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Preparation technology for microspheric embolization agent

A preparation process and technology of embolic agent, which is applied in the field of preparation technology of microsphere embolic agent, can solve the problems of non-biocompatibility of embolic agent, different particle sizes of embolic agent, difficulty in identification and manipulation, etc., and achieve strong Target fixation, easy handling, stable positional effects

Active Publication Date: 2010-08-25
SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process is relatively simple, but the prepared embolic agent has different particle sizes and is difficult to separate. At the same time, the above-mentioned embolic agent is not biocompatible and has a hard texture, which is difficult to identify and manipulate in vivo and in vitro, and may cause incomplete embolism.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh molecular weight 2×10 4 -5×10 4 100g of polyvinyl alcohol was added to 500g of water, heated to 90°C, and stirred at a speed of 190r / min for 2 hours. After the polyvinyl alcohol was fully dissolved, the solution was cooled to room temperature, and then 1.2g of sodium acrylate was added. Stir at a speed for 6 h to fully react the above reactants. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature.

[0036] Weigh 1.63 g of 2-acrylamide-2-methylpropanesulfonic acid, 1.034 g of potassium persulfate and 17.3 g of water, stir and mix evenly, after the potassium persulfate is fully dissolved, add 40 g of the above-mentioned functionalized macromolecular intermediate, stir, Obtain a polymer monomer solution; take another 240 mL of butyl acetate, add 4.55 g of cellulose acetate, fully stir at a stirring speed of 240 r / min for 10 min, and then pass...

Embodiment 2

[0039] Weigh the molecular weight 3×10 4 ~4×10 4 200g of polyethylene glycol was added to 500g of water, heated to 80°C, and stirred at a speed of 100r / min for 2.5h. After the polyethylene glycol was fully dissolved, the solution was cooled to room temperature, 2.0g of butyl acrylate was added, and 120r / min was added. Stir at a speed of / min for 4 hours to make it fully react. After the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature.

[0040] Weigh 1.73 g of 2-acrylamide-2-methylpropanesulfonic acid, 1.044 g of potassium persulfate and 18.8 g of water, stir and mix evenly, after the potassium persulfate is fully dissolved, add 45 g of the above-mentioned functionalized polyvinyl alcohol intermediate, and stir , to obtain a polymer monomer solution; take another 270 mL of butyl acetate, add 4.60 g of cellulose acetate, fully stir at a stirring speed of 300 r...

Embodiment 3

[0043] Weigh molecular weight 4×10 4 ~5×10 4 100g of amylose was added to 500g of water, heated to 90°C, and stirred at a speed of 190r / min for 3h. After the amylose was fully dissolved, the solution was cooled to room temperature, and 1.2g of sodium acrylate was added at a speed of 190r / min. Stir for 6 hours to fully react, and after the reaction is completed, the reaction product is vacuum-dried to obtain a gel-like functionalized macromolecular intermediate, which can be stored below room temperature;

[0044] Weigh 1.83g of 2-acrylamide-2-methylpropanesulfonic acid, 1.054g of potassium persulfate and 20.3g of water, stir and mix evenly, after the potassium persulfate is fully dissolved, add 40g of the above-mentioned functionalized polyvinyl alcohol intermediate, and stir. Mix evenly to obtain a polymer monomer solution; take another 300 mL of butyl acetate, add 4.65 g of cellulose acetate, fully stir for 10 min at a stirring speed of 360 r / min, and then pass N 2 10min, ...

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Abstract

The invention relates to a preparation technology for a microspheric embolization agent. The preparation technology is used for preparing elastic microspheres cross-linked and polymerized by functionalized macromolecules with biocompatibility, wherein the grain range of the microspheres is 1-1500mu m. The preparation technology comprises the following steps that: a cross-linkable micromolecule with a crylic acid structure is connected on a polyvinyl alcohol, polyethylene glycol or polyose macromolecule in form of a covalent bond to form a functionalized macromolecule; and reversed phase suspension polymerization is conducted to the functionalized macromolecule and a 2-acrylamide-2-methylpropanesulfonic acid monomer to prepare cross-linked and polymerized microspheric embolization agent. The embolization agent has the advantages that the flexibility and the elasticity are high, the grain is even and is controllable, the dispersity is good, the raw materials are nontoxic and the biocompatibility and the stability are good. The preparation technology is a pure chemical synthesis technology, no virus pollution is caused to the raw materials and the preparation process, the requirements on international embolization agents are satisfied, and the embolization agent can substitute for all kinds of imported or domestic expensive embolization agent products and can be widely used in surgeries in the field of interventional therapy.

Description

technical field [0001] The invention relates to a preparation process of an embolic agent in the technical field of medical materials, in particular to a preparation process of a microsphere embolic agent used for interventional therapy to treat tumor diseases. Background technique [0002] As interventional therapy matures, it is being used more and more widely in the field of medical technology. The principle of interventional therapy is to use a high-definition medical imaging instrument to guide, insert a catheter into the tumor site in the human body through a small incision, and then perfuse antitumor drugs or block the blood supply to the tumor tissue through the blood supply artery, so that the tumor can be shortened for a short time. Internal necrosis, atrophy, to achieve the purpose of treatment. The key technology of interventional therapy lies in the selection of suitable particle embolic agents for blocking blood supply to tumor tissue. Mixed granules of paraf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/32A61K47/36A61K47/38A61P35/00
Inventor 姚飞孙小薇
Owner SUZHOU HENGRUI CALLISYN BIOLOGICAL MEDICINE TECH CO LTD
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