54 results about "Econazole Nitrate" patented technology

The invention discloses a triamcinolone acetonide and econazole nitrate cream which contains econazole nitrate and triamcinolone acetonide. The invention is characterized in that the cream also contains octodecyl alcohol or hexadecanol. The triamcinolone acetonide and econazole nitrate cream is more subtle and even, is easy to be daubed and washed on and away from the skin and is harmless to skin, has no odor. No greasiness is to be felt when the cream is daubed on the skin, and the quality is more stable.

The nanometer antifungal econazole nitrate emulsion medicine consists of econazole nitrate, surfactant, oil and distilled water. Its preparation process includes the following steps: weighing the materials; mixing the surfactant and oil and dissolving econazole nitrate in dimethyl sulphoxide; mixing the solution of econazole nitrate with the surfactant and oil; and final adding distilled water slowly while stirring to form stable homogeneous transparent nanometer antifungal econazole nitrate emulsion medicine. The medicine is used in treating candidal tinea corporis, tinea cruris and tinea pedis, aural mycosis, seborrheic dermatitis, etc. The medicine is absorbed through skin to enter into blood circulation, and this avoids the first pass effect of liver, prolongs the medicine release and prevents stimulation to gastrointestinal tract. The preparation process is simple and low in power consumption.

The invention discloses a compound dimetridazole premix for preventing and treating the poultry enterovirus syndrome. The premix is prepared by uniformly mixing the following components in percentage by weight: 10 to 30 percent of dimetridazole, 4 to 10 percent of neomycin sulfate, 2 to 8 percent of decoquinate econazole nitrate, 10 to 30 percent of lysozyme, 0.5 to 5 percent of etamsylate, 3 to 10 percent of lactic acid TMP and the balance of pharmaceutically applicable auxiliary material. According to the invention, the novel high-efficiency anticoccidial drug decoquinate econazole nitrate, the dimetridazole and the neomycin sulfate which have a special curative effect on intestinal infection, the lysozyme with effects of resisting to bacteria, resisting to viruses, diminishing inflammation, relieving pain and repairing intestinal mucosa, the high-efficiency hemostatics etamsylate and the drug synergist are compounded into a compound preparation; and the compound dimetridazole premix has a high-efficiency treatment effect on the poultry enterovirus syndrome. The compound dimetridazole premix has a reasonable and scientific formula, is simple to prepare, has wide application and can be used as a priority drug for preventing and treating the poultry enterovirus syndrome.

A compound zedoary oil ointment for treating vaginitis, tinear manuum, tinear pedis, ringworm of body and skin infection is prepared through mixing zedoary oil, monoglyceride stearate, stearic acid and vaseline, heating, filtering to obtain liquid, adding econazole nitrate, borneol, sodium laurylsulfate and hydroxyethylester to the mixture of glycerine and water, heating, filtering to obtain liquid, mixing two kinds of liquid together and stirring.

The invention relates to an econazole nitrate microemulsion aerosol and a method for preparing the same. The aerosol is prepared by the materials mainly comprising econazole nitrate, polyethylene glycol 400, polysorbate 80, octane pheno1 polyoxyethylene 10, imidazoline, sodium lauryl sulfate, coconutt diethanol amide, sodium laureth sulfate, dioctyl sulfosuccinate sodium salt, polyoxyethylenated castor oil, purified water, and propane and butane. The method for preparing the aerosol comprises the following steps: dissolving the materials under different conditions; uniformly stirring the solution obtained after dissolution to obtain a primary emulsion; passing the primary emulsion first through a 0.80 mu m of filter membrane, then a nanomachine, and finally a 0.22 mu m of filter membrane; and filling, filling propane-butane projectile and sealing to obtain the finished product of econazole nitrate nanometer microemulsion aerosol.

A composite medicine for treating vaginitis is prepared from fossyol, econazole nitrate or miconazole nitrate, and medicinal auxiliary.

