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Artificial antigen presenting cells and methods of use thereof

InactiveUS20020131960A1Palliating their conditionReduce riskBiocideCompound screeningEpitopeAccessory molecule

The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. Methods of use for activation of T lymphocytes are also provided.

Artificial antigen presenting cells and methods of use thereof

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Owner:MEMORIAL SLOAN KETTERING CANCER CENT

Immunoglobulin variants and uses thereof

InactiveUS20100098730A1Preventing occurrencePrevent recurrenceImmunoglobulins against growth factorsAntibody ingredientsHalf-lifeIn vivo

Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.

Immunoglobulin variants and uses thereof

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Owner:F HOFFMANN LA ROCHE & CO AG

Conductive connecting pin and package substrate

InactiveUS20090053459A1Relaxing stress concentrationAvoid breakingPrinted circuit assemblingInsulating substrate metal adhesion improvementElectrical conductorElectrical connection

A package substrate 310 incorporating a substrate provided with a conductor layer 5, a conductive connecting pin 100 arranged to establish the electrical connection with a mother board and secured to the surface of the substrate, wherein a pad 16 for securing the conductive connecting pin is provided for the package substrate 310. The pad 16 is covered with an organic resin insulating layer 15 having an opening 18 through which the pad 16 is partially exposed to the outside. The conductive connecting pin 100 is secured to the pad exposed to the outside through the opening with a conductive adhesive agent 17 so that solution of the conductive connecting pin 100 from the substrate occurring, for example when mounting is performed is prevented.

Conductive connecting pin and package substrate

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Owner:IBIDEN CO LTD

Light-emitting device, production method therefor, and device using light-emitting device

ActiveUS20160027973A1Improve adhesionAvoid breakingSolid-state devicesSemiconductor/solid-state device manufacturingElastomerEngineering

Light-emitting device, production method therefor, and device using light-emitting device

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Owner:NICHIA CORP

Sheet feeding device with two cams

InactiveUS7270323B2Complex structureIncrease production costElectrographic process apparatusArticle separationCamSheet material

A sheet supplying / feeding device includes a sheet placing plate that receives at least a tip of a sheet, a feeding unit that feeds the sheet while being in contact with the sheet placed on the sheet placing plate, and a driving unit that drives the feeding unit. Preferably, cam members are provided at both ends of a rotating shaft of the feeding unit, displacement changing members are swingably provided in engagement with the cam members, the sheet placing plate is shifted synchronously with the swing of the displacement changing members through first elastic members, and the sheet placed on the sheet placing plate and the feeding unit are contacted and separated by the synchronous movement of the sheet placing plate and the displacement changing members.

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Owner:FUJIFILM BUSINESS INNOVATION CORP

Memory device employing magnetic domain wall movement

ActiveUS20080068880A1Increase heightSimple processSolid-state devicesRecording/reproducing/erasing methodsEngineeringMagnetic domain

Provided is a memory device employing magnetic domain wall movement. The memory device includes a writing track and a column structure. The writing track forms magnetic domains that have predetermined magnetization directions. The column structure is formed on the writing track and includes at least one interconnecting layer and at least one storage track.

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Owner:SAMSUNG ELECTRONICS CO LTD

Oxygen ion conducting ceramic material and use thereof

ActiveUS20050006249A1Improve oxidation efficiencyPreventing occurrencePhotography auxillary processesIsotope separationPartial oxidationChemical reactor

It is an object of the present invention to provide a ceramic member with excellent balance between oxygen ion conductivity and endurance (resistance to cracking and the like), an oxygen ion permeation module and a chemical reactor such as an oxygen separator, using such a ceramic member. The ceramic member with oxygen ion conductivity in accordance with the present invention has a perovskite-type crystal structure and a composition represented by the general formula (Ln_1-xM_x)(Ti_1-yFe_y)O₃(where Ln represents at least one element selected from lanthanoids, and M represents at least one element selected from the group containing Sr, Ca, and Ba, 0<x<1, 0.4≦y<1, x+y≧1). The oxygen ion permeation module composed by employing such a ceramic member can be used as a structural component of an oxygen separator, an oxidation reactor (for example, a reactor for partial oxidation of hydrocarbons), and the like.

