132results about How to "Improve transdermal absorption rate" patented technology

Pharmaceutical compositions for the transdermal administration of a medicament or other active agent by topical application of the composition to the skin of humans or other animals are described. Methodology for formulating such compositions which provide for very rapid uptake of the medicament and transmigration into and through the skin to either fatty tissues or the vascular system, while minimizing irritation to the skin and / or immunological response, is based on a transdermal delivery system (TDS) wherein the medicament is modified to form a true solution in a complex formed from particular solvents and solvent and solute modifiers in combination with skin stabilizers. Uptake of the medicament is further facilitated and made more rapid by including Forskolin or other source of cellular energy, namely induction of cAMP or cGMP. Selection of specific solvents and solvent and solute modifiers and other functional ingredients and the amounts thereof are chosen such that there is a balance between the sum of the mole-moments [(molar amount of each individual ingredient)x(dipole moment of that ingredient)] of the delivery system and the sum of the moler moments of the composition in which the medicament is dissolved. Preferably, the van der Waals forces of the delivery system is also similarly matched to the van der Waals forces of the total composition, namely, delivery system plus active agent.

A transdermal delivery system (TDS) for use in treatment of living bodies may be applied as an open (liquid, gel) or closed (patch) article. The TDS is composed of a particular active agent which dictates an associated selection of certain solvents, solvent modifiers, solute modifiers and skin stabilizers with which the medicament forms a true solution that rapidly crosses the skin barrier. The associated selection of the particular solvents, solvent modifiers, solute modifiers and skin stabilizers is based on a balancing of the molecular properties of all the components against the molecular properties of all the components plus the particular active agent. The TDS may also include a source of cellular energy to induce CAMP or cGMP. The TDS improves delivery of active agents having a molecular weight greater than 340 Daltons and increases dosage above 0.25 mg / day for such active agents.

The invention discloses an anti-inflammation and allergy-relieving repair composition and a preparation method and an application thereof. The composition consists of a cactus extract, an oat bran extract, a sophorae flavescentis extract, an ophiopogon japonicus root extract, a peony root extract, a scutellaria baicalensis root extract, butanediol, pentanediol and water. The preparation method comprises the following steps: 1) preparing a sophorae flavescentis extract solution; 2) carrying out super-high pressure homogenization of the cactus extract, the oat bran extract, the ophiopogon japonicus root extract, the peony root extract, the scutellaria baicalensis root extract, butanediol and pentanediol to obtain a plant extract mixed solution; and 3) carrying out mixing, super-high pressurehomogenization and filtration of the plant extract mixed solution and the sophorae flavescentis extract solution. The anti-inflammation and allergy-relieving repair composition has anti-inflammatory,anti-allergic and analgesic effects, can enhance skin barrier function, enhances the skin self-protection ability, effectively repairs inflammatory skin, especially skins suffered from hormone-dependent dermatitis and cannot produce drug resistance, dependence and side effects after being used for a long time.

The invention provides a hydrolyzed collagen liposome solution mainly used for repairing skin damages caused by various factors. According to the invention, the hydrolyzed collagen liposome solution is prepared from a phospholipid, a ceramide and cholesterol, a percutaneous stratum corneum of hydrolyzed collagen is promoted to enter the skin, and the retention of the hydrolyzed collagen in the skin is improved, so that the recovery of the skin damages is effectively promoted. Furthermore, the solution contains hyaluronic acid to improve the stability of the liposome and delay leakage.

The invention discloses a nano-grade gynaecologic lotion, which is characterized in that: the granularity of the lotion is 1 to 100nm, the lotion is made of the following raw materials in percentage by weight: 20 to 40 percent of surface active agent, 1 to 10 percent of cosurfactant, 0.2 to 5 percent of oil phase, 1 to 20 percent of myrrh oil, 0.02 to 5 percent of nanometer silver collosol, 1 to 5 percent of Aloe extract, 0.1 percent of glacial acetic acid and the balance of deionized water, the sum of the mass percent of the above raw materials is 100 percent. The nano-grade gynaecological lotion has characteristic that the lotion can cure gynecology inflammations caused by various pathogenic bacteria, the bacteria killing rate can reach to 100 percent within two minutes, the drug resistance is free from being produced, a sterilization function and an antipruritic effect can be realized, ingredients contained in the lotion can nourish the vagina, the skin on which the inflammations occur can be promoted to heal, and the treatment period can be shortened.