The invention relates to a compound aromatic turmeric oil gelling agent and its preparing process, wherein each 1000g of the preparation comprises econazole nitrate 12.5g, oil of aromatic turmeric 52.5ml, gel base material 1-30g. The constituents also include sodium hydroxide, propylene glycol, ethanol, polysorbate -80, sorbic acid, sodium metabisulfite, vitamin E and deionized water. The gel base material is the mixture of carbome, sodium carboxymethylcellulose and sodium alginate.

The invention relates to a compound aromatic turmeric oil emulsion type foam aerosol of Econazole nitrate and its preparing process, wherein each 1000mL of the aerosol contains the following constituents (by mass ratio): Econazole nitrate 1-100g, aromatic turmeric oil 1-200g, emulsifying agent 5-250g, preservative agent 0.1-20g, projection agent 50-500g, and balancing dissolvent. The aerosol can be used for treating vaginitis, cervical erosion and uterine neck disease.

The invention discloses external use emulsifiable paste for treating skin diseases and with econazole nitrate and triamcinolone acetonide as active components and a preparation method. The triamcinolone acetonide and econazole emulsifiable paste is prepared from, by weight, 10 parts of econazole nitrate, 1 part of triamcinolone acetonide, 3-10 parts of glycerin monostearate and glycerol distearate, 10-20 parts of stearic acid, 1-10 parts of albolene, 0.8-7 parts of light liquid paraffin, 8-17 parts of glycerinum, 1-10 parts of triethanolamine, 0.08-0.5 part of ethylparaben, 0.08-0.5 part of borax, 0.5-5 parts of dimethyl sulfoxide and 10-60 parts of distilled water. The preparation method includes the steps of oil phase preparation, water phase preparation and finished product preparation. The preparation method includes the steps of oil phase preparation, water phase preparation and finished product preparation. The paste has the advantages that by means of the optimized formula, stability of the preparation is improved, the problem that econazole nitrate and triamcinolone acetonide are difficult to dissolve is solved, and the complex skin diseases caused by fungus and bacterial infection are effectively treated.

The invention discloses triamcinolone acetonide and miconazole emulsion type gel. The gel comprises econazole nitrate and triamcinolone with effective doses, as well as 1 to 9 weight percent of lipophilic phase and 90 to 98 weight percent of hydrophilic phase, wherein the lipophilic phase comprises a lipophilic compound and / or a lipophilic surfactant, and the hydrophilic phase comprises hydrophilic gel matrix, a hydrophilic compound and a hydrophilic surfactant. According to the triamcinolone acetonide and miconazole emulsion type gel prepared by the prescription disclosed by the invention, econazole nitrate and triamcinolone have good in stability and cannot be easily separated out, and the product has a good transparent appearance; due to the low content of lipophilic phase in the product, oily feeling does not exist after the gel is applied to skin; and the hydrophilic gel matrix is contained in the product, so that a transparent film can be formed after the gel is applied to skin, the texture is uniform and smooth, and the gel is easily applied, is not irritant and can be used for increasing the compliance of a patient.

The invention provides a water-soluble cyclodextrin derivative clathrate of econazole nitrate, a vaginal contraception thermosensitive gelata containing the clathrate and a preparation method of the gelata. According to the invention, water-indissoluble econazole nitrate is clathrated by a water-soluble cyclodextrin derivative to improve the solubility of econazole nitrate in water, so the vaginal thermosensitive gelata is prepared by treating econazole nitrate as a sperm killing active component for an external contraceptive, and the vaginal thermosensitive gelata which is a novel external contraception preparation comprises the water-soluble cyclodextrin derivative clathrate of econazole nitrate, a thermosensitive gel skeletal material and an acidic buffer. The contraception thermosensitive gelata which is a liquid when it is at the outside of a body can be rapidly and uniformly coated on vaginal surfaces, and becomes a semisolid gel when it is in the body to immobilizedly capture sperms until the sperms are killed. The contraception thermosensitive gelata of econazole nitrate has the advantages of use convenience, rapid action, reliability, and good safety. The gelata which is a novel dosage form and has the characteristics of easy preparation and low material cost is in favor of the family planning work in such a world's most populous country China.

