Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated
disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a
litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse
myocarditis was present in one piglet associated with extensive immunohistochemical
staining for PCV-2
antigen. Variable amounts of PCV-2
antigen were also present in liver,
lung and
kidney of multiple fetuses.
Inoculation of female pigs with a composition including an
immunogen from PCV-2 or an
epitope of interest from such an
immunogen or with a vector expressing such an
immunogen or
epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the
perinatal period, or repeatedly over a lifetime, or during
pregnancy, such as between the 6th and 8th and / or the 10th and 13th weeks of
gestation, can prevent
myocarditis,
abortion and intrauterine infection associated with
porcine circovirus-2. In addition, innoculation of male and / or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from
male to female (or vice versa) during
mating. Thus, the invention involves methods and compositions for preventing
myocarditis,
abortion and intrauterine infection associated with
porcine circovirus-2.