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Process for preparing rapidly responsive pH sensitive hydrogel

A fast-response, hydrogel technology, which is applied in the field of pH-sensitive hydrogel polymer material preparation, can solve the problems of easy residue and difficult removal of porogens, and achieve good biocompatibility and simple polymerization process Effect

Inactive Publication Date: 2005-08-17
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the disadvantage of this method is that the porogen is easy to remain in the hydrogel and it is difficult to completely remove it, which cannot meet the needs in some occasions with strict requirements on the hydrogel

Method used

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  • Process for preparing rapidly responsive pH sensitive hydrogel
  • Process for preparing rapidly responsive pH sensitive hydrogel
  • Process for preparing rapidly responsive pH sensitive hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 5.3g sulfadiazine is dissolved in the aqueous solution and the acetone solution of the mass concentration 2%NaOH that volume ratio is 1: 1, pours in the four-neck flask that agitator, condensing tube and thermometer are housed, stirs at constant speed, and with ice-water bath Cool to keep the reaction temperature below 5°C. After the temperature is constant, gradually add 2g of acryloyl chloride dropwise, keep the temperature below 10°C for 1-3 hours, stop the experiment, and discharge. The precipitated product was filtered and washed three times with distilled water to remove unreacted monomer impurities to obtain a milky yellow solid, which was vacuum-dried at room temperature for 24 h to obtain a yellow powder.

[0028] 0.366g N-vinylpyrrolidone monomer, 0.534g sulfonamide monomer, 0.009g crosslinking agent N, N-methylenebisacrylamide, 0.0096g initiator azobisisobutyronitrile were dissolved in 5ml dimethyl sulfoxide, After stirring evenly, quickly pour it into a test...

Embodiment 2

[0029] Embodiment 2: Dissolve 0.366g N-vinylpyrrolidone monomer, 0.534g sulfonamide monomer, 0.018g crosslinking agent N, N-methylenebisacrylamide, 0.0096g initiator azobisisobutyronitrile in Example 1 5ml of dimethyl sulfoxide, stirred evenly and quickly poured into a test tube with a diameter of 20cm. After sealing the test tube, put it into a water bath whose temperature was previously controlled at 65° C. for constant temperature heating reaction for 10 h. After the reaction, the prepared sensitive hydrogel was taken out of the test tube, soaked in deionized water for 24 hours, washed thoroughly to remove impurities such as unreacted monomers, cross-linking agents and solvents, and dried in a vacuum oven for 3-5 hours. days to obtain the prepared hydrogels.

Embodiment 3

[0030] Embodiment 3: Dissolve 0.366g N-vinylpyrrolidone monomer, 0.534g sulfonamide monomer, 0.036g crosslinking agent N, N-methylenebisacrylamide, 0.0096g initiator azobisisobutyronitrile in Example 1 5ml of dimethyl sulfoxide, stirred evenly and quickly poured into a test tube with a diameter of 20cm. After the test tube was sealed, it was put into a water bath whose temperature was previously controlled at 65° C. for a constant temperature heating reaction for 6 h. After the reaction, the prepared sensitive hydrogel was taken out of the test tube, soaked in deionized water for 24 hours, washed thoroughly to remove impurities such as unreacted monomers, cross-linking agents and solvents, and dried in a vacuum oven for 3-5 hours. days to obtain the prepared hydrogels.

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Abstract

The present invention is the preparation process of fast responding pH sensitive hydrogel, and belongs to the field of polymer material preparing technology. The preparation process of the hydrogel includes the following steps: dissolving sulfadiazine in alkali aqua and acetone solution, dripping acrylyl chloride to react, filtering the product, washing to eliminate unreacted monomer and impurity and drying to obtain sulfadiazine monomer; mixing N-vinylpyrrolidone, sulfadiazine monomer, 1N, N-methylene diacrylamide, azodiisobutyronitrile and dimethyl sulfoxide to form mixed solution and react in water bath at 30-100 deg.c for 2-24 hr to obtain hydrogel; soaking and washing with deionized water to eliminating unreacted monomer, cross-linking agent and solvent impurity, and drying to obtain the pH sensitive hydrogel. The prepared pH sensitive hydrogel is especially sensitive in pH 6.8-7.2, and is expected to prepare medicine release controlling supplementary material.

Description

technical field [0001] The invention relates to a preparation method of a fast-response pH-sensitive hydrogel, which belongs to the preparation technology of a pH-sensitive hydrogel polymer material. Background technique [0002] Hydrogel is a commonly used carrier material for controlled release of drugs. Synthetic hydrogels commonly used in the biomedical field include polymethacrylates, polyvinylpyrrolidones, polyvinyl alcohols, and polyethylene glycols. In recent years, N-vinylpyrrolidone (NVP) has appeared in a large number in the research of polymers. NVP based on lactam compounds contains a five-membered ring of N atoms in the structure, and a vinyl group is attached to the N atom. Make NVP easy to polymerize and hydrolyze in nature. Polymers synthesized by polymerization reaction of NVP as a monomer have some unique properties. Poly N-vinylpyrrolidone (PVP) is a typical example of the successful application of NVP. Especially because the molecular structure of PVP ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F226/10C08J3/075
Inventor 郭锦棠李伶朱军利
Owner TIANJIN UNIV
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