The invention relates to the field of medical / cosmetic apparatuses, and in particular relates to scar-repairing silica gel containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The scar-repairing silica gel can be used for repairing hyperplastic scars or keloids caused by burns, scalds, trauma, operations and the like in the medical / cosmetic field. The scar-repairing silica gel contains the human-like collagen, silica, cyclopentasiloxane, dimethiconol, water and polydimethylsiloxane.

The present invention relates to a solubilized cosmetic composition which uses an oleanolic acid entrapped in nano-liposomes as an active ingredient. The present invention can increase percutaneous absorption of an active ingredient using nano-liposomes to promote synthesis of collagen, thus providing a good anti-wrinkle effect. Also, since other additional raw materials are not used for capsulation, the manufacturing cost of a product can be reduced, and a good sensation during use can be provided.

The invention relates to the technical fields of the biomedicine and the skin health-care and facial cosmetics, in particular to a composite nanoemulsion used for epidermis repair and a preparation method thereof. The product prepared in the invention can quicken the injured epidermis repair and the epidermis barrier function repair, can improve the stability of protein polypeptide drugs or efficacy compositions and enhance the dissolvability of the difficultly dissolved matter and the stability of the easily hydrolyzed matter by promoting the skin to permeate and absorb the efficacy compositions of the epidermis, can scientifically and reasonably match natural drugs, antioxidants and biological derived skin repair polypeptide, and can exert the better epidermis repair efficiency and speed by combining the high-efficiency skin delivery carrier blank nanoemulsion system. Moreover, the product prepared in the invention can also improve the nutrition and moisturizing capabilities of the skin greatly, create an appropriate micro-ecological environment for the epidermis repair and enhance the synergism of the efficacy compositions. In addition, the product prepared in the invention can not contain the preservative and the essence, lowers the toxicity, improves the safety and can be industrially produced without adopting special equipment and energy.

The invention discloses an eye patch. The eye patch comprises the following constituents of, by weight, 0.002 to 5 parts of xanthophylls, 0.002 to 5 parts of coix seeds, 0.002 to 5 parts of cassia seeds, 0.002 to 5 parts of ginseng stems and leaves, 0.002 to 5 parts of pearl powder, 0.002 to 5 parts of carthamus tinctorius, 0.002 to 5 parts of tree peony bark, 0.002 to 5 parts of salvia miltiorrhiza, 0.002 to 5 parts of golden cypress, 0.002 to 5 parts of spica prunella, 0.002 to 5 parts of chrysanthemum extract, 0.002 to 5 parts of mint, 0.002 to 5 parts of borneol, 0.002 to 5 parts of glycerinum, 0.001 to 1 part of sodium hyaluronate, 0.001 to 4 parts of propylene glycol, 0.001 to 1 part of metal complexes and 0.001 to 1 part of essence. The constituents are evenly emulsified in an emulsification tank and the formed eye patch is filled with the constituents, so that the eye patch is obtained. The eye patch is pasted to the corresponding eye and xanthophylls is directly absorbed through the eye skin; the sodium hyaluronate is added to a formula to serve as a skin penetration enhancer, so that the skin penetration absorption rate of the xanthophylls is increased. Meanwhile, the constituents with the blood invigorating function, the gout disperse and heat removing function and the liver fire removing and eyesight improving functions are added to the formula, the constituents with the water replenishing and moisture maintaining function are added at the same time, and therefore the multiple effects of treating pseudomyopia and preventing and treating xerophthalmia, cataract and age-related macular degeneration, protecting the eyes and improving the eyesight are achieved.

The invention relates to a composition with a skin whitening effect, a skin-whitening soluble micro-needle patch with high drug loading capacity, and a preparation method of the skin-whitening solublemicro-needle patch. The composition with the skin whitening effect comprises, by weight, 10-20 parts of arbutin, 10-20 parts of magnesium ascorbyl phosphate, 5-10 parts of adenosine, and 0.1-0.5 partof a sturgeon caviar. The skin-whitening soluble micro-needle patch comprises a pinpoint and a substrate, and the pinpoint is prepared from the composition with the skin whitening effect, hyaluronicacid or sodium hyaluronate, and a micro-needle auxiliary material, wherein the mass ratio of the composition with the skin whitening effect to hyaluronic acid or sodium hyaluronate to the micro-needleauxiliary material is 1 to 0.1-5 to 0.2-1; and the micro-needle auxiliary material is composed of polyvinylpyrrolidone, glycerol and hydroxypropyl cellulose. The skin-whitening soluble micro-needle patch has the high drug loading capacity, excellent mechanical performance, and good effects of skin whitening, spot fading and moisture preserving.