Oxygen ion conducting ceramic material and use thereof

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Owner:NORITAKE CO LTD

Secure fluids transfer system for medical use

InactiveUS9149622B2Prevent leakagePreventing occurrenceCatheterTube connectorsTransfer systemEngineering

A fluid transfer system includes a Luer female connector having a main body containing an internal channel for passage of fluids and a collar surrounding at least a part of the end of the main body, and a Luer male connector having a main body with a longitudinal internal opening. The main body of the female connector contains a first threading on at least a part of the external surface of that portion that is surrounded by the collar, located at least in part facing an internal surface of the collar; one of the ends of the main body of the Luer male connector contains a second threading on at least a part of its internal surface delineating the longitudinal internal opening, which engages into and fits in the first threading to ensure joining between the Luer male and female connectors.

Secure fluids transfer system for medical use

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Owner:TECHNOFLEX SA

Assembly system that assembles insulating plate and mounting bar, and assembly method

ActiveUS20180159150A1Preventing quality deteriorationPreventing occurrenceHybrid vehiclesCharging stationsMechanical engineeringAssembly systems

An assembly system that assembles insulation plates and mounting bars to a stack may include a stack transferring device that discharges a stack pressed by a stack pressing device to the outside; an insulation plate attaching device that attaches insulation plates to a first opposite side and a second opposite side of the stack that is discharged to the outside by the stack transferring device; a mounting bar attaching device that attaches mounting bars to the stack to which the insulation plates are attached; and a bolt assembling device that assembles bolts to the mounting bars that are attached to the stack.

Assembly system that assembles insulating plate and mounting bar, and assembly method

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Owner:HYUNDAI MOTOR CO LTD +1

X-ray opaque filament, x-ray opaque covered filament and fiber structure using said x-ray opaque filament and/or x-ray opaque covered filament

InactiveUS20090302241A1Quality improvementLarge shrinkageSurgeryShieldingSoft x rayX-ray

An X-ray opaque filament is provided, which is constituted of a filament formed of a thermoplastic resin containing an X-ray opaque agent and has a dry heat shrinkage of 3.5 to 0% at 130° C. An X-ray opaque covered filament is provided, which is formed by covering the periphery of the X-ray opaque filament with a covering fiber. Furthermore, an X-ray opaque filament is provided, which is constituted of a fiber formed of a thermoplastic resin containing an X-ray opaque agent and has an oil containing an ionic surfactant in a ratio of 0 to 10% by mass added thereto. An X-ray opaque covered filament is provided, which has a covering fiber formed of a thermoplastic resin having a lower melting point than the thermoplastic resin constituting the X-ray opaque filament. A fiber structure is provided which includes the X-ray opaque filament and/or the X-ray opaque covered filament.

X-ray opaque filament, x-ray opaque covered filament and fiber structure using said x-ray opaque filament and/or x-ray opaque covered filament

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Owner:UNITIKA LTD

Conductive connecting pin and package substrate

InactiveUS20090154131A1Avoid separationIncrease the areaPrinted circuit assemblingInsulating substrate metal adhesion improvementElectrical conductorElectrical connection

A package substrate 310 incorporating a substrate provided with a conductor layer 5, a conductive connecting pin 100 arranged to establish the electrical connection with a mother board and secured to the surface of the substrate, wherein a pad 16 for securing the conductive connecting pin is provided for the package substrate 310. The pad 16 is covered with an organic resin insulating layer 15 having an opening 18 through which the pad 16 is partially exposed to the outside. The conductive connecting pin 100 is secured to the pad exposed to the outside through the opening with a conductive adhesive agent 17 so that solution of the conductive connecting pin 100 from the substrate occurring, for example when mounting is performed is prevented.

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Owner:IBIDEN CO LTD

Secure fluids transfer system for medical use

InactiveUS20130245611A1Simple designSimple in useCatheterTube connectorsTransfer systemEngineering

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Owner:TECHNOFLEX SA

Tr1 cells, mesenchymal stem cells and uses thereof

InactiveUS20100247577A1Promote tissue regenerationPromote angiogenesisBiocideNervous disorderDiseaseAutoimmune responses

The present invention relates to compositions comprising Tr1 cells and mesenchymal stem cells and methods for treating an autoimmune disease, an allergic disease or an inflammatory disease.

Tr1 cells, mesenchymal stem cells and uses thereof

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Owner:TXCELL

Gate valve for vacuum and seal member used therefor

ActiveUS8074967B2Inhibit the production of particlesParticles can be suppressedEngine sealsSlide valveStress concentrationEngineering

A gate valve for vacuum capable of preventing a seal member from being cracked or particles from being produced due to a stress concentration even if the seal member is repeatedly compressed in the state that the adhesive agent is separated from the open side of a seal member mounting groove and capable of suppressing particles from being produced due to the rub of the seal top part with the seal surface.

