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Nano calcium phosphate-loaded idebenone particles as well as preparation method and cosmetics thereof

A nano-calcium phosphate, idebenone technology, applied in cosmetics, cosmetic preparations, cosmetic preparations and other directions, can solve the problems of poor stability of active substances, loss of stable active substances, easy rupture of liposomes, etc. Regular appearance, excellent biosafety, and easy-to-obtain effects

Active Publication Date: 2020-09-08
HUNAN YUJIA COSMETICS MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, idebenone has the following disadvantages: it is lipophilic and difficult to dissolve or disperse in aqueous solution; it enters the skin too fast, which will cause strong irritation; the molecule is unstable, and it is easy to degrade and lose weight under heating conditions. live
However, the relative stability of liposome-encapsulated active substances is relatively poor. In strong shear force, high temperature, and strong ionic solution, liposomes are easily broken and lose their role in stabilizing active substances.

Method used

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  • Nano calcium phosphate-loaded idebenone particles as well as preparation method and cosmetics thereof
  • Nano calcium phosphate-loaded idebenone particles as well as preparation method and cosmetics thereof
  • Nano calcium phosphate-loaded idebenone particles as well as preparation method and cosmetics thereof

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preparation example Construction

[0038] One embodiment of the present invention provides a method for preparing nano-calcium phosphate-loaded idebenone particles, comprising the following steps S10-S30.

[0039] S10, mixing the sodium polyacrylate and the calcium ion solution to undergo a complexation reaction to obtain a first mixed solution.

[0040] Specifically, sodium polyacrylate is added into the calcium ion solution, stirred and mixed for 2 hours to 6 hours, and complexation reaction forms a stable carboxyl-calcium ion complex. It can be understood that sodium polyacrylate can be solid powder or liquid.

[0041] In some embodiments, the concentration of calcium ions in the calcium ion solution is 0.01 mol / L-0.1 mol / L, and the dosage ratio of sodium polyacrylate to calcium ion solution is (1-10) mg:1 mL.

[0042]Further, the concentration of calcium ions in the calcium ion solution is 0.01 mol / L-0.05 mol / L, and the dosage ratio of sodium polyacrylate to calcium ion solution is (4-7) mg:1 mL. More pre...

Embodiment 1

[0066] The preparation of embodiment 1 calcium phosphate carrier

[0067] Prepare sodium polyacrylate aqueous solution and calcium chloride solution, the concentration of calcium ions in the solution is 0.01mol / L, the addition amount of sodium polyacrylate is 6mg / mL, and the molecular weight is 30000Da. After the two are compounded, a stable carboxyl group / calcium ion complex system is formed, and the mixing time is 2 hours.

[0068] Prepare a phosphate solution with a solution concentration of 0.06mol / L, and pre-adjust the pH to 8-10 with ammonia water. The mixed solution of the carboxyl-calcium ion complex system was poured into the phosphate solution, the stirring speed was controlled at 300 rpm, and the reaction temperature was 25°C. Two groups of parallel experiments were done, and the reaction time was set to 12hr and 24hr respectively. Collect the reacted particles, that is, the nano-calcium phosphate carrier, and perform physical and chemical characterization on it. ...

Embodiment 2

[0070] Preparation of embodiment 2 calcium phosphate carrier

[0071] Prepare sodium polyacrylate molecular aqueous solution and calcium chloride solution, the concentration of calcium ions in the solution is 0.01mol / L, the addition amount of sodium polyacrylate is 6mg / mL, and the molecular weight is 30000Da. After the two are compounded, a stable carboxyl group / calcium ion complex system is formed, and the mixing time is 2 hours. Prepare a phosphate solution with a concentration of 0.06mol / L, and pre-adjust the pH to 8-10 with ammonia water. The mixed solution of the carboxyl-calcium ion complex system was poured into the phosphate solution, the stirring speed was controlled at 300 rpm, and the reaction time was 24 hours respectively. Two sets of parallel experiments were done, and the reaction temperatures were set at 30°C and 80°C, respectively. Collect the reacted particles, that is, the nano-calcium phosphate carrier, and perform physical and chemical characterization o...

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Abstract

The invention relates to nano calcium phosphate-loaded idebenone particles as well as a preparation method and cosmetics thereof. The preparation method of the nano calcium phosphate-loaded idebenoneparticles comprises the following steps: mixing sodium polyacrylate and a calcium ion solution, and carrying out complexation reaction to obtain a first mixed solution; mixing the first mixed solutionwith a phosphate solution, controlling the molar ratio of calcium atoms in the first mixed solution to phosphorus atoms in the phosphate solution to be (1.5-1.8):1, and performing reaction for 12-24hours at a temperature of 25-90 DEG C to obtain a second mixed solution containing calcium phosphate particles; and mixing an ethanol solution of idebenone with the second mixed solution for loading to obtain the nano calcium phosphate-loaded idebenone particles. The nano calcium phosphate-loaded idebenone particles prepared by the method can be well dispersed in water, are good in stability, andcan realize controlled release under the weakly acidic condition of skin.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to nano calcium phosphate loaded idebenone particles, a preparation method thereof and cosmetics. Background technique [0002] The chemical name of idebenone is 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, and the structure of idebenone is similar to coenzyme Q10. Therefore, it can also be used as a powerful antioxidant in the field of cosmetics. It has the functions of efficiently scavenging free radicals, inhibiting lipid peroxidation, inhibiting inflammation, inhibiting DNA damage, photoprotection, and reducing pigmentation. It is an ideal cosmetic active substance. . However, idebenone has the following disadvantages: it is lipophilic and difficult to dissolve or disperse in aqueous solution; it enters the skin too fast, which will cause strong irritation; the molecule is unstable, and it is easy to degrade and lose weight under heating conditions. live. Th...

Claims

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Application Information

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IPC IPC(8): A61K8/35A61K8/24A61K8/81A61Q19/00
CPCA61K8/24A61K8/355A61K8/8147A61K2800/413A61K2800/52A61Q19/00
Inventor 戴跃锋何广文马晓瑜颜少慰
Owner HUNAN YUJIA COSMETICS MFG CO LTD
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