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Compound mouthwash

A mouthwash and compound technology, applied in the field of mouthwash, can solve problems such as the negative impact on prognosis, the economic impact of mucositis, etc., and achieve the effect of reducing the incidence rate and shortening the length of hospitalization

Pending Publication Date: 2021-10-22
中国人民解放军西部战区总医院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Severe mucositis may require dose reduction of chemotherapy or interruption of radiation therapy, which may negatively affect prognosis
Furthermore, mucositis has a significant economic impact owing to the costs associated with symptom management, nutritional support, management of secondary infections, and hospitalization

Method used

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Embodiment Construction

[0014] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0015] Although direct cellular injury induced by chemotherapy and / or RT (radiotherapy) initiates the process, evidence suggests that the pathogenesis of mucositis is more complex. It could be a five-stage model. Second messengers, proinflammatory cytokines and pathways, and metabolic byproducts of colonizing microbes are all thought to play important roles in amplifying tissue damage.

[0016] Although a variety of interventions for mucositis are available, many of which are available over-the-counter or over-the-counter or sold a...

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Abstract

The invention discloses compound mouthwash. The compound mouthwash is prepared by adding 10mg of dexamethasone sodium phosphate injection, 113mg of recombinant human interleukin for injection and 0.4 g of lidocaine injection into 200ml of sterilizing water for injection, and uniformly mixing the materials. The compound mouthwash can reduce the incidence rate and infection rate of chemoradiotherapy-related oral mucositis and shorten the hospitalization time.

Description

technical field [0001] The invention relates to the technical field of mouthwash, in particular to a compound mouthwash. Background technique [0002] Mucositis is damage to the mucosa secondary to cancer treatment and can be seen in the mouth, pharynx, larynx, and esophageal regions, as well as in other areas such as the gastrointestinal tract. Mucositis can be caused by chemotherapy and / or radiation therapy. It occurs in approximately 20% to 40% of patients receiving conventional chemotherapy, 80% of patients receiving high-dose chemotherapy as a hematopoietic stem cell transplant (HSCT), and almost all patients receiving radiation therapy to the head and neck. Among them, oral mucositis manifests as erythema and / or ulceration of the oral mucosa. In addition, the mucous membranes of the pharynx, larynx, and esophagus are also at risk for developing mucositis, especially in patients receiving radiation therapy to the head and neck. Patients often cannot tolerate such pai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/20A61K9/00A61P1/02A61P29/00A61K31/573A61K31/167
CPCA61K31/573A61K38/2073A61K31/167A61K9/006A61P1/02A61P29/00A61K2300/00
Inventor 汪广杰储碧心黄娟
Owner 中国人民解放军西部战区总医院
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