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Preparation method and application of novel fluorescent nano material with photodynamic therapy and sterilization functions

A technology of fluorescent nanomaterials and photodynamic therapy, which is applied in the fields of biomedicine, nanomaterials, and polymer materials, can solve the problems of long illumination time, high biological toxicity, complex synthesis path of PSs, etc. The effect of high toxicity and shortening the time of light exposure

Active Publication Date: 2022-05-13
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the deficiencies in the prior art, the technical problem to be solved in the present invention is to provide a simple synthesis method, degradable, high phototoxicity, and the like based on the shortcomings of the existing PSs synthesis path, such as complex synthesis path, high biological toxicity, and long illumination time. New fluorescent nanomaterials that require short illumination time and have both Type I and Type II PSs characteristics

Method used

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  • Preparation method and application of novel fluorescent nano material with photodynamic therapy and sterilization functions
  • Preparation method and application of novel fluorescent nano material with photodynamic therapy and sterilization functions
  • Preparation method and application of novel fluorescent nano material with photodynamic therapy and sterilization functions

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Embodiment 1

[0043] A method for preparing a novel fluorescent nanomaterial with photodynamic therapy and bactericidal functions, comprising the following steps:

[0044] Add 0.5g of o-phenylenediamine and 0.4g of L-cysteine ​​or D-cysteine ​​to 30mL of ultrapure water, stir evenly, add 1mL of 98wt% concentrated sulfuric acid, stir until the solution is clear and transparent, then transfer to 100mL The polytetrafluoroethylene reactor was placed in an oven with a temperature of 200°C and a reaction time of 3 hours.

[0045] The prepared fluorescent nanomaterial is a dark green solution.

Embodiment 2

[0047] The preparation method is similar to that of Example 1, except that the volume of sulfuric acid added is 2 mL.

Embodiment 3

[0049] A method for preparing a novel fluorescent nanomaterial with photodynamic therapy and bactericidal functions, comprising the following steps:

[0050] Add 0.5g of o-phenylenediamine and 0.4g of L-cysteine ​​or D-cysteine ​​to 30mL of ultrapure water, stir evenly, add 4mL of 98wt% concentrated sulfuric acid, stir until the solution is clear and transparent, then transfer to 100mL The polytetrafluoroethylene reaction kettle was placed in an oven with a temperature of 160°C and a reaction time of 3 hours.

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Abstract

The invention relates to the technical field of high polymer materials, biological medicines and nano materials, in particular to a preparation method and application of a novel fluorescent nano material with photodynamic therapy and sterilization functions. The preparation method comprises the following steps: dissolving an aniline compound and amino acid with deionized water, adding concentrated sulfuric acid after dissolving, and uniformly stirring and mixing; and transferring the uniformly mixed solution to a polytetrafluoroethylene reaction kettle, and carrying out hydrothermal reaction to obtain the novel macromolecular fluorescent nano material with the spiral structure. The fluorescent nano material can immediately generate hydroxyl free radicals, singlet oxygen and superoxide anion radical free radicals after being illuminated by ultraviolet light, visible light, laser and the like, and has extremely strong oxidation characteristics; when free radicals are generated, body color and fluorescence are changed, the generation of the free radicals can be judged according to the body color and fluorescence characteristics, and according to the characteristics of the photosensitizer, the photosensitizer can be applied to the fields of photodynamic therapy, photodynamic bacteriostasis and the like.

Description

technical field [0001] The invention relates to the technical fields of polymer materials, biomedicine and nanometer materials, in particular to a preparation method and application of a novel fluorescent nanometer material with photodynamic therapy and bactericidal functions. Background technique [0002] Nanotechnology refers to the design and synthesis of nanomaterials in the range of 1-100nm for functional materials, sensors and devices, etc. In this scale range, nanomaterials usually have large specific surface area, high chemical reactivity and easy absorption by organisms. Fluorescent nanomaterials mainly include carbon nanodots and carbon nanotubes. Because of their low biotoxicity, good biocompatibility, small size, and unique fluorescent properties, they are widely used in disease diagnosis, drug delivery, and biological It has been widely used in the fields of therapy, in vivo imaging, tumor targeting and so on. At present, there are few nanomaterials with photo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00C01B32/15A61K41/00A61P35/00A61L2/08
CPCC09K11/65B82Y20/00B82Y40/00C01B32/15A61K41/0057A61P35/00A61L2/088Y02A50/30
Inventor 雷炳富寇尔丰李唯张浩然张学杰潘晓琴梁嘉容郑明涛刘应亮
Owner SOUTH CHINA AGRI UNIV
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