87results about How to "Good pH sensitivity" patented technology

The invention relates to a pH-sensitive hydrogel and a preparation method thereof. The hydrogel is composed of carboxymethyl chitosan, polymethyl vinyl ether, crosslinking agent glutaraldehyde and water, wherein the molar ratio of carboxymethyl chitosan to polymethyl vinyl ether is 1:0.25 ~1.5; the molar ratio of crosslinking agent glutaraldehyde and carboxymethyl chitosan is 1:10~30, and the balance is water. The preparation method of the hydrogel is as follows: under stirring, carboxymethyl chitosan and polymethyl vinyl ether are dissolved in deionized water at a molar ratio of 1:0.25 to 1.5, and fully mixed, while controlling the carboxymethyl chitosan and polymethyl vinyl ether. The concentration of methyl chitosan and polymethyl vinyl ether is in the range of 0.05 ~ 0.1M; then add pentamethylene glycol dropwise to the above mixed solution according to the molar ratio of carboxymethyl chitosan to 1:10 ~ 30 The aldehyde was stirred and reacted for 30 to 60 minutes, then poured into the mold after standing still, and dried at room temperature to a constant weight to obtain a semi-interpenetrating network pH-sensitive hydrogel. The hydrogel obtained by the invention not only has good pH sensitivity, but the addition of PVME improves the shortcoming of CMCS being hard and brittle, so that the obtained material has high adhesion and softness, and this hydrogel can be degraded under certain conditions , as a sustained-release drug carrier has potential application value.