The invention belongs to the technical field of cosmetics, and in particular relates to an anti-wrinkle face cream and a preparation method thereof. The anti-wrinkle face cream comprises butanediol, ethylhexyl palmitate, caprylic / capric triglyceride, glycerol, polyglycerol-10, ethylhexyl isononanoate, polymethyl methacrylate, polydimethylsiloxane, ceteareth-21, cetostearyl alcohol, ceteareth-2, acrylic acid (ester) type / acrylamide copolymer, betaine, avocado fruit butter, a lactic acid bacillus / balausta fermentation product extract, an arctic rock chlamydomonas essence, a starfish essence, a ginseng extract, a lucid ganoderma extract, an apple extract, tocopheryl acetate and the like. The anti-wrinkle face cream provided by the invention is good in penetrability and easy to absorb, can effectively replenish water and preserve moisture, and can repair skin wrinkles and inhibit generation of the winkles, thereby delaying skin aging.