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Compound zedoary oil foam dose and preparing method thereof

A technology of zedoary turmeric oil and foaming agent, which is applied in the field of compound turmeric seed oil foaming agent and its preparation, can solve the problems of narrow distribution surface, easy contamination of drugs, cross infection and the like

Inactive Publication Date: 2008-06-18
郑起平 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But suppository belongs to solid dosage form, and it has some problems when it is actually used, and suppository has a process of softening and dissolving in vagina, and exerts drug effect slowly, and medicine dispersion is uneven, and spreading area is narrow; Contaminate the medicine, and may cause cross-infection; in addition, if the suppository is used, the patient will feel a foreign body sensation in the body, which will bring discomfort to the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: According to the above research, 12.5g of econazole nitrate, 50.25g of zedoary oil, 100g of glycerin, 50g of polysorbate-80, and water were added to make 1000g. Take the above-mentioned acid econazole and turmeric oil raw materials, add propylene glycol, appropriate amount of water and mix with polysorbate-80 to dissolve, then add glycerin and sodium lauryl sulfate respectively, and add water to about 950g, stir to dissolve, Add water to 1000g, mix well, adjust the pH value to acidic, filter, pour into the container, screw on the foam emulsion pump (or foam pump, manual foam generating device), and generate foam by hand-pressing the emulsion pump.

Embodiment 2

[0026] Example 2: According to the above research, take 25g of econazole nitrate, 105g of zedoary oil, 100g of glycerin, 50g of polysorbate-8050g, add water etc. to make 1000g altogether. Take the above-mentioned acid econazole and turmeric oil raw materials, add propylene glycol, appropriate amount of water and mix with polysorbate-80 to dissolve, then add glycerin and sodium lauryl sulfate respectively, and add water to about 950g, stir to dissolve, Add water to 1000g, mix well, adjust the pH value to acidic, filter, pour into the container, screw on the foam emulsion pump (or foam pump, manual foam generating device), and generate foam by hand-pressing the emulsion pump.

Embodiment 3

[0027] Example 3: According to the above research, 50 g of econazole nitrate, 210 g of zedoary oil, 100 g of glycerin, 50 g of polysorbate-80, and water were added to make 1000 g. Take the above-mentioned acid econazole and turmeric oil raw materials, add propylene glycol, appropriate amount of water and mix with polysorbate-80 to dissolve, then add glycerin and sodium lauryl sulfate respectively, and add water to about 950g, stir to dissolve, Add water to 1000g, mix well, adjust the pH value to acidic, filter, pour into the container, screw on the foam emulsion pump (or foam pump, manual foam generating device), and generate foam by hand-pressing the emulsion pump.

[0028] According to the above prescription and preparation method, the prepared compound curcuma oil foam agent solution is uniform, the foam is rich and the duration is long, which shows that the process is feasible.

[0029]How to use: Before using this product, take a spare cannula (the cannula is for one-time...

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PUM

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Abstract

The invention discloses a compound zedoary-turmeric-oil foam agent and the preparation method. The invention is characterized in that econazole nitrate, zedoary-turmeric oil and so on which serve as raw material and excipient are poured together into a container, then a foam-emulsion pump (or called foam pump or manual foam-generating device) is covered in a twisted way to generate foam by manually pressing the emulsion pump. The preparation method includes the following steps: first take econazole nitrate and zedoary-turmeric oil to mix evenly with polysorbate-80; add propanediol, water of proper amount for dissolution; then add polysorbate-80, lauryl sodium sulfate, propanediol, glycerin and so on, and mix evenly; add distilled water to total amount and mix evenly to adjust pH value; pour into the container and cover with the foam-emulsion pump (or called foam pump or manual foam-generating device) in a twisted way. Then the foam can be generated by manually pressing the emulsion pump. Generating foam by using medicine, emulsifier and a foam-emulsion pump and by pressing the foam-emulsion pump manually can save the cost, eliminate the environmental pollution caused by adding propellant and reduce the explosion probability of pressure vessels, so that the foam-generating process is safer. The invention is a novel foam agent of simple preparation, low cost, security and environmental protection. The compound zedoary-turmeric-oil foam agent can have the medicine distributed evenly in the vaginal canal and the surface of the skin and coated extensively, so at to filter into the vagina mucosa plica rapidly and effectively. The invention which is a good medicine for treating gynecologic diseases has the advantages of sufficient and rapid exertion of the curative effect, good curative effect, safe, sanitary and convenient usage.

Description

technical field [0001] The invention relates to a foaming agent and a manufacturing process thereof, in particular to a compound curcuma oil foaming agent and a preparation method thereof. Background technique [0002] Foams (i.e. emulsion type aerosols) have been recorded in Chinese Pharmacopoeia and Ministry Standards as a pharmaceutical dosage form. Foams are usually raw materials or traditional Chinese medicines, which are extracted and prepared with appropriate amount of auxiliary materials. It is made by filling the pressure vessel with propellant. [0003] Gynecological inflammation is a kind of common, frequently-occurring disease, treats this kind of disease at present, curative effect is good, and the drug dosage form that uses more conveniently is suppository. But suppository belongs to solid dosage form, and it has some problems when it is actually used, and suppository has a process of softening and dissolving in vagina, and exerts drug effect slowly, and medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61K9/12A61K47/34A61P15/00A61K31/4164A61K47/26
Inventor 郑起平吕武清
Owner 郑起平
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