The invention relates to a cyclosporine A
micelle eye drop and a preparing method thereof. The cyclosporine A
micelle eye drop comprises cyclosporine A used as a main
drug, aseptic and isoosmotic adjusting agents, and is characterized by further comprising a
copolymer of polythene
caprolactam,
polyvinyl acetate and
polyethylene glycol used as
drug auxiliary materials. The preparing method includes: preparing a cyclosporine A
micelle through a
solvent rotary
evaporation film forming method; obtaining cyclosporine A micelle
powder after filtering, freezing and
drying the cyclosporine A micelle; and dispersing and dissolving the
powder into a
buffer solution to obtain the cyclosporine A micelle
eye drop. According to the cyclosporine A micelle eye drop, the cyclosporine A has good
solubility in a water solution, the micelle is small in particle
diameter and uniform in distribution range and
drug stability is good. The cyclosporine A micelle eye drop not only reduces drug
irritation, but also improves drug absorption of a
cornea, reduces
drug concentration, prolongs
drug action time, reduces
dosing frequency, improves
patient compliance, and has good economical efficiency.