal plant siegesbeckia and the application of said compound in preparation of medicine. The medicine preparation made up by using add nonanol as leading compound possesses the effect of resisting rheumatoid arthritis, stopping pain, resisting bacteria, antimalarial, reducing blood pressure and relaxing blood vessel, etc. and possesses the advantages of low toxicity and obvious medicine effect.

Description

technical field [0001] The present invention relates to a kind of method for separating, extracting and purifying compound kirenol (kirenol) from plants, particularly the method for separating, extracting and purifying kirenol from the leather of medicinal plant Siberia chinensis, and the present invention also relates to the method of kirenol Applications, especially in anti-rheumatoid arthritis, analgesic and other drugs. Background technique [0002] Herbasieges beckiae (Herbasiegesbeckiae) is a plant of the genus Herbasiegesbeckiae (compositae, asteraceae). It is a traditional Chinese medicine in my country. There are mainly three varieties in China, namely Siegesbeckia orientails L., Siegesbeckia pubescens Makino and Siegesbeckia glabrescens Makino. [0003] According to the "Pharmacopia of the People's Republic of China" (compiled by the Pharmacopoeia Committee of the Ministry of Health of the People's Republic of China, Chemical Industry Press, 1995 Edition, Part 1 P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/74C07C35/42
Inventor 林文翰付宏征李军
Owner 林文翰
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