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147results about How to "Formula stable" patented technology

Microsphere type embolic agent and preparation technology thereof

The invention provides a microsphere embolic agent, which is an elastic microsphere formed by the crosslink polymer of the functionalized macromolecules with the biocompatibility, and the particle size of the microsphere ranges from 1 Mum to 1500 Mum. The preparing technology includes the steps as follows: in a covalent link, linking a crosslinkable micromolecules with an acrylic acid structure on the polyvinyl alcohol, polyethylene glycol or polysaccharide macromolecules, forming the functionalized macromolecules; after that, the functionalized macromolecules and the monomer of the 2- acrylamide-2-methyl propanesulfonic acid undertakes opposite suspension polymerization, obtaining the crosslink polymeric microsphere embolic agent. The embolic agent has comparatively large retractility and elasticity, whose particle size is controllable and has perfect dispersiveness; moreover, the raw material is non-toxic and at the same time has good biocompatibility and stability. The preparing technology is a real chemosynthesis technology, whose material and preparing process does not produce any virus pollution, according with various requirements of the international embolic agent, which can replace various import and domestic expensive embolic agent products and is extensively applicable to various surgeries in the interventional radiology field.
Owner:SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD

Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin

InactiveUS6969515B2Optimize lytic activityOptimize applicationPeptide/protein ingredientsInorganic non-active ingredientsThrombolysisThrombotic occlusion
Methods of thrombolysis that allow the use of a fibrinolytic composition comprising reversibly inactivated acidified plasmin and the localized delivery of the plasmin to a vascular thrombotic occlusion are disclosed. Further disclosed is a method for administering a therapeutic dose of a fibrinolytic composition substantially free of plasminogen activator to a human or animal having a vascular thrombotic occlusion. The fibrinolytic composition includes a reversibly inactivated acidified plasmin substantially free of plasminogen activator. Intravascular catheter delivery of the fibrinolytic composition directly into or in the immediate vicinity of the thrombus is disclosed to minimize the systemic degradation of fibrin while retaining the maximum plasmin activity against the thrombus. The method is applicable to the dissolution of thrombi in artificial devices, e.g., hemodialysis grafts.
Owner:GRIFOLS THERAPEUTICS LLC

Preparation technology for microspheric embolization agent

The invention relates to a preparation technology for a microspheric embolization agent. The preparation technology is used for preparing elastic microspheres cross-linked and polymerized by functionalized macromolecules with biocompatibility, wherein the grain range of the microspheres is 1-1500mu m. The preparation technology comprises the following steps that: a cross-linkable micromolecule with a crylic acid structure is connected on a polyvinyl alcohol, polyethylene glycol or polyose macromolecule in form of a covalent bond to form a functionalized macromolecule; and reversed phase suspension polymerization is conducted to the functionalized macromolecule and a 2-acrylamide-2-methylpropanesulfonic acid monomer to prepare cross-linked and polymerized microspheric embolization agent. The embolization agent has the advantages that the flexibility and the elasticity are high, the grain is even and is controllable, the dispersity is good, the raw materials are nontoxic and the biocompatibility and the stability are good. The preparation technology is a pure chemical synthesis technology, no virus pollution is caused to the raw materials and the preparation process, the requirements on international embolization agents are satisfied, and the embolization agent can substitute for all kinds of imported or domestic expensive embolization agent products and can be widely used in surgeries in the field of interventional therapy.
Owner:SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD

Method for utilizing molecular sieve systhesis mother liquor

The invention provides a method for complete cyclic utilization of ITQ-2 molecular sieve mother liquor with zero discharge. The key points of the invention are as follows: ITQ-2 molecular sieve mother liquor undergoes separation at first, then a cetyl trimethyl ammonium bromide surfactant and alkali lye obtained from the separation are analyzed and determined, and finally the surfactant and alkali lye are reused as raw materials to reprepare ITQ-2 molecular sieves with a high degree of crystallization. According to the invention, a method of recycling mother liquor is formulated by ingeniously utilizing the rule of temperatures for a cetyl trimethyl ammonium bromide surfactant to crystallize and precipitate in the mother liquor. In the invention, ITQ-2 molecular sieve mother liquor is recycled, thereby reducing cost, protecting environment and enabling mother liquor recycle formula and the quality of the obtained products to be stabilized.
Owner:DALIAN UNIV OF TECH

