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Spray for treating cutaneous moniliasis

A candida and spray technology, applied in the field of sprays for the treatment of skin candidiasis, can solve the problems of rising daily treatment costs, high prices, and increased frequency of use of high-end antifungal drugs, so as to improve the safety of medication and prevent fungal infections. High killing rate and quick effect

Inactive Publication Date: 2019-02-19
辽宁新高制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the frequency of expensive and high-end antifungal drugs is increasing, and the overall daily treatment cost is rising

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A spray for the treatment of skin candidiasis, which is made of the following raw materials according to the mass ratio: 0.2g of econazole nitrate, 0.5g of polysorbate-80, 3g of propylene glycol, 40g of ethanol, 0.01g of rose essence, The balance of purified water;

[0021] A kind of spray that is used for the treatment of skin candidiasis, its preparation method comprises the steps:

[0022] a. Take polysorbate-80, propylene glycol, and part of 95% ethanol, heat at 40°C, and mix thoroughly to obtain solution I;

[0023] b. Take econazole nitrate, fully stir and dissolve with solution I to obtain solution II;

[0024] c. Add the remaining 95% ethanol to solution II, add an appropriate amount of purified water to make up to 100mL, add rose essence, and finally adjust the solution volume to the final solution volume, fill and pack.

Embodiment 2

[0026] A spray for the treatment of skin candidiasis, which is made of the following raw materials according to the proportion by mass: 0.6g of econazole nitrate, 1.5g of polysorbate-80, 6g of propylene glycol, 25g of ethanol, 0.03g of rose essence, Purified water to make up the balance;

[0027] A kind of spray that is used for the treatment of skin candidiasis, its preparation method comprises the steps:

[0028] a. Take polysorbate-80, propylene glycol, and part of 95% ethanol, heat at 40°C, and mix thoroughly to obtain solution I;

[0029] b. Take econazole nitrate, fully stir and dissolve with solution I to obtain solution II;

[0030] c. Add the remaining 95% ethanol to solution II, add an appropriate amount of purified water to make up to 100mL, add rose essence, and finally adjust the solution volume to the final solution volume, fill it, and pack it.

Embodiment 3

[0032] A spray for the treatment of skin candidiasis, which is made of the following raw materials according to the mass ratio: 1.0g econazole nitrate, 2.0g polysorbate-80, 20g propylene glycol, 10g ethanol, 0.05g rose essence, Purified water to make up the balance;

[0033] A kind of spray that is used for the treatment of skin candidiasis, its preparation method comprises the steps:

[0034] a. Take polysorbate-80, propylene glycol, and part of 95% ethanol, heat at 40°C, and mix thoroughly to obtain solution I;

[0035] b. Take econazole nitrate, fully stir and dissolve with solution I to obtain solution II;

[0036] c. Add the remaining 95% ethanol to solution II, add an appropriate amount of purified water to make up to 100mL, add rose essence, and finally adjust the solution volume to the final solution volume, fill it, and pack it.

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PUM

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Abstract

The invention belongs to the field of external-use medicine, and provides a spray for treating cutaneous moniliasis. The spray is prepared from econazole nitrate, polysorbate-80, propylene glycol, ethanol, purified water and rose essence. The spray for treating the cutaneous moniliasis has the advantages that the stability of the econazole nitrate as a pharmaceutical active ingredient, as well asthe stability of the pharmaceutical preparation are improved through interaction of the components; the transdermal absorption is fast, and the antibacterial effect is good; the spray is convenient toprepare and use, and low in cost, thereby being an effective fungicide.

Description

technical field [0001] The invention belongs to the field of medicine for external use, in particular to a spray for treating skin candidiasis. Background technique [0002] In recent years, due to the extensive application of broad-spectrum antibiotics, adrenocortical hormones, antineoplastic drugs, immunosuppressants and invasive operations, the flora imbalance and the body's resistance to fungi have decreased, resulting in the incidence of superficial and deep mycoses increasing day by day. In addition, since fungi and human cells are both eukaryotic cells, they often have considerable toxicity to the host after long-term drug use, and the emergence of drug-resistant strains has a tendency to increase day by day. Therefore, it is extremely difficult to treat antifungals. Among them, the infection of Candida is particularly prominent, and it occupies a high proportion in many clinically isolated fungal strains, as high as more than 90%. Among the cases of deep fungal in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/26A61K47/10A61K31/4174A61P17/00A61P31/10
CPCA61K9/12A61K31/4174A61K47/10A61K47/26A61P17/00A61P31/10
Inventor 杨朝辉杨启家齐海峰
Owner 辽宁新高制药有限公司
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