The compound econazole nitrate film forming gel composition consists of hydroxyalkyl cellulose 0.5-7 wt%, esterifying agent 1-10 wt%, crosslink agent 0.5- 5 wt%, reinforcer 0-5 wt%, solvent 75-90 wt%, econazole nitrate 0.1-5 wt% and triamcinoline aceonide 0.01-3 wt%. The crosslink agent is saturated fatty polyol or alcohol acid in the general expression of CnH2n+2-m-l(OH)m(COOH)l, where, n, m, l are integrals, m is n-2, l is not smaller than 0, m+l is 4-8, and n+l is 4-8. The compound econazole nitrate film forming gel composition is used in treating local fungal inflammation through coating to surface of skin to form one smooth tough antiwear hydrophobic protecting film.

The invention relates to application of oxidized resveratrol and combined oxidized resveratrol and antibiotic in the preparation of an anti-fungal-infection product, belonging to the technical field of medicines. Oxidized resveratrol contains nautical components, is good in safety and has good antibacterial capacity to trichophyton rubrum and Candida albicans. When the oxidized resveratrol and an antibiotic, namely econazole nitrate jointly act on the two bacteria, the antibacterial effects on the two bacteria are superior to the antibacterial effects of dependent independent oxidized resveratrol and antibiotic on the two bacteria under the same use concentration, so that natural oxidized resveratrol is used for replacing partial econazole nitrate so as to inhibit fungi, the use amount of econazole nitrate can be reduced, and the research and development of novel, efficient and natural anti-fungal-infection drugs are benefited.

The invention relates to an econazole nitrate vaginal soft capsule and a preparation method thereof, wherein the econazole nitrate vaginal soft capsule comprises a soft capsule skin and contents filled in the soft capsule skin, wherein the contents are as follows: Parts by weight include: 50 parts of econazole nitrate, 250-350 parts of white vaseline, 25 parts of beeswax and 325-425 parts of light liquid paraffin; the soft capsule skin includes by weight parts: 1 part of gelatin, 0.6 1 part glycerin, 1 part water and 0.008 part opacifier. The econazole nitrate vaginal soft capsule of the present invention can be stored and transported at room temperature, which is convenient for patients to store the drug and ensure the quality and use of the drug, and the soft capsule skin contains a sunscreen, which effectively prevents econazole nitrate Econazole nitrate is stable due to product changes due to exposure to light during storage and transportation.

The invention discloses a preparation method of econazole nitrate. The preparation method comprises the steps of with 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (imidazole ethanol for short) and p-chlorobenzyl chloride as raw materials, Ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmin]BF4) as a solvent and an in-phase reaction catalyst, tetrabutylammonium bromide (TBAB) as a phase transfer catalyst, isopropanol as a solvent and anhydrous potassium carbonate as a basic catalyst, carrying out O-alkylation reaction, acidification and recrystallization, so as to obtain econazole nitrate. The preparation method is simple and convenient in operation, mild in reaction conditions and high in yield, the purity of prepared econazole nitrate is higher than 99.9%, and the preparedeconazole nitrate has very high industrial application values.

The invention provides external use emulsifiable paste for treating skin diseases and with econazole nitrate as an active component and a preparation method. The emulsifiable paste is basically prepared from, by weight, 10 parts of econazole nitrate, 3-10 parts of glycerin monostearate and glycerol distearate, 10-20 parts of stearic acid, 1-10 parts of albolene, 0.8-7 parts of light liquid paraffin, 8-17 parts of glycerinum, 1-10 parts of triethanolamine, 0.08-0.5 part of borax and 15-75 parts of distilled water. The preparation method includes the steps of oil phase preparation, water phase preparation and finished product preparation. The emulsifiable paste has the advantages that through the synergetic action of all the components in the formula, the transcutaneous permeation function of the medicine components is improved, and the treatment effect is improved. The econazole nitrate emulsifiable paste is good in stability, and the phenomenon of layering or crystal separation does not happen. The granularity of the econazole nitrate emulsifiable paste prepared through the method is small, so that it is guaranteed that the preparation is finer, uniform in content and convenient to use, and coating and clearing of the preparation are easy.