The invention discloses a layered facial mask. The layered facial mask contains a two-layer structure and a three-layer structure. The two-layer structure comprises a facial mask inner layer and a facial mask outer layer. The three-layer structure comprises a facial mask inner layer, a facial mask middle layer and a facial mask outer layer. The facial inner layers contain active component layers respectively. The facial middle layer is a storage layer. The facial mask outer layers are water supplementing protection layers. In the two-layer facial mask, because active components concentrate in the facial mask inner layer close to skin, the diffusion distance of the active components of the facial mask to a face is shortened, the transdermal absorption ratio in unit time is raised, and residual of the active components is reduced. Because the three-layer facial mask contains the active component storage layer, the active components release slowly, and thus the facial mask can be used for multiple times. The azone content is controlled, and the facial mask is beautiful. The hydrolyzed collagen content is adjusted, and facial mask molding is easy and the toughness is proper. The matrix part of the facial mask outer layer has a water supplementing function. Because the different layers of the facial mask employs the same matrix, the facial mask is milky or transparent and has uniformity.

The invention relates to the field of medical / beauty equipment, in particular to a hydrogel collagen dressing which is especially suitable for oily skin. The collagen dressing of the present invention comprises water, collagen and macromolecular polymers distributed in the water. It can promote rapid transdermal absorption of collagen, so it is more suitable as a medical / cosmetic collagen dressing in the field of medical treatment or medical cosmetology.

The invention provides a medicinal paste for treating Chinese honeylocust spine and hyperosteogeny and its preparing process, wherein the raw material herbs include the following constituents (by weight ratio): Chinese angelica root, Chinese ephedra, rhubarb horsetails, radix paeoniae rubrathe, dried rehmannia root, goldthread root, licorice root, thunberg fritillary bulb, honeysuckle flower, safflower, stem pith of the ricepapr plant, dahurian angelica root, radix aconiti. and the preparing process steps of cooling down the plaster and charging the following fine materials: pangolin scales, camphor, musk, boneol, frankincense, myrrh, and dragon's blood resin.

The invention relates to a flurbiprofen cataplasm preparation. The flurbiprofen cataplasm preparation consists of a back lining layer, a medicine depot and a protective layer, and is characterized in that the medicine depot is prepared from the following components in percentage by weight: 0.2% to 0.5% of flurbiprofen as an active ingredient and 5% to 10% of oil phase component; the oil phase component is prepared from caprin and glycerol monolaurate according to a mass ratio of 1:(0.3-0.4); the flurbiprofen is dispersed into the oil phase, and the part using as the water phase component is used for neutralizing with 5% to 10% of sodium polyacrylate as a water phase component, 20% to 40% of moisturizing agent, 0.5% to 1.5% of Carbomer 980, 1.5% to 3% of CMC-Na (sodium carboxymethylcellulose), 0.1% to 0.2% of NMP (N-methyl pyrrolidone), 0.2% to 0.4% of dihydroxyaluminum aminoacetate, 0.1% to 0.3% of EDTA-2Na, 1% to 3% of filling agent, and the balance of water.

The invention relates to a composite acne removing lipid nanoparticle emulsion and a preparation method of the composite acne removing lipid nanoparticle emulsion. The emulsion contains 1.0-8.0% by mass percentage of composite acne removing active matters which are made up of a vitex agnus-castus extract, a herba centellae extract and tetrahydropiperine according to the mass ratio of (2-10) to (2-16) to 1. The method comprises the steps of weighing the composite acne removing active matters to prepare a liquid oil phase; preparing the liquid state oil phase and distilled water into a mixed solution, circularly homogenizing the mixed solution with pressure of 70-150MPa and temperature of 75-85 degrees centigrade by a high pressure homogenizer, and obtaining the composite acne removing lipid nanoparticle emulsion. The invention has the following advantages: the composite acne removing lipid nanoparticle emulsion simultaneously loaded with three active matters including the vitex agnus-castus extract, the herba centellae extract and tetrahydropiperine can be prepared; the obtained composite acne removing lipid nanoparticle emulsion is good in stability, remarkable in acne removing effect, light in colour, little in peculiar smell, and is conveniently added into the formulas of the cosmetics via a cooling distribution.

