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External use emulsifiable paste for treating skin diseases and with econazole nitrate and triamcinolone acetonide as active components and preparation method

A technology of econazole nitrate and external cream, applied in the field of medicine, can solve the problems of skin irritation, high viscosity of propylene glycol, etc., and achieve the effects of long half-life, low viscosity, easy coating and washing off

Inactive Publication Date: 2016-03-16
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN1813770A discloses triamcinolone acetonide econazole gel, by adding 80% propylene glycol to increase solubility, but propylene glycol is viscous and has certain irritation to the skin

Method used

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  • External use emulsifiable paste for treating skin diseases and with econazole nitrate and triamcinolone acetonide as active components and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Triamcinolone acetonide econazole cream, 100g includes the following components: 10g econazole nitrate, 1g triamcinolone acetonide, 5.5g glyceryl mono- and distearate, 15.5g stearic acid, 3.7g white petrolatum, light Liquid paraffin 3.2g, glycerin 12.6g, triethanolamine 3.7g, ethylparaben 0.15g, borax 0.24g, dimethyl sulfoxide 2.5g, and the balance is distilled water.

[0017] The preparation method of triamcinolone acetonide econazole cream, concrete steps are as follows:

[0018] (1) Preparation of the oil phase: Dissolve the ethylparaben in the prescribed amount of dimethyl sulfoxide, then add the prescribed amount of glyceryl mono- and distearate, stearic acid, white vaseline, light liquid, Heat to 80°C and keep stirring for 30 minutes. spare.

[0019] (2) Water phase preparation: take the formulated amount of glycerin and triethanolamine and distilled water to dissolve, heat to 60° C., then add the formulated amount of borax, mix evenly, pass through a 150-mesh s...

Embodiment 2

[0022] Triamcinolone acetonide econazole cream, 100g contains the following components: econazole nitrate 10g, triamcinolone acetonide 1g, glyceryl mono- and distearate 7g, stearic acid 18g, white petrolatum 6g, light liquid paraffin 5g, glycerin 15g, triethanolamine 7g, ethylparaben 0.3g, borax 0.32g, dimethyl sulfoxide 4g, and the balance is distilled water.

[0023] The preparation method of triamcinolone acetonide econazole cream, concrete steps are as follows:

[0024] (1) Preparation of the oil phase: Dissolve the ethylparaben in the prescribed amount of dimethyl sulfoxide, then add the prescribed amount of glyceryl mono- and distearate, stearic acid, white vaseline, light liquid, Heat to 80°C and keep stirring for 30 minutes. spare.

[0025] (2) Water phase preparation: take the formulated amount of glycerin and triethanolamine and distilled water to dissolve, heat to 60° C., then add the formulated amount of borax, mix evenly, pass through a 150-mesh sieve, and use i...

Embodiment 3

[0028] Triamcinolone acetonide econazole cream, 100g contains the following components: econazole nitrate 10g, triamcinolone acetonide 1g, glyceryl mono- and distearate 5g, stearic acid 12g, white petrolatum 3.4g, light liquid 1.2g of paraffin, 10g of glycerin, 3g of triethanolamine, 0.1g of ethylparaben, 0.12g of borax, 1g of dimethyl sulfoxide, and the balance is distilled water.

[0029] The preparation method of triamcinolone acetonide econazole cream, concrete steps are as follows:

[0030] (1) Preparation of oil phase: Dissolve the ethylparaben of the formula quantity with the dimethyl sulfoxide of the formula quantity, then add the mono- and distearic acid glycerides, stearic acid, white vaseline, light liquid paraffin of the formula quantity , heated to 80°C, and kept stirring for 30 minutes. spare.

[0031] (2) Water phase preparation: take the formulated amount of glycerin and triethanolamine and distilled water to dissolve, heat to 60° C., then add the formulated ...

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Abstract

The invention discloses external use emulsifiable paste for treating skin diseases and with econazole nitrate and triamcinolone acetonide as active components and a preparation method. The triamcinolone acetonide and econazole emulsifiable paste is prepared from, by weight, 10 parts of econazole nitrate, 1 part of triamcinolone acetonide, 3-10 parts of glycerin monostearate and glycerol distearate, 10-20 parts of stearic acid, 1-10 parts of albolene, 0.8-7 parts of light liquid paraffin, 8-17 parts of glycerinum, 1-10 parts of triethanolamine, 0.08-0.5 part of ethylparaben, 0.08-0.5 part of borax, 0.5-5 parts of dimethyl sulfoxide and 10-60 parts of distilled water. The preparation method includes the steps of oil phase preparation, water phase preparation and finished product preparation. The preparation method includes the steps of oil phase preparation, water phase preparation and finished product preparation. The paste has the advantages that by means of the optimized formula, stability of the preparation is improved, the problem that econazole nitrate and triamcinolone acetonide are difficult to dissolve is solved, and the complex skin diseases caused by fungus and bacterial infection are effectively treated.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a chemical drug for treating skin diseases. Background technique [0002] Triamcinolone acetonide econazole cream consists of econazole nitrate, triamcinolone acetonide, water phase and oil phase. Econazole nitrate is an imidazole broad-spectrum antifungal drug, which can effectively kill Gram-positive bacteria in skin infections and fungi such as dermatophytes, candida, plaster-like tinea, rubrum, and mold. Triamcinolone acetonide is a medium-acting glucocorticoid with good anti-inflammatory, antipruritic and anti-allergic effects. In recent years, the incidence of skin tinea caused by fungal infection, such as tinea manus, jock itch, onychomycosis, tinea capitis, etc., has become more and more frequent, and has the characteristics of easy infection, easy recurrence or reinfection, which brings physical pain to patients. and psychological harm. Therefore, the combination o...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K9/06A61P17/00A61P31/10A61P31/04A61K31/4174
Inventor 曹翠阎君白冰林子琦于施刘学锋
Owner 吉林修正药业新药开发有限公司
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