Gate valve for vacuum and seal member used therefor

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Owner:VALQUA LTD

METHODS OF MODULATING PROTEIN HOMEOSTASIS, METABOLIC SYNDROME, HEAVY METAL INTOXICATION AND Nrf2 TRANSCRIPTION FACTORS

InactiveUS20100086531A1Reduce and eliminate conditionPrevent degradationBiocidePeptide/protein ingredientsDiseaseAdjuvant therapy

Phthalazinediones that function as intracellular redox modulators in the redox therapy of certain stressed cells are provided. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments. The phthalazinediones of the invention can modulate functions related to cell growth, differentiation, activity, or death, to correct aberrations and restore homeostasis, and can serve as adjunctive therapy in treating various disease conditions.

Owner:BACH PHARMA

Pedal module

ActiveUS20050183535A1Preventing of of feelingPreventing occurrenceControlling membersLimiting/preventing/returning movement of partsCoil springEngineering

A pedal module includes a double coil spring, a pedal, and a damping part. The double coil spring includes an outside coil and an inside coil. The pedal turns in a forward direction when a depressing force is applied thereto and turns in a reverse direction when a restoring force of the double coil spring is applied thereto. The damping part has an inserting portion disposed between the outside coil and the inside coil. The inserting portion includes a middle portion and a first side end portion disposed relative to each other in a width direction that corresponds to a circumferential direction of the double coil spring. The middle portion crosses a radial axis of the double coil spring and protrudes beyond the first side end portion toward an axial end of the double coil spring.

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Owner:DENSO CORP

ST 188L as the prevention and treatment for cancers and infections

InactiveUS6586016B1Decrease it lak activityDemonstrate efficaciousBiocideUnknown materialsDose dependenceNatural Killer Cell Inhibitory Receptors

The present invention provides Chinese herbal compositions, ST 188L and method for prevention and treatment of cancers and infectious diseases. The Chinese herbal compositions comprise a formulation prepared ratably from a group of herbal plants consisting essentially of Ecchinops grijissii, Cirsium segetum Bge, Solanum indicum Linn, Lonicerae flos, and Zizyphi fructus. ST188L appeared to be activated in vivo to stimulate the activity of NK cells and LAK cells as shown by the increases in cytolytic activity of peripheral blood mononuclear cells isolated from volunteers after intake of ST 188L toward target cells, such as K562, Daudi, HepG2 and HBV transfected HepG2-2215 in a dose dependent manner. ST 188L has been proven to be effective on eradicating malignancy in a cancer patient by enhancing said patients' endogenous immune system to keep said patient cancer free for more than ten years.

ST 188L as the prevention and treatment for cancers and infections

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Owner:SAGITTARIUS LIFE SCI

Light-emitting device with improved flexural resistance and electrical connection between layers, production method therefor, and device using light-emitting device

ActiveUS9837587B2Excellent characteristicsIncrease resistanceSolid-state devicesGlass/slag layered productsElectricityElastomer

A light-emitting device includes a pair of light-transmissive insulator sheets disposed opposite to each other and two types of light-transmissive electroconductive layers disposed on a common one of or separately on one and the other of the pair of light-transmissive insulator sheets, and at least one light-emitting semiconductor each provided with a cathode and an anode which are individually and electrically connected to the two types of the light-transmissive electroconductive layers. The electrical connection and mechanical bonding between the members are improved by a light-transmissive elastomer which is between the pair of light-transmissive insulator sheets. A method in which a light-emitting semiconductor element and a light-transmissive electroconductive member are subjected to vacuum hot-pressing.

Light-emitting device with improved flexural resistance and electrical connection between layers, production method therefor, and device using light-emitting device

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Owner:NICHIA CORP

Exhaust gas control apparatus for internal combustion engine

ActiveUS20150128572A1Prevent decrease in purification ability of purificationQuickly reach activation temperatureElectrical controlInternal combustion piston enginesExhaust gasEngineering

An exhaust gas control apparatus for an internal combustion engine, controls an exhaust operation of the internal combustion engine (200) provided with an exhaust gas purification catalyst (216) in an exhaust passage (215). The exhaust gas control apparatus for the internal combustion engine is provided with a warming-up device configured to warm up the exhaust gas purification catalyst; and an oxygen supplying device (220, 221) configured to supply oxygen to the exhaust gas purification catalyst after the end of the warm-up. This makes it possible to preferably desorb sulfur adsorbed to the exhaust gas purification catalyst during warm-up. It is therefore possible to suppress a reduction in purification ability of the exhaust gas purification catalyst due to sulfur coating.