The invention discloses a flurbiprofen cataplasm, which consists of a backing layer, a medicament storage space and a protective layer, wherein the medicament storage space consists of the following components in percentage by weight: 0.2 to 0.5 percent of flurbiprofen serving as an active ingredient, 5 to 10 percent of an oil-phase component, 5 to 10 percent of partial neutralization sodium polyacrylate, 20 to 40 percent of a humectant, 0.5 to 1.5 percent of carbomer 980, 1.5 to 3 percent of CMC-Na (sodium carboxymethyl cellulose), 0.2 to 0.4 percent of dihydroxyaluminium aminoacetate, 0.1 to 0.3 percent of EDTA-2Na (disodium ethylene diamine tetraacetic acid, 0.5 to 0.7 percent of tween 80, 1 to 3 percent of a filler and the balance of water, wherein the oil-phase component is prepared from caprin, oleic acid and peregal A-20 in a mass ratio of 1:(0.2 to 0.3):(0.2 to 0.3), and the partial neutralization sodium polyacrylate, the humectant, the carbomer 980, the CMC-Na, the dihydroxyaluminium aminoacetate, the EDTA-2Na and the tween 80 form a water-phase component.

The invention discloses a resveratrol nano-micelle and a preparation method thereof. In order to determine an optimal raw material ratio and various preparation process parameters, a large number of experiments are conducted, and process parameters with a high encapsulation rate are obtained. The physicochemical properties and biological activity of the prepared resveratrol nano-micelle are studied through various experiments. Experiments show that the prepared resveratrol nano-micelle can significantly improve the stability of resveratrol and is high in transdermal absorption rate; pharmacodynamic experiments show that the prepared resveratrol nano-micelle is high in free radical scavenging rate and has a great tyrosine inhibiting effect.

The invention provides an anti-senescence face mask and a preparation method thereof. The anti-senescence face mask is mainly prepared from the following ingredients in percentage by weight: 0.2 to 2 percent of edaravone, 0.2 to 3 percent of hydrolyzed silk, 0.1 to 2 percent of fucose, 0.5 to 5 percent of allantoin, 2.9 to 29 percent of a humectant, 1 to 5 percent of a thickening agent, 0.3 to 5 percent of a stabilizing agent, 0.5 to 5 percent of an emulsifier and the balance of water. The anti-senescence face mask achieves the effects of being capable of effectively resisting senescence, preventing the generation of skin color spots and the hyperpigmentation, and improving the skin microcirculation.

The invention relates to the technical field of medical care, aims at solving the problem that vaginitis is repeatedly caused since the traditional gynecological lotion kills many probiotics while killing pathogenic bacteria and causes vaginal flora imbalance and low vaginal immunity, and provides a gynecological vaginal lotion for adjusting the female vaginal micro-ecosystem and a preparation method thereof. The preparation method comprises the following steps: adding natural perfume having 0.01-0.5 percent of the volume concentration of acidic water into the acidic water, disinfecting, and adjusting the pH value to be 3.5-5.5. According to the method, lactobacillus reproduction is promoted to achieve the aim of inhibiting pathogenic bacteria, the absolute number of dominant bacterium lactobacillus is increased, the number of pathogenic bacteria is reduced, the micro-ecological balance of vagina is maintained, the vaginal cleanness is improved, the vagina mucosa immunity is improved, the gynecological vaginal inflammation is prevented, and the recurrence rate of gynecological vaginitis is reduced. The gynecological vaginal lotion is safe, has a specific pH value range being 3.5-5.5, and is safer and more effective than those of other bacteriostatic agents and bactericides.

The invention relates to a refreshing anti-alopecia shampoo composition with a synergistic effect provided by plant essential oil. The refreshing anti-alopecia shampoo composition contains the commonly used components of a shampoo formula, and further contains, by weight, 0.25-0.5% of caffeine, and 0.5-3.0% of a high geraniol content plant essential oil composition, wherein the high geraniol content plant essential oil composition can effectively promote the transdermal absorption of caffeine so as to synergistically enhance the refreshing and improve the scalp hair follicle growth activity. With the long-term use of the refreshing anti-alopecia shampoo composition, alopecia can be prevented or reduced.