Nonformaldehyde nonpoisonous adhesive and preparation method thereof

The invention discloses a nonformaldehyde nonpoisonous adhesive and a preparation method thereof. The method comprises the following steps: firstly, adding proper water in a reactor which is provided with a stirring device; secondly, slowly adding polyvinyl alcohol into the reactor when the water is heated to 40 DEG C, heating the mixture to over 90 DEG C to ensure that the polyvinyl alcohol is completed dissolved, and preserving the heat for 1 hour; thirdly, cooling the materials to 70 DEG C, and adding polyalcohol, dispersant, emulsifier and aqueous solution of plasticizer into the reactor respectively, adding filler into the reactor, keeping stirring for 15 to 20 minutes to ensure that the raw materials are uniformly mixed, and filtering and discharging; and finally, uniformly mixing the raw materials with isocyanate in the proportion when the adhesive is used. The adhesive has simple production technology, can be subjected to both cold pressing and hot pressing, has low cost, and can completely realize non toxicity, harmlessness, greenness and environmental protection.
Owner:东营市盛基环保工程有限公司

Melt-Coated Dosage Forms

InactiveUS20110217289A1High active ingredient loadingGood stabilityBiocidePretreated surfacesSolventFoam Dosage Form
Formulations of sparingly water-soluble active ingredientscomprising carrier particles provided with active ingredient-containing coatings, the sparingly soluble active ingredients being embedded in coatings composed of amphiphilic copolymers, and the coatings being applied in the form of a solvent-free melt.
Owner:BASF SE

Quick disintegrating tablet in buccal cavity and production process thereof

The present invention relates to a quick disintegrating tablet in buccal cavity, comprising: a mixture, comprising a drug, a sugar (A), and an amorphous sugar (B), and after it is forming a tablet, it is humidified and dried. In particularly, the present invention relates to a quick disintegrating tablet in buccal cavity comprising: a mixture; comprising a drug, a sugar (A), and an amorphous sugar (B) which an amorphous-forming sugar in crystalline state is dissolved in a medicinally permitted solvent, the amorphous sugar is obtained from this solution by removing the solvent, and after it is forming a tablet, and it is humidified and dried. The tablet in the present invention is to provide stability against moisture at preserved, because the amorphous sugar changed to the crystalline state in a nonreversible reaction after it is humidified and dried in a manufacturing process. The tablet in the present invention is to further provide a design for the pharmaceutical preparation with respect to the stability of a drug, because the tablet is manufactured by one kind of a sugar and an amorphous sugar. Furthermore, the tablet in the present invention is to provide a production process by utilizing a common granulating machine and by utilizing a common tablet machine.
Owner:ASTELLAS PHARMA INC

Treatment process for expanded tobacco stems

ActiveCN104207322ASave warehouse spaceReduce mistTobacco treatmentAfter treatmentMicrowave
The invention relates to a treatment process for expanded tobacco stems, and belongs to the technical field of main material and auxiliary material processing in the tobacco industry. The microwave expanded tobacco stems are classified according to the thickness and / or the length, the expanded tobacco stems are placed into a pressure vessel, nitrogen with the purity being larger than 78% is connected into the pressure vessel, the tobacco stems and the nitrogen are evenly mixed, the pressure in the vessel is normal pressure to 8 MPa, the pressure is kept for 10 seconds to 40 minutes, the nitrogen in the pressure vessel is exhausted, the nitrogen can be recycled after purification and compressing treatment, the expanded tobacco stems after treatment are taken out, and the expanded tobacco stems are boxed or bagged in a classified mode for standby application; or moisture regain is conducted directly, so that products such as stem shreds, stem strip shreds and stem particles are manufactured. The microwave expanded tobacco stems treated through the process do not need to be stored any more, wooden odors and offensive odors in the tobacco stems are reduced, the tobacco stems cannot retract after moisture regain, and good elasticity and processing resistance are achieved. By means of the treatment process for the expanded tobacco stems, the requirement for the conditions such as warehouse space, manpower and logistics in the storage link is met, and therefore enterprise cost is greatly lowered.
Owner:姚波

