Skin wound biological induced active dressing, preparation method and application thereof

Abstract

The invention provides a medical dressing for protecting skin wounds and promoting repairing, an application of the medical dressing and a preparation method of the medical dressing. The medical dressing comprises a biological plural gel film dressing and a medical polyurethane adhesive film; the biological plural gel film dressing is composed of raw materials of a framework material synthesized by polyanion substances and polycation substances, hyaluronic acid, polypeptide and bonding polypeptide; and the potential of hydrogen (pH) value of the biological plural gel film dressing is 5.8-6.4. The medical dressing for protecting the skin wounds and promoting repairing of the skin wounds has the advantages of wound covering medical dressings, more importantly, by means of synergistic actions of the bonding polypeptide and the hyaluronic acid, the structural designs of medical dressing materials are optimized, and additional growth factors or living cells are not required for enabling the medical dressing materials to have functions of in-situ inducing tissue regeneration and repair.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a medical dressing for skin wound protection and repair promotion, its application and a method for preparing the medical dressing. Background technique [0002] The wound covering dressings currently used clinically mainly include three categories: traditional dressings, natural biological dressings, and synthetic biological dressings. Traditional dressings such as gauze and cotton pads are commonly used clinically. Their advantages are: wound protection, water absorption, simple production, and low price. However, they cannot keep the wound moist and the wound healing is delayed. The reaction affects wound healing, wound granulation tissue is easy to grow into the mesh of gauze, and it is easy to damage when changing dressings, which affects wound healing and causes pain. Pathogens can easily penetrate through dressings and cause wound infection. Natural biological dressings include autol...

AI Technical Summary

Problems solved by technology

Traditional dressings such as gauze and cotton pads are commonly used clinically. Their advantages are: wound protection, water absorption, simple production, and low price. However, they cannot keep the wound moist and the wound healing is delayed. The reaction affects wound healing, wound granulation tissue is easy to grow into the mesh of gauze, and it is easy to damage when changing dressings, which affects wound healing and causes pain. Pathogens can easily penetrate through dressings and cause wound infection. Natural biological dressings include autologous skin, allogeneic skin, irradiated pig skin, amniotic membrane, etc.

At present, the most ideal way to cover wounds is to transplant autologous skin, but for patients with large-scale trauma, the source of autologous skin is seriously insufficient; the permeability and adhesion of allogeneic skin are similar to those of patients' skin, which can effectively reduce antigenicity and reduce Rejection, but there are clinical and ethical issues such as high price, limited sources, and high requirements for storage conditions; although heterogeneous skin dressings have relatively wide sources and low prices, they have problems such as antigenicity, irritation, and viral infection, and are not Suitable for industrial production; synthetic biological dressings mainly include chitin (or chitosan) dressings, alginic acid dressings, silk fibroin dressings, bacterial cellulose dressings, and collagen dressings

Chitin (or chitosan) dressings have good tissue compatibility, good hemostatic function, and strong anti-infection ability, but poor adhesion and compliance; alginic acid dressings have high hygroscopicity and can keep the wound moist. The environment and cost are low, but it is easy to harden and cause wound re-injury; silk fibroin dressings have good cell and tissue affinity, and good oxygen and gas permeability, but their water absorption, toughness, mechanical properties and antibacterial properties need to be improved ; Bacterial cellulose dressings have no immunogenicity, good water and air permeability, tight adhesion with the wound surface, strong mechanical strength and plasticity, but lack an effective fermentation system to produce large-scale and low-cost dressings; collagen dressings are biocompatible It has good properties, has hemostasis, promotes coagulation, and promotes cell division and differentiation, but its stability is relatively weak, its elasticity is poor, its quality is brittle, it is not resistant to water, and it is derived from animals, so there is a risk of infection

The development of biological dressings is rapid, and various biological dressings are constantly emerging. Although various biological dressings have good performance in one aspect, they all have more or less defects. good dressing

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