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Compound econazole nitrate film forming gel composition and its use

A technology of econazole nitrate and gel composition is applied in the directions of drug combination, medical preparations without active ingredients, medical preparations containing active ingredients, etc. The effect of good biocompatibility, good flexibility and easy availability of raw materials

Inactive Publication Date: 2007-01-24
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture prematurely, fall off, and even disappear, and its effective residence time on the oral mucosa is only 3 to 4 hours
[0006] Therefore, as adopting the technology of above-mentioned existing film-forming gel composition to prepare compound econazole nitrate film-forming gel composition, then the medicament wherein and the affected part keep time is shorter, have influenced triamcinolone acetonide and econazole nitrate. curative effect

Method used

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  • Compound econazole nitrate film forming gel composition and its use
  • Compound econazole nitrate film forming gel composition and its use
  • Compound econazole nitrate film forming gel composition and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～14

[0037] Embodiment 1~14 and comparative embodiment

[0038] Econazole nitrate, triamcinolone acetonide (without adding econazole nitrate and triamcinolone acetonide) of each consumption in the embodiment 1-14 in table 1 and the comparative example (the embodiment represented by "*") respectively De) and esterifying agent are stirred and dissolved in a dissolvable amount of solvent, and slowly add hydroxypropyl cellulose under stirring to completely dissolve / swell, then continue to stir to form a uniform gel; then add enhancer as needed And / or cross-linking agent, continue to stir to make completely uniform; Supplement the solvent of remaining amount, make to reach recipe quantity, stir, degassing, obtain the compound recipe econazole nitrate film-forming gel composition of the present invention respectively 100 grams.

[0039] The experimental results show that the compound econazole nitrate film-forming gel composition is translucent yellow in appearance, and can form a smooth...

Embodiment 2

[0046] Take the compound econazole nitrate film-forming gel composition prepared in Examples 2-14, the sample prepared according to the method of Example 1 of US Patent USP5081158, referred to as USP Gel-A, and add econazole nitrate and triamcinolone in the formula De (formulation w / w: econazole nitrate 1.0%, triamcinolone acetonide 0.1%, hydroxypropyl cellulose 2.5%, salicylic acid 2.5%, tannic acid 7%, boric acid 1%, ethanol 85.9%), press The sample prepared by the embodiment Gel D method of USP5906814, referred to as USP Gel-B, replaces benzocaine with econazole nitrate and triamcinolone acetonide (formulation w / w: econazole nitrate 1.0%, triamcinolone acetonide 0.1%) %, hydroxypropyl cellulose 1.5%, salicylic acid 2.0%, lauric monoglyceride 5.0%, edetate disodium salt 0.05%, vitamin E 0.1%, ethanol 90.25%, etc.) for in vitro skin adhesion properties , corrosion phenomenon and residence time comparison, the latter two as a control.

[0047] Take 3×4cm fresh back skin of ra...

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Abstract

The compound econazole nitrate film forming gel composition consists of hydroxyalkyl cellulose 0.5-7 wt%, esterifying agent 1-10 wt%, crosslink agent 0.5- 5 wt%, reinforcer 0-5 wt%, solvent 75-90 wt%, econazole nitrate 0.1-5 wt% and triamcinoline aceonide 0.01-3 wt%. The crosslink agent is saturated fatty polyol or alcohol acid in the general expression of CnH2n+2-m-l(OH)m(COOH)l, where, n, m, l are integrals, m is n-2, l is not smaller than 0, m+l is 4-8, and n+l is 4-8. The compound econazole nitrate film forming gel composition is used in treating local fungal inflammation through coating to surface of skin to form one smooth tough antiwear hydrophobic protecting film.

Description

technical field [0001] The invention relates to a local film-forming gel composition, in particular to a compound econazole nitrate film-forming gel composition containing econazole nitrate and triamcinolone acetonide and its preparation for treating local fungal inflammation of the body in the application. Background technique [0002] Body skin ringworm caused by fungal infection, such as athlete's foot, tinea corporis, jock itch, etc. is a common disease that is often encountered in people's daily life. The topical pharmaceutical preparations clinically used to treat these diseases are usually creams, ointments, gels, liniments, etc., such as compound nitric acid with antifungal drugs such as econazole nitrate and hormones such as triamcinolone acetonide as active ingredients Econazole preparations, etc. Among them, Econazole Nitrate (EconazoleNitrate) is a kind of imidazole broad-spectrum antifungal drug, which is effective against Epidermophyton flocculus, Tinea capit...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K31/58A61K31/4164A61K9/70A61P17/00A61P31/10
Inventor 马晋隆倪旻陈志明卢艳萍
Owner SHANGHAI INST OF PHARMA IND
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