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Modified succinyl chitosan hydrogel as well as preparation method and application thereof

A technology of succinyl chitosan water and succinyl chitosan, which is applied in the field of modified succinyl chitosan hydrogel and its preparation, can solve the problems of insufficient safety of the cross-linking system and insufficient functional properties such as antibacterial, and achieve excellent The effect of functional characteristics, flexible and controllable performance, and simple operation

Active Publication Date: 2019-01-08
深圳市优聚新能源科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of insufficient functional properties such as antibacterial and unsafe crosslinking systems in the existing hydrogel materials, and provide a modified succinyl chitosan hydrogel material, which not only has outstanding swelling ability and pH sensitivity, but also has excellent antibacterial properties, the cross-linking agent used in the preparation process is not only non-toxic but also has good biocompatibility

Method used

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  • Modified succinyl chitosan hydrogel as well as preparation method and application thereof
  • Modified succinyl chitosan hydrogel as well as preparation method and application thereof
  • Modified succinyl chitosan hydrogel as well as preparation method and application thereof

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Embodiment 1

[0030] Such as figure 1 Shown, a kind of preparation method of modified succinyl chitosan hydrogel is specifically as follows:

[0031] (1) Take 0.80g of succinochitosan and dissolve it in distilled water, and stir it with magnetic force to make it dissolve completely. Another certain amount of 2.0 generation polyamide-amine dendrimers was taken, and the pH was adjusted to 7 with dilute hydrochloric acid to obtain a polyamide-amine dendrimer solution. The two solutions were mixed according to the mass ratio of 2.0-generation polyamidoamine dendrimers to succinyl chitosan at 1:9, and magnetically stirred for 30 minutes until they were evenly mixed. The concentration of succinyl chitosan in the resulting mixed solution is 40g L -1 .

[0032] (2) Add crosslinking agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to the above mixed solution and stir evenly. Wherein, the molar ratio of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydr...

Embodiment 2

[0036] A kind of preparation method of modified succinyl chitosan hydrogel is specifically as follows:

[0037] (1) Take 0.80g of succinochitosan and dissolve it in distilled water, and stir it with magnetic force to make it dissolve completely. Another certain amount of 2.0 generation polyamide-amine dendrimers was taken, and the pH was adjusted to 7 with dilute hydrochloric acid to obtain a polyamide-amine dendrimer solution. The two solutions were mixed according to the mass ratio of 2.0 generation polyamidoamine dendrimers to succinyl chitosan 5:5, and magnetically stirred for 30 minutes until the mixture was uniform. The concentration of succinyl chitosan in the resulting mixed solution is 40g L -1 .

[0038] (2) Add crosslinking agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to the above mixed solution and stir evenly. Wherein, the molar ratio of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride to succinyl chito...

Embodiment 3

[0042] A kind of preparation method of modified succinyl chitosan hydrogel is specifically as follows:

[0043] (1) Take 0.80g of succinochitosan and dissolve it in distilled water, and stir it with magnetic force to make it dissolve completely. Another certain amount of 2.0 generation polyamide-amine dendrimers was taken, and the pH was adjusted to 7 with dilute hydrochloric acid to obtain a polyamide-amine dendrimer solution. The two solutions were mixed according to the mass ratio of 2.0 generation polyamidoamine dendrimers to succinyl chitosan 5:5, and magnetically stirred for 30 minutes until the mixture was uniform. The concentration of succinyl chitosan in the resulting mixed solution is 40g L -1 .

[0044] (2) Add crosslinking agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide to the above mixed solution and stir evenly. Wherein, the molar ratio of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride to succinyl chito...

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Abstract

The invention relates to a modified succinyl chitosan hydrogel as well as a preparation method and the application thereof, and mainly solves problems that an ordinary hydrogel material is insufficient in antibacterial and other functional properties and not safe enough in crosslinking system. According to the modified succinyl chitosan hydrogel provided by the invention, non-toxic and biocompatible 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are used as cross-linking agents; and succinyl chitosan and 2.0-generation polyamide-amine dendrimer are subjected to cross-linking reaction to obtain hydrogel with a novel crosslinked net structure. The hydrogel not only has an outstanding swelling property and pH sensitivity, but also has an excellent antibacterial property, and has a good application potential in the field of biomedical materials.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a modified succinyl chitosan hydrogel and a preparation method and application thereof. Background technique [0002] Hydrogel is a cross-linked polymer material that can swell but not dissolve. It has many potential applications in the fields of chemical industry, food and biomedical materials, such as adsorbents, wound dressings and drug sustained and controlled release carriers. . In recent years, research on hydrogels as wound dressings has attracted increasing attention. This is because the cross-linked three-dimensional network structure of the hydrogel can absorb a large amount of water. When it comes into contact with the wound, it can provide a moist wound environment and promote the proliferation and growth of tissue cells, thereby helping to speed up the repair of the wound. However, traditional hydrogel wound dressings suffer from insufficient antibacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08L79/02C08J3/075C08J3/24
CPCC08J3/075C08J3/246C08J2305/08C08J2479/02
Inventor 江靖何广华陈想王程曹继龙
Owner 深圳市优聚新能源科技有限公司
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