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Resveratrol nano-micelle and preparation method thereof

A technology of resveratrol and nano-micelle, which is applied in the preparation of the nano-micelle and the field of resveratrol nano-micelle preparation, can solve the problem of affecting the preservation of resveratrol, affecting the biological efficacy of resveratrol, etc. question

Inactive Publication Date: 2018-05-08
湖北爱济莱斯生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It affects the preservation of resveratrol, which in turn affects the biological efficacy of resveratrol

Method used

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  • Resveratrol nano-micelle and preparation method thereof
  • Resveratrol nano-micelle and preparation method thereof
  • Resveratrol nano-micelle and preparation method thereof

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Embodiment 1

[0025] Embodiment 1 Resveratrol nano-micelle preparation preparation process parameter selection

[0026] 1.1 Selection of carrier material

[0027] The invention selects poloxamer F-127 as a carrier material to prepare resveratrol nano micelles.

[0028] Poloxamer F-127 is a polyoxyethylene-polyoxypropylene ether block copolymer. It is a new type of non-ionic surfactant with typical amphiphilicity. Poloxamer F-127 is synthesized in medicine One of the new excipients is a high-molecular non-ionic surfactant, which is easily soluble in water and various organic solvents.

[0029] Therefore, choosing poloxamer F-127 as the carrier can not only increase the water solubility of resveratrol, but also improve the stability of resveratrol after being encapsulated by the carrier.

[0030] 1.2 Selection of preparation method

[0031] During the formation of drug-loaded polymer micelles, drugs can be embedded in three ways: physical, chemical, and electrostatic interactions. Since t...

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PUM

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Abstract

The invention discloses a resveratrol nano-micelle and a preparation method thereof. In order to determine an optimal raw material ratio and various preparation process parameters, a large number of experiments are conducted, and process parameters with a high encapsulation rate are obtained. The physicochemical properties and biological activity of the prepared resveratrol nano-micelle are studied through various experiments. Experiments show that the prepared resveratrol nano-micelle can significantly improve the stability of resveratrol and is high in transdermal absorption rate; pharmacodynamic experiments show that the prepared resveratrol nano-micelle is high in free radical scavenging rate and has a great tyrosine inhibiting effect.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, in particular to a resveratrol nano-micelle preparation. The present invention also relates to a preparation method of the nano-micelle. Background technique: [0002] Resveratrol (Resveratrol, Res) is a non-flavonoid phenolic substance that has many beneficial effects on the human body, such as protecting the liver, anti-inflammatory, anti-allergic, anti-pathogenic microorganisms, anti-cardiovascular, anti-tumor, etc. biological effect. [0003] Domestic and foreign studies have shown that the stability of resveratrol in brown bottles kept away from light is better than natural conditions, suggesting that resveratrol decomposes when exposed to light and is unstable. It affects the preservation of resveratrol, which in turn affects the biological efficacy of resveratrol. Therefore, how to improve the stability and curative effect of resveratrol has become an urgent problem to be solved in the d...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/10A61K31/05A61P39/06A61P35/00
CPCA61K9/1075A61K31/05A61K47/10
Inventor 郝新才李东升杨玉方
Owner 湖北爱济莱斯生物科技有限公司
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