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Drug-loaded soluble microneedle patch and preparation method thereof

A soluble, micro-needle patch technology, applied in the field of micro-needles, can solve the problems that the drug dose cannot reach the therapeutic or immune dose promotion, and the drug load is small, and achieves stable and sustained release effect, good mechanical properties, and good swelling properties. Effect

Inactive Publication Date: 2019-05-03
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the main bottleneck in the development of microneedle technology is the small amount of drug loaded, and it is difficult to widely promote clinically because the amount of drug cannot reach the therapeutic or immune dose.

Method used

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  • Drug-loaded soluble microneedle patch and preparation method thereof
  • Drug-loaded soluble microneedle patch and preparation method thereof
  • Drug-loaded soluble microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A method for preparing a dissolvable microneedle patch, based on a microneedle mold, the microneedle mold contains several microneedle cavities, forming needles of the microneedle patch in the cavity, comprising the following steps:

[0048] S1, configure the mixed solution

[0049] Weigh a certain amount of polyvinyl alcohol, add an appropriate amount of purified water, heat in a water bath to 95°C, and stir mechanically for 3 hours to dissolve the polyvinyl alcohol, and the concentrations are 5%, 8%, 10%, 15%, and 20% respectively. PVA solution, set aside; take a certain amount of dextran respectively, add an appropriate amount of purified water, stir to make it dissolve, and obtain dextran solutions with concentrations of 5%, 8%, 10%, 15%, and 20%, respectively. Store in a refrigerator at 4°C for later use;

[0050] Configure a polyvinyl alcohol-dextran solution with a mass fraction of 10%~20% for the preparation of microneedle needles; configure a polyvinyl alcohol...

Embodiment 2

[0057] A method for preparing a soluble microneedle patch loaded with solid powder medicine by a sandwich method, based on a microneedle mold, the microneedle mold contains several microneedle cavities, forming needles of the microneedle patch in the cavity, comprising the following steps :

[0058] S1, configure the mixed solution

[0059] Weigh a certain amount of polyvinyl alcohol, add an appropriate amount of purified water, heat in a water bath to 95°C, and stir mechanically for 3 hours to dissolve the polyvinyl alcohol, and the concentrations are 5%, 8%, 10%, 15%, and 20% respectively. PVA solution, set aside; take a certain amount of dextran respectively, add an appropriate amount of purified water, stir to make it dissolve, and obtain dextran solutions with concentrations of 5%, 8%, 10%, 15%, and 20%, respectively. Store in a refrigerator at 4°C for later use;

[0060] Configure a polyvinyl alcohol-dextran solution with a mass fraction of 10%~20% for the preparation ...

Embodiment 3

[0068] Investigation of material swelling performance:

[0069] The effects of the ratio of polyvinyl alcohol: dextran and the number of freeze-thaws on the swelling performance of the material were investigated respectively. The results are shown in the attached image 3 As shown, the number of freeze-thaw cycles was 3 times, and the mass ratio of polyvinyl alcohol to dextran was 9:1 were the optimal conditions.

[0070] The specific operation is as follows: weigh the polyvinyl alcohol-dextran composite hydrogel dried to constant weight, put it into a beaker filled with purified water, and remove excess purified water with absorbent paper after a period of time , and weigh again until the swelling ratio remains unchanged. Swelling ratio calculation formula:

[0071] Swelling ratio =

[0072] Where Ws is the weight after swelling, and Wd is the weight at the previous moment.

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Abstract

The invention belongs to the technical field of a microneedle, and concretely relates to a drug-loaded soluble microneedle patch and a preparation method thereof. The microneedle patch of the presentinvention comprises a needle and a base patch, and the needle and the base patch are prepared by centrifuging, freezing and thawing a polyvinyl alcohol-glucan solution with different mass fractions, the drug powder is placed between the needle and the base patch to form the drug-loaded soluble microneedle patch. The microneedle patch has high safety, good solubility, good mechanical properties andlarge drug loading; the invention also provides the preparation method of the microneedle patch, the method is simple and easy, does not require special equipment and preparation processes, and is suitable for popularization. In the microneedle patch of the invention, a sandwich layer between the tip of the needle and a substrate can be loaded with a large amount of solid powder medicine, which greatly increases the drug loading amount of the microneedle patch, and achieves the purpose of transdermal sustained release of the drug or vaccine.

Description

technical field [0001] The invention belongs to the technical field of microneedles, and in particular relates to a drug-loaded soluble microneedle patch and a preparation method thereof. The soluble microneedle patch can effectively deliver powdered drugs into the skin. Background technique [0002] Microneedles are generally needle-shaped collections with a pointer length of less than 1000 µm. Microneedles can penetrate the skin and promote transdermal delivery of drugs without stimulating subcutaneous pain receptors and blood vessels, thereby reducing pain for patients. Microneedles can be divided into several categories: solid microneedles, dissolving microneedles, coated microneedles, and hollow microneedles. The materials of microneedles mainly include the following: [0003] Silicon material is widely used in the manufacture of solid microneedles and coated microneedles. It has good plasticity and can be easily prepared into microstructures of various shapes and size...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/00A61K47/32A61K47/36
Inventor 严琴英张正晗杨根生翁嘉绮张家豪郭钫元陈凡徐敏
Owner ZHEJIANG UNIV OF TECH
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