Disclosed is a compound forming agent with zedoary turmeric oil and method for preparation, which consists of mixing oil of aromatic turmeric, Span-80, glycerin, Tween-80 and sodium dodecylsulfate, stirring homogeneously, mixing Xiaoyikangcuo with right amount of ethanol and dissolving, mixing the two obtained solutions, stirring homogeneously, charging distilled water and mixing homogeneously, making foams through a hand net type foam emulsion generation device.

The invention belongs to the technical field of medicine preparations, particularly relates to an econazole nitrate microemulsion and a preparation method and application thereof, and discloses the econazole nitrate microemulsion. The pharmaceutical composition is prepared from econazole nitrate, a surfactant and a cosurfactant; an oil phase is mixed at a certain ratio; the surfactant is Tween; the cosurfactant is absolute ethyl alcohol; and the oil phase is ethyl butyrate. The econazole nitrate microemulsion disclosed by the invention is simple in prescription, convenient to operate, simple in preparation technology, uniform in particle distribution, small in viscosity, transparent, good in stability and adsorbability, high in bioavailability, long in half-life period, small in side effect of the medicine effect, and controllable in quality; and the product is good in repeatability, and convenient to popularize and utilize.

The invention belongs to the field of external-use medicine, and provides a spray for treating cutaneous moniliasis. The spray is prepared from econazole nitrate, polysorbate-80, propylene glycol, ethanol, purified water and rose essence. The spray for treating the cutaneous moniliasis has the advantages that the stability of the econazole nitrate as a pharmaceutical active ingredient, as well asthe stability of the pharmaceutical preparation are improved through interaction of the components; the transdermal absorption is fast, and the antibacterial effect is good; the spray is convenient toprepare and use, and low in cost, thereby being an effective fungicide.

The invention belongs to the field of analytical chemistry and particularly relates to a method using an HPLC method to separate and measure related substances in composition of triamcinolone acetonide and econazole nitrate. The method is characterized in that a reversed phase liquid chromatography method is used; octadecyl silane bonded silica gel is used as the chromatographic column of filler, and mixed liquid of a diammonium hydrogen phosphate solution and an organic solvent is used as the flowing phase to perform elution and separation. The method has the advantages that the blank of the prior art is filled up, a high-performance liquid chromatography method is used to separate and measure the triamcinolone acetonide, the econazole nitrate and the related substances in the composition of the triamcinolone acetonide and the econazole nitrate, and auxiliary material peaks can be separated effectively so as to prevent the same from affecting the detecting of the related substances. The method is good in separation degree, high in specificity, high in sensitivity, simple to operate, simple, fast, capable of guaranteeing the safety and effectiveness of products and significant to the quality control of the composition of the triamcinolone acetonide and the econazole nitrate.

An econazole film for treating vaginitis is prepared from econazole, filming material and antioxidizing agent through immersing filming material in water dissolving it in water bath, dissolving econazole in methanol, mixing it with the aqueous solution of filming material, adding antioxidizing agent, stirring removing air bubbles, filming and drying.

The invention discloses a method for synthesizing econazole nitrate by using a one-pot method, and belongs to the technical field of synthesis methods of econazole nitrate. The method comprises: carrying out an N-alkylation reaction under the actions of K2CO3 / KOH / Al2O3 and PEG-200 by using 1-(2,4-dichlorophenyl)-2-chloro-ethanol and imidazole as raw materials to obtain toluene-containing imidazoleethanol; and carrying out an O-alkylation reaction on the toluene-containing imidazole ethanol and p-chlorobenzyl chloride under the actions of K2CO3 / KOH / Al2O3 and PEG-200 to obtain econazole nitrate. According to the method of the invention, the intermediate imidazole ethanol is directly subjected to the O-alkylation reaction without water washing to achieve nearly neutral state, re-crystallization and drying, so that the environmental pollution caused by drying is reduced, the imidazole ethanol dissolving process is shortened, the reaction efficiency is improved, and the solvent recovery frequency is reduced; and after the O-alkylation reaction is finished, the impurity removal is performed before the acidification, so that the high product viscosity caused by many impurities is greatlyreduced, the solid-liquid separation is easy to realize, the one-pot production is realized, the cost is low, the operation is simple and convenient, and the method is suitable for industrial popularization.

