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Econazole nitrate microemulsion and preparation method and application thereof

A technology of econazole nitrate microemulsion and microemulsion, which is used in pharmaceutical formulations, emulsion delivery, medical preparations containing active ingredients, etc. good reproducibility

Active Publication Date: 2015-05-20
SHANXI YUANYANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Studies at home and abroad have shown that econazole nitrate is a broad-spectrum antifungal drug, which has bactericidal and bacteriostatic effects on dermatophytes, yeasts, biphasic fungi, and aspergillus. The drug of choice for superficial fungal infections such as tinea versicolor and candidal dermatitis, but econazole nitrate has a significant effect in the treatment of fungal infections such as mold and candidal vaginitis, but there are recurrent phenomena Therefore, how to make econazole nitrate act for a long time and have a thorough therapeutic effect has become an urgent research topic.

Method used

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  • Econazole nitrate microemulsion and preparation method and application thereof
  • Econazole nitrate microemulsion and preparation method and application thereof
  • Econazole nitrate microemulsion and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0189] The econazole nitrate microemulsion described in the present embodiment is made up of following components:

[0190]

[0191] The econazole nitrate microemulsion described in this example is prepared according to the following method: take the step of mixing the oil phase, surfactant, co-surfactant and water phase to obtain a blank microemulsion according to the selected prescription, and add Mix the prescribed amount of econazole nitrate, and you get it.

Embodiment 2

[0193] The econazole nitrate microemulsion described in the present embodiment is made up of following components:

[0194]

[0195]

[0196] The econazole nitrate microemulsion described in this example is prepared according to the following method: take the step of mixing the oil phase, surfactant, co-surfactant and water phase to obtain a blank microemulsion according to the selected prescription, and add Mix the prescribed amount of econazole nitrate, and you get it.

Embodiment 3

[0198] The econazole nitrate microemulsion described in the present embodiment is made up of following components:

[0199]

[0200] The econazole nitrate microemulsion described in this example is prepared according to the following method: take the step of mixing the oil phase, surfactant, co-surfactant and water phase to obtain a blank microemulsion according to the selected prescription, and add Mix the prescribed amount of econazole nitrate, and you get it.

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Abstract

The invention belongs to the technical field of medicine preparations, particularly relates to an econazole nitrate microemulsion and a preparation method and application thereof, and discloses the econazole nitrate microemulsion. The pharmaceutical composition is prepared from econazole nitrate, a surfactant and a cosurfactant; an oil phase is mixed at a certain ratio; the surfactant is Tween; the cosurfactant is absolute ethyl alcohol; and the oil phase is ethyl butyrate. The econazole nitrate microemulsion disclosed by the invention is simple in prescription, convenient to operate, simple in preparation technology, uniform in particle distribution, small in viscosity, transparent, good in stability and adsorbability, high in bioavailability, long in half-life period, small in side effect of the medicine effect, and controllable in quality; and the product is good in repeatability, and convenient to popularize and utilize.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a microemulsion of econazole nitrate and a preparation method and application thereof. Background technique [0002] The microemulsion structure was first discovered by British chemists Sculman and Hoar in 1943. And in 1959 officially named microemulsion (microemulsion). The microemulsion structure is a homogeneous system of thermodynamically stable oil-water-surfactant-cosurfactant, transparent or nearly transparent in appearance, and is also divided into w / o and o / w types like general emulsions, with small particle size, usually Between 10-100nm, it is also called microemulsion (Nanoemulsion, NE). The special structure of microemulsion has made considerable progress in many fields and has become an important and very active branch of interfacial chemistry. Microemulsion technology has penetrated into the fields of daily chemical industry, fine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/12A61K31/4174A61P31/10
Inventor 林卫瑞冯前进李晓林
Owner SHANXI YUANYANG PHARMA TECH
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