The invention relates to a triptolide transdermal patch, which is prepared by a therapeutically effective amount of triptolide, polyvinylpyrrolidone, a certain amount of pressure-sensitive adhesive, tackifier and penetration enhancer, and the triptolide transdermal patch has the advantages of high transdermal absorption rate and small local irritation on skin, thereby being an ideal triptolide preparation.

A Chinese medicine in the form of ointment for treating hypersteogeny, bone fracture, arthrodynia, arthritis, etc is prepared from multiple Chinese-medicinal materials including Sichuan aconite root, hot pepper, myrrh, safflower, etc. Its preparing process is also disclosed.

The invention discloses a nanoemulsion compound transdermal spray for treating chronic gastritis and gastric ulcer. The nanoemulsion compound transdermal spray is prepared from the following raw materials in percentage by mass: 35-45% of surfactant, 0.5-2% of auxiliary surfactant, 2-6% of fructus amomi oil, 1-4% of patchouli oil, 2-6% of cinnamon oil, 1-4% of atractylis oil, 1-3% of dried tangerine peel oil, 0.2-1% of azone and the balance of deionized water, wherein the sum of the mass percentages of the raw materials is 100%. The compound transdermal spray has rapid and durable pain alleviating action, has the effects of warming stomach and alleviating pain, warming spleen and promoting qi flow, eliminating inflammation and promoting tissue regeneration, improving microcirculation, promoting ulcer healing and the like, and is nontoxic and harmless to human bodies. The compound transdermal spray is applied to skin above navel and can be absorbed through massaging, has aromatic flavor, and does not pollute clothes, thereby greatly improving patient compliance.

The invention discloses a repairing anti-aging facial mask essence and a preparation method thereof. The facial mask essence comprises 0.1-2% of sodium hyaluronate, 0.01-1% of a golden chamomile extract, 0.1-4% of beta-glucan, 2-10% of propylene glycol, 0.5-4% of butanediol, 0.1-3% of acrylic acid / MA copolymer sodium, 2-10% of glycerinum, 0.05-0.5% of saccharomycete fermentation filtrate, 0.1-0.5%of N15 polypeptide, 0.8-1.5% of oligopeptides-1, 0.2-6% of 1,2-hexanediol, 0.2-8% of 1,3-propylene glycol, 0.3-6% of 1,6-hexanediol, 0.1-3% of caprylyl glycol, 0.01-0.15% of decoyl hydroximic acid, 0.1-5% of hexanediol and the balance of water. As natural active components of the saccharomycete fermentation filtrate and the N15 polypeptide are combined together, a skincare product with a repairing anti-aging effect is developed, the transdermal absorption ratios of the active components can be greatly increased, product effects are enriched, and meanwhile, no essence, alcohol or preservativeis used, so that the liquid temperature and low allergy of the facial mask essence are ensured, and skin irritation can be reduced. Meanwhile, the facial mask essence is simple in preparation process,gentle in reaction condition, low in raw material price and easy in raw material obtaining, and the preparation cost can be greatly reduced.

The invention provides a facial mask with an after-sun repair function and a preparation method of the facial mask. The facial mask with the after-sun repair function is prepared from the following components in percentage by weight: 0.5-1.5 % of safflower yellow, 0.1-0.8 % of hydrolyzed silk, 0.5-5 % of mycose, 0.5-2 % of allantoin, 2.9-15.5 % of a humectant, 1-5 % of a thickener, 0.5-1 % of a stabilizer, 0.5-2.5 % of an emulsifier, and the balance of water. The facial mask provided by the invention can effectively inhibit after-sun melanin formation and whiten the skin, also can improve the skin microcirculation and promote the after-sun skin repair.