The invention discloses a compound zedoary-turmeric-oil foam agent and the preparation method. The invention is characterized in that econazole nitrate, zedoary-turmeric oil and so on which serve as raw material and excipient are poured together into a container, then a foam-emulsion pump (or called foam pump or manual foam-generating device) is covered in a twisted way to generate foam by manually pressing the emulsion pump. The preparation method includes the following steps: first take econazole nitrate and zedoary-turmeric oil to mix evenly with polysorbate-80; add propanediol, water of proper amount for dissolution; then add polysorbate-80, lauryl sodium sulfate, propanediol, glycerin and so on, and mix evenly; add distilled water to total amount and mix evenly to adjust pH value; pour into the container and cover with the foam-emulsion pump (or called foam pump or manual foam-generating device) in a twisted way. Then the foam can be generated by manually pressing the emulsion pump. Generating foam by using medicine, emulsifier and a foam-emulsion pump and by pressing the foam-emulsion pump manually can save the cost, eliminate the environmental pollution caused by adding propellant and reduce the explosion probability of pressure vessels, so that the foam-generating process is safer. The invention is a novel foam agent of simple preparation, low cost, security and environmental protection. The compound zedoary-turmeric-oil foam agent can have the medicine distributed evenly in the vaginal canal and the surface of the skin and coated extensively, so at to filter into the vagina mucosa plica rapidly and effectively. The invention which is a good medicine for treating gynecologic diseases has the advantages of sufficient and rapid exertion of the curative effect, good curative effect, safe, sanitary and convenient usage.

The invention relates to a daily product, in particular to a cleanser essence containing anti-allergy components. The cleanser essence is prepared from, by weight, 18-24 parts of an anionic surfactant, 11-16% of a nonionic surfactant, 0.02-0.03% of econazole nitrate, 0.002-0.003% of triamcinolone acetonide, 0.2-0.4% of polyoxyethylene olein, 0.2-0.4% of ethylenediaminetetraacetic acid disodium salt, 0.1-0.5% of vitamin E, 0.02-0.05% of butylated hydroxyanisole, 0.05-0.13% of citric acid, 0.05-0.5% of edible essence, 0.05-0.2% of carbon phthalein trichloroaniline and the balance deionized water. The cleanser essence contains anti-allergy components, and therefore the skin irritation of chemical components in the cleanser essence can be relieved.

The invention relates to the application of compound oil of zedoary turmeric bolt in manufacturing medicament to cure desquamation colpitis. Every ten thousand application units contain 1.05-6.30L oil of zedoary turmetric, 0.25-1.50KG nitric acid econazole, 0.015-0.09KG ice slabs, and the bolt agent includes tween-80, dimethyl sulphoxide, stearic acid poly hydrocarbon(40) ester, polyethylene glycol-1500, polyethylene glycol-6000, etc. The compound oil of zedoary turmetric bolt has the function of promoting flow of qi and blood circulation, clearing away the heat-evil and expelling superficial evils and enhancing organism immunizing ability; ice slabs could remove putrefaction, relieve inflammation, alleviate pain and promote wound surface cicatrizing. It has good effect in curing desquamation colpitis.

The invention relates to an econazole nitrate compound crystal. After the compound crystal is determined by using a powder X-ray diffraction determination method, an X-ray powder diffraction pattern which is expressed by a diffraction angle of 2theta plus or minus 0.2 degrees shows characteristic diffraction peaks at 10.1 degrees, 10.6 degrees, 14.8 degrees, 15.4 degrees, 16.9 degrees, 19.8 degrees, 20.4 degrees, 26.7 degrees, 29.8 degrees, 30.3 degrees and 33.4 degrees. The compound crystal is a novel crystal which is different from the econazole nitrate crystal in the prior art. According to a solubility test, the compound crystal has higher water solubility. Besides, the invention additionally provides a preparation method of the econazole nitrate compound crystal, drug composition containing the compound crystal and a preparation method of the drug composition.