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Preparation method