The invention relates to the technical field of liposome wrapping, in particular to a method for wrapping stable retinoid and application. The method for wrapping stable retinoid is characterized in that a lipid solution is provided, retinoid is added into the lipid solution, the lipid solution is oscillated, and the lipid solution at least comprises (a) 0.1-10% of ester with the IOB value of 0.2-0.6 and (b) 8-30% of water-soluble polymer on the basis of the total mass of the lipid solution. According to the method for wrapping the stable retinoid, a dual-vitamin A or multi-vitamin A anti-aging system is utilized, and a liposome coating process is matched, so that the transdermal absorption rate of active ingredients is remarkably improved, and the effects of deep oxidation resistance and aging resistance are achieved, meanwhile, the problems of poor stability and large irritation of active particles are solved by utilizing the combination of special components in the lipid solution, and the self-control slow release of the active components is also realized, so that the utilization rate of the active components is improved.

The invention relates to the technical field of veterinary drugs, and specifically relates to a traditional Chinese medicine perfusate for treating cow mastitis as well as a preparation and application method thereof. The traditional Chinese medicine perfusate comprises the following materials in parts by weight: 1 part of a folium cortex eucommiae extract, and 1-3 parts of tea tree essential oil, wherein the folium cortex eucommiae extract and the tea tree essential oil are mixed to form mixed oil; auxiliary materials are added into the mixed oil to prepare the perfusate; the auxiliary materials include soybean oil, glycerinum, glycerin monostearate, ethylparaben, cyclodextrin, vaseline and distilled water. According to the traditional Chinese medicine perfusate, the folium cortex eucommiae extract is used as the effective component, so that the traditional Chinese medicine perfusate has the effects of clearing away heat and toxic materials, fighting bacteria and diminishing inflammation, and has an outstanding effect on treating clinical cow mastitis; the tea tree essential oil is compounded, thus the antibacterial activity of the traditional Chinese medicine perfusate is improved, and moreover, the permeability is greatly improved; the traditional Chinese medicine perfusate does not contain any chemical medicine components, so that the safety of milk products can be ensured; and the drug tolerance is hardly caused.

The Chinese medicine ointment for treat bone diseases is prepared through sorting Chinese medicinal materials, stoving, crushing into coarse powder, sieving, decoction, purification, emulsification and forming cream ointment. It has wide application range, and is suitable for treat pain in cervical and lumber vertebra, hyperosteogeny, protrusion of lumbar intervertebral disc, scapulohumeral periarthritis, rheumarthritis, etc. It has high healing effect and high transdermal absorption, reaching treating internal diseases externally.

The invention aims to provide a method for extracting an effective component of cotton rose hibiscus leaves based on a transdermal absorption technology. The method is characterized by comprising thefollowing steps: (1) gel paste is prepared, specifically, a cotton rose hibiscus leaf extract is weighed, crushed into fine powder, added into a Carbomer solution containing EDTA and evenly mixed, sodium polyacrylate and a dihydroxyaluminum aminoacetate and glycerinum mixed solution are added, even stirring is conducted, an appropriate quantity of citric acid solution is added, even stirring is conducted, and cotton rose hibiscus leaf extract gel is obtained; and (2) a transdermal absorption experiment of the cotton rose hibiscus leaf extract is conducted, specifically, pig skin is pre-treatedand then serves as a transdermal barrier, ethanol-normal saline serves as transdermal absorption fluid, the gel is smeared on treated pig skin corneum, the transdermal absorption fluid is fully injected, the liquid level is exactly in contact with a skin corium layer, bubbles are eliminated, the transdermal absorption experiment is conducted, and transdermal liquid is obtained.

The invention discloses an eyesight improving and eye nourishing eye patch composition, which comprises the following raw materials by weight: 15-25 parts of the extract of flickingeria comata (bl.) hawkes, 10-20 parts of the extract of saussurea involucrata, 5-15 parts of the extract of crocus sativus l, 20-30 parts of a wild chrysanthemum extract, 5-10 parts of pearl powder, 5-15 parts of menthol, 10-15 parts of the extract of senecio scandens, 30-40 parts of borneol, 15-20 parts of dragonfly, and 10-15 parts of ant. According to the present invention, the eyesight improving and eye nourishing eye patch composition can provide effects of eyesight improving and eye nourishing, can provide significant effects on visual fatigue, eye swelling, xerophthalmia and other symptoms caused by overuse of eyes, has effects of blood circulation activation, meridian promoting, inflammation eliminating, itching stopping, pain stopping, eyesight improving and beautifying, and can supplement and maintain the moisture in eye skin, promote the blood circulation at eye parts, and enhance metabolism.