Exhaust gas control apparatus for internal combustion engine

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Owner:TOYOTA JIDOSHA KK

Engine mount having bracket coupling hook

ActiveUS20190072151A1Reduce weightEnsure durabilitySpringsVehicle design optimisationPlastic materialsCoupling

An engine mount for a vehicle includes: a core which is made of a plastic material and attached to an outer circumferential surface at a lower end of a main rubber body; and a cover which is coupled to the core to close a lower opening of a bracket, in which the core and the bracket are assembled by coupling the core and the cover and then inserting a hook formed on the core into a groove formed in an inner wall surface of a body of the bracket.

Engine mount having bracket coupling hook

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Owner:HYUNDAI MOTOR CO LTD +1

Method of producing a composite sheet and method of producing a laminate by using the composite sheet

InactiveUS7018494B2Defective connectionAvoid connectionSemiconductor/solid-state device detailsSolid-state devicesMetallurgyMetal sheet

A method of producing a composite sheet in which a through hole formed in a predetermined portion of the first ceramic sheet is buried with a different kind of sheet having substantially the same thickness as the first ceramic sheet, such as a resin sheet a metal sheet or a ceramic sheet of a material different from that of the first ceramic sheet. A first method comprises a step of preparing a first ceramic sheet from a ceramic powder, and a different kind of sheet; a step of forming a through hole in a predetermined portion of the first ceramic sheet; a step of laminating the different kind of sheet on the ceramic sheet in which the through hole is formed; and a step of preparing a composite sheet by pressing the portion of the first ceramic sheet where the through hole is formed from the side of the different kind of sheet, such that the first ceramic sheet and the different kind of sheet are integrated together. A second method comprises a step of preparing a first ceramic sheet and a different kind of sheet, and laminating the first ceramic sheet and the different kind of sheet one upon the other; and a step of preparing a composite sheet by pressing a predetermined portion of the laminate from the side of the different kind of sheet, such that the pressed portion of the different kind of sheet is transferred onto the side of the first ceramic sheet to integrate the first ceramic sheet and the different kind of sheet together. A further method is for producing a laminate by laminating the obtained composite sheet on other first ceramic sheet or on other composite sheet.

Method of producing a composite sheet and method of producing a laminate by using the composite sheet

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Owner:KYOCERA CORP

Memory device employing magnetic domain wall movement

ActiveUS8115238B2High density data recording capabilityStable structureSolid-state devicesRecording/reproducing/erasing methodsEngineeringMagnetic domain

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Owner:SAMSUNG ELECTRONICS CO LTD

Thermal development method and apparatus

InactiveUS20050058954A1Avoid it happening againPreventing of in densityRecording apparatusX-ray/infra-red processesLatent imageImage formation

In a thermal development method for generating a image from a latent image recorded on an image formation layer of a photosensitive photothermographic recording material, by means of heating the photosensitive photothermographic recording material, a first surface, which is one surface of the photosensitive photothermographic recording material A, and a second surface, which is the remaining surface of the same, are heated; and a total amount of heat applied to the second surface is controlled so as to fall within a range of 100±30 when a total amount of heat applied to the first surface is taken as 100 in connection with the respective total amounts of heat which are applied to the image formation layer from the first and second surfaces and equal to and higher than the development reaction temperature.

Thermal development method and apparatus

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Owner:FUJIFILM HLDG CORP +1

Dental Appliance Cleanser

InactiveUS20110220154A1Avoid it happening againReduce morbidityCosmetic preparationsToilet preparationsChlorhexidineCleansers skin

This disclosure relates to a persulfate-free dental appliance cleanser containing a low-concentration of chlorhexidine, or a pharmaceutically acceptable salt thereof.

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Owner:GLAXO SMITHKLINE LLC

Method for forming conductor pattern, wiring board, and liquid droplet ejecting apapratus

InactiveUS20110169884A1Improve reliabilityEasy to useInksConductive pattern formationElectrical conductorEngineering

A method for forming a conductor pattern includes: forming a conductor pattern precursor by ejecting liquid droplets of a conductor pattern forming ink by a liquid droplet ejecting method onto a substrate, and drying the liquid droplets, thereby forming a conductor pattern precursor having a pad part and a wiring part connected to the pad part on the substrate; and firing the precursor, thereby forming the conductor pattern, wherein in the formation of the conductor pattern precursor, the liquid droplets of the conductor pattern forming ink are ejected in such a manner that positions where the liquid droplets of the conductor pattern forming ink are attached form plural concentric annular shapes within a pad forming region where the pad part is to be formed on the substrate.