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Prescription and preparation method of compound ornidazole suppository for treating vaginitis

A technology of compound ornidazole suppositories and vaginitis, applied in the field of gynecological medical care, to achieve the effect of good reproducibility, sensitive content of main components, and easy to master

Inactive Publication Date: 2016-06-15
李达
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of compound tinidazole suppositories, tinidazole suppository vaginal effervescent tablets and other topical medications has been reported, but it has not been reported that ornidazole combined with broad-spectrum antifungal drug clotrimazole to make compound ornidazole suppositories

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A prescription for the compound ornidazole suppository for the treatment of vaginitis, made according to the following parts by weight;

[0020] 20g parts of ornidazole, 15 parts g of clotrimazole, 365 parts of glycerin gelatin.

[0021] Its preparation method is to take ornidazole and clotrimazole and grind them finely with glycerin gelatin, then add them into the heated and melted glycerin gelatin matrix, pour them into suppository molds while hot, and sequentially go through solidification, scraping, and packaging processes. Nitazole suppository products.

[0022] Wherein, the preparation method of glycerin gelatin matrix is ​​as follows:

[0023] Take 500g of gelatin and immerse it in an appropriate amount of purified water, soften it and move it to a beaker of known weight, add 500g of glycerin, heat until the gelatin dissolves, remove excess water by evaporation, reduce the weight to 1030g, and obtain glycerin gelatin through filtration and condensation processes...

Embodiment 2

[0028] A prescription for the compound ornidazole suppository for the treatment of vaginitis, made according to the following parts by weight;

[0029] 25g parts of ornidazole, 17 parts g of clotrimazole, 370 parts of glycerin gelatin.

[0030] Its preparation method is to take ornidazole and clotrimazole and grind them finely with glycerin gelatin, then add them into the heated and melted glycerin gelatin matrix, pour them into suppository molds while hot, and sequentially go through solidification, scraping, and packaging processes. Nitazole suppository products.

[0031] Wherein, the preparation method of glycerin gelatin matrix is ​​as follows:

[0032] Take 550g of gelatin and immerse in an appropriate amount of purified water, soften it and move it to a beaker of known weight, add 550g of glycerin, heat until the gelatin dissolves, remove excess water by evaporation, reduce the weight to 1040g, and obtain glycerin gelatin through filtration and condensation processes. ...

Embodiment 3

[0037] A prescription for the compound ornidazole suppository for the treatment of vaginitis, made according to the following parts by weight;

[0038] 30 g parts of ornidazole, 20 parts g of clotrimazole, 375 parts of glycerin gelatin.

[0039] Its preparation method is to take ornidazole and clotrimazole and grind them finely with glycerin gelatin, then add them into the heated and melted glycerin gelatin matrix, pour them into suppository molds while hot, and sequentially go through solidification, scraping, and packaging processes. Nitazole suppository products.

[0040] Wherein, the preparation method of glycerin gelatin matrix is ​​as follows:

[0041] Take 600g of gelatin and immerse in an appropriate amount of purified water, soften it and move it to a beaker of known weight, add 600g of glycerin, heat until the gelatin dissolves, remove excess water by evaporation, reduce the weight to 1050g, and obtain glycerin gelatin through filtration and condensation processes. ...

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PUM

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Abstract

The invention relates to technical field of gynecology medical treatment, in particular to a prescription and preparation method of a compound ornidazole suppository for treating vaginitis.The compound ornidazole suppository is prepared by, by weight, 20-30 parts of ornidazole, 15-20 parts of clotrimazole and 365-375 parts of glycerin gelatin.The preparation method includes: evenly grinding the ornidazole, the clotrimazole and the glycerin gelatin, then adding into glycerin gelatin matrix melt by heat, pouring into a suppository die while the mixture is hot, and solidifying, smoothing and packaging to obtain the compound ornidazole suppository.The preparation method has the advantages that the influence of the matrix on content measuring can be eliminated, complete medicine extraction is achieved, the content measuring of the ornidazole and the clotrimazole is unaffected, and the absorbance of the ornidazole and the clotrimazole in a certain time is constant.The compound ornidazole suppository is simple in preparation process and stable in curative effect.The compound ornidazole suppository is sensitive and accurate, good in repeatability and easy to master when high performance liquid chromatography is used for measuring main components.

Description

technical field [0001] The invention relates to the technical field of gynecological medical care, in particular to a formula and a preparation method of a compound ornidazole suppository for treating vaginitis. Background technique [0002] Vaginitis is inflammation of the vagina. Due to the characteristics of anatomical tissue, the vagina of normal healthy women has a natural defense function against the invasion of pathogens. For example, the closure of the vaginal opening, the close contact of the front and rear walls of the vagina, the hyperplasia of vaginal epithelial cells and keratinization of surface cells under the influence of estrogen, and the balance of vaginal pH balance inhibits the reproduction of pathogens that adapt to alkaline, while the cervical mucus appears Alkaline, when the natural defense function of the vagina is destroyed, pathogens are easy to invade, leading to vaginal inflammation. [0003] Ornidazole is an anti-anaerobic and antiprotozoal dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K9/02A61K47/42A61K47/10A61P15/02A61K31/4164
CPCA61K9/025A61K31/4164A61K31/4174A61K47/10A61K47/42A61K2300/00
Inventor 李娜柳燕于英英隋光丽陈丽媛王芳尹喜玲韩景奇
Owner 李达
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