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Use of compound Rhizoma-curcumae-zedoariae oil suppository preparing medicine for treating desquamating colpitis

A compound zedoary oil and zedoary oil technology, which can be used in drug combination, disease, suppository delivery, etc., can solve the problems of high price and large vaginal flora

Inactive Publication Date: 2006-08-09
SUNSTONE TANGSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For the treatment of DIV, aerobic bacteria such as Escherichia coli, Enterococcus faecalis, Corynebacterium, Staphylococcus aureus, Streptococcus hemolyticus, etc. are generally targeted. Ampicillin-amoxicillin, or penicillin plus clavulanic acid, sulbactam, etc. The above are systemic medications, which have a greater impact on vaginal flora than topical medications, and are more expensive (Sweet RL, Gibbs RS. 4thed, 2002: Lippincott Williams&Wilkins, Infectious Diseases of the Female Genital Tract, 1-12, 612-622.)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Application of compound curcuma oil suppository in preparation of medicine for treating desquamative vaginitis.

Embodiment 2

[0065] For the application of compound curcuma oil suppositories in the preparation of drugs for treating desquamative vaginitis, for every 10,000 application units, the curcuma oil can be 1.05-6.30L, the econazole nitrate can be 0.25-1.50KG, and the borneol can be 0.015 ~0.09KG;

[0066] The suppository composition also includes:

[0067] Tween-80 0.21~0.82KG

[0068] Dimethyl sulfoxide 0.2~0.8KG

[0069] Polyoxyl (40) stearate 6.65~19.94KG

[0070] Polyethylene glycol-1500 5.32~15.95KG

[0071] Polyethylene glycol-6000 1.33~3.99KG.

[0072] This suppository preparation method is:

[0073] Take borneol and add it to zedoary oil and Tween-80, and stir it evenly to obtain the medicinal solution (1); take econazole nitrate and add it to dimethyl sulfoxide, and stir it evenly to obtain the medicinal solution (2); Hydroxyl (40) ester, polyethylene glycol-1500, and polyethylene glycol-6000 are placed in a chemical material tank, melted and stirred in a water bath at 80°C to o...

Embodiment 3

[0075] Application of the compound curcuma oil suppository as in embodiment 2 in the preparation of the medicine for treating desquamative vaginitis, but the dosage form adopted is capsule suppository, and its composition also includes:

[0076] The composition of the excipients is:

[0077] Soybean oil 4.0~12KG

[0078] Vaseline 1.5~4.5KG

[0079] Dimethyl sulfoxide 0.2~0.6KG

[0080] Paraben ethyl ester 0.01~0.03KG

[0081] The composition of the shell liquid is:

[0082] Gelatin 1.90~5.70KG

[0083]Glycerin 0.83~2.48KG

[0084] Water 1.70~5.1KG

[0085] Lemon yellow 0.01~0.03KG

[0086] Medicinal titanium dioxide 0.2~0.6KG.

[0087] The preparation method of capsule suppository is:

[0088] 1. Preparation of liquid medicine:

[0089] (1) Weigh the prescribed amount of soybean oil and medicinal vaseline, heat it in a water bath to 40°C, add ethylparaben, and stir to dissolve it.

[0090] (2) Weigh the borneol and add it to the zedoary oil, stir to dissolve it.

...

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PUM

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Abstract

The invention relates to the application of compound oil of zedoary turmeric bolt in manufacturing medicament to cure desquamation colpitis. Every ten thousand application units contain 1.05-6.30L oil of zedoary turmetric, 0.25-1.50KG nitric acid econazole, 0.015-0.09KG ice slabs, and the bolt agent includes tween-80, dimethyl sulphoxide, stearic acid poly hydrocarbon(40) ester, polyethylene glycol-1500, polyethylene glycol-6000, etc. The compound oil of zedoary turmetric bolt has the function of promoting flow of qi and blood circulation, clearing away the heat-evil and expelling superficial evils and enhancing organism immunizing ability; ice slabs could remove putrefaction, relieve inflammation, alleviate pain and promote wound surface cicatrizing. It has good effect in curing desquamation colpitis.

Description

technical field [0001] The invention relates to the application of compound curcuma oil suppository in the preparation of medicine for treating desquamative vaginitis, belonging to the technical field of medicine and pharmacy. Background technique [0002] Vaginitis is a common disease and frequently-occurring disease of women, which brings many miseries to patients and seriously affects the health of women in general. One of the more commonly used treatment methods and medicines used at present is a compound preparation made of zedoary oil, such as suppositories, foams, etc. For example, Candida albicans vaginal infection, fungal vaginitis, trichomonas vaginitis, bacterial vaginosis, etc., can be treated with traditional Chinese medicine prescriptions, metronidazole, econazole nitrate, and zedoary oil. [0003] Desquamative inflammatory vaginitis (DIV. See Sweet RL, Gibbs RS. Infectious Diseases of the Female Genital Tract. 2002, Lippincott Williams & Wilkins, USA: 351-352...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/02A61P15/02
Inventor 韩志强
Owner SUNSTONE TANGSHAN PHARM CO LTD
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