Invert emulsions containing dhea

InactiveUS20090069279A1Good stabilityHigh dispersed volume fractionOrganic active ingredientsCosmetic preparationsEmulsionChemistry
Stable, recrystallization-resistant invert emulsions, suited, e.g., for preventing / treating the signs of chronological or actinic skin aging and for preventing / treating atrophy of the skin or mucous membranes, comprise a cosmetically / therapeutically effective amount of DHEA and / or chemical and / or biological precursor or derivative thereof, such invert emulsions also comprising a glycolic or hydroglycolic dispersed hydrophilic phase, a lipophilic continuous phase and an emulsifier having an HLB ranging from 2 to 7.
Owner:GALDERMA RES & DEV SNC

Engine coolant

The invention belongs to the technical field of chemical composition and particularly relates to an engine coolant. The engine coolant is prepared from the following substances in parts by weight: 45-55 parts of water, 25-35 parts of ethylene glycol, 5-8 parts of carboxylate, 5-12 parts of silicate stabilizer, 1-3 parts of nano oxide, 15-25 parts of propylene glycol, 1-5 parts of cesium formate, 3-5 parts of trimethylglycine, 5-8 parts of citric acid, 5-10 parts of ammonium citrate, 15-25 parts of molybdate, 8-12 parts of fatty acid, 0.5-0.8 part of antifoamer, 15-25 parts of potassium aminopropylsilicate, 5-10 parts of sodium octylsilicate, 5-8 parts of sodium benzoate, 3-5 parts of benzotriazole and 5-8 parts of methylbenzotriazole. The engine coolant provided by the invention is stable in formula, has long-acting bacteriostasis and anti-corrosion capability, is free of high-pollutional substances, cannot cause pollution to environments, has a very good corrosion inhibition action and can be used for effectively protecting engines.
Owner:青岛城轨交通装备科技有限公司

Slow-release preservative for fruits and vegetables and preparation method thereof

The invention relates to a slow-release preservative for fruits and vegetables. Adsorbing carrier adsorbing ethanol solution is loaded into a slow-release bag made of a polyethylene slow-release film, and the slow-release bag is then packaged by an air-permeable paper bag; the adsorbing carrier is powder or a shaped block, and the components of the adsorbing carrier include silica gel, diatomite and polydivinylbenzene porous adsorbent. The invention adopts the method of slowly releasing ethanol to inhibit the yellowing and rotting of fruits and vegetables, and the slow-release preservative has a remarkable effect in reducing the loss of the moisture of fruits and vegetables and inhibiting the growth of pathogenic bacteria and the aging of fruits and vegetables, and is a pollution-free, non-toxic and recyclable preservative product for fruits and vegetables. Compared with conventional products, the slow-release preservative can decrease the weight loss rate of different fruits and vegetables in the storage period by 10 to 30 percent and the rotting rate by 15 to 40 percent and prolong the shelf life by 30 to 50 percent, thus having a good preservation effect, and is applicable to the preservation of various fruits and vegetables. The formulation of a preparation method is simple, material resources are rich, the slow-release preservative is easy to prepare, the cost is low, and moreover, the slow-release preservative is convenient to use.
Owner:MICROBIOLOGY INST OF SHAANXI

Polylactic acid film blowing processing aid and preparation method and application thereof

InactiveCN103602048AImprove blown film processabilitySimple production processSilicon dioxideSurface modification
The invention discloses a preparation method of a polylactic acid film blowing processing aid, which comprises the following steps of (1) performing surface modification on nano silicon dioxide by use of a silane coupling agent, adding 0.01-6 weight parts of isocyanate substrate, and reacting at over 25 DEG C for more than 4 hours for secondary modification on the silicon dioxide; (2) taking the silicon dioxide after the secondary modification and a polylactic acid prepolymer as raw materials, preferably adding 50-200 parts of polylactic acid prepolymer into each part of silicon dioxide, introducing nitrogen into the reaction kettle, adding a metal lithium or tin catalyst, magnetically stirring at 25-140 DEG C, and heating and reacting for 1-24 hours to finally obtain solid powder; drying in a vacuum oven for 24 hours to obtain the polylactic acid film blowing processing aid. The invention also discloses an application of the polylactic acid film blowing processing aid. In the method disclosed by the invention, polylactic acid is directly grafted to the surface of the silicon dioxide to obtain polylactic acid-grafted silicon dioxide modified particles which are used as a polylactic acid processing aid, and the film blowing processability of polylactic acid is effectively improved.
Owner:SICHUAN UNIV
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