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Quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics

An illegal addition and anti-dandruff technology, applied in the field of measurement, can solve the problems of cumbersome operation and unfavorable on-site inspection, and achieve the effects of low analysis cost, reliable inspection results, and easy operation

Active Publication Date: 2010-06-30
广东省汕头市药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The "Hygienic Standards for Cosmetics" (2007 edition) issued by the Ministry of Health has recorded the method of using high performance liquid chromatography to detect ketoconazole in anti-dandruff agents, but this method requires special instruments and equipment, and the operation is cumbersome, which is not conducive to on-site detection

Method used

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  • Quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics
  • Quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics
  • Quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0056] Sample to be inspected: No. HZ080017 Head & Shoulders New life anti-dandruff shampoo (refreshing cold type).

[0057] Detection method: Take 1.5g of the above sample crystal, add it to 4ml ethyl acetate, shake it gently for 1min, and let it stand for 3min; draw about 2ml of the upper liquid, inject it into 1ml of 5% dilute hydrochloric acid, and turn it upside down 3 times Mix it thoroughly and let it stand for 2 minutes; suck about 0.8 ml of the lower layer liquid, filter, and drop 3 drops of a saturated aqueous solution of trinitrophenol into the filtrate without precipitation.

[0058] At the same time, the above samples were tested according to the high performance liquid chromatography described in the "Hygiene Standards for Cosmetics" (2007 edition), and the results showed that the samples did not contain ketoconazole.

example 2

[0060] Samples to be inspected: No. HZ080048 Aoxue Chinese medicine nourishing hair shampoo (Saponaria saponaria antidandruff essence)

[0061] Detection method: Take 1.5g of the above sample, add it to 4ml of ethyl acetate, shake it gently for 1min, and let it stand for 3min; absorb about 2ml of the upper liquid, inject it into 1ml of 5% dilute hydrochloric acid, turn it upside down 3 times to make Mix it thoroughly and let it stand for 2 minutes; absorb about 0.8 ml of the lower layer of liquid, filter, and drop 3 drops of a saturated aqueous solution of trinitrophenol into the filtrate without precipitation.

[0062] At the same time, the above samples were tested according to the high performance liquid chromatography described in the "Hygiene Standards for Cosmetics" (2007 edition), and the results showed that the samples did not contain ketoconazole.

example 3

[0064] Sample to be inspected: No. HZ080015 Bawang Saponaria dandruff natural plant shampoo.

[0065] Detection method: Take 1.5g of the above sample, add it to 4ml of ethyl acetate, shake it gently for 1min, and let it stand for 3min; absorb about 2ml of the upper liquid, inject it into 1ml of 5% dilute hydrochloric acid, turn it upside down 3 times to make Mix it thoroughly and let it stand for 2 minutes; absorb about 0.8 ml of the lower layer of liquid, filter, and drop 3 drops of a saturated aqueous solution of trinitrophenol into the filtrate without precipitation.

[0066] At the same time, the above samples were tested according to the high performance liquid chromatography described in the "Hygiene Standards for Cosmetics" (2007 edition), and the results showed that the samples did not contain ketoconazole.

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Abstract

The invention provides a quick screening method for illegally-added ketoconazole in scurf removing shampoo cosmetics. The steps of the method are as follows: first, according to the characteristic that the ketoconazole is soluble to both organic solvent and inorganic acid solution, components possibly containing the ketoconazole are extracted by ethyl acetate from a shampoo product and are then extracted by the inorganic acid solution to dissolve the ketoconazole in the inorganic acid solution so as to further separate the ketoconazole from other interfering substances; second, according to the characteristic that the ketoconazole can react with an alkaloid precipitator to generate precipitation, saturated water solution of trinitrophenol is dripped into the inorganic acid solution possibly dissolved with the ketoconazole; the ketoconazole is possibly contained in a detected sample if the precipitation is generated, and vice versa. With high sensitivity, good accuracy, simple as well as easy operation, strong specificity, reliable detecting result and low analyzing cost, the quick screening method does not need a special instrument and is particularly suitable for quickly screening the illegally-added ketoconazole in the cosmetics on the scene.

Description

Technical field [0001] The invention relates to the field of measurement, in particular to qualitative detection using the chemical and physical properties of substances. Background technique [0002] Ketoconazole, whose chemical structure is shown in formula 1, is easily soluble in chloroform, slightly soluble in ethanol, and almost insoluble in water. It is an antifungal drug and is clinically used to treat epidermal and deep mycoses, including Skin and nail ringworm (for those who do not respond to local treatment), gastrointestinal yeast infections, vaginal candidiasis where topical medication is ineffective, and systemic infections caused by Candida albicans, coccidioidomyces, and histoplasma. [0003] [0004] Since ketoconazole has a certain antifungal effect, adding it to shampoo cosmetics can achieve a better anti-dandruff effect. However, long-term use of shampoos with ketoconazole can cause erythema, pimples, and burning on the skin. Burning sensation, dizziness and oth...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 于晓黄诺嘉黄奕滨罗丽娟
Owner 广东省汕头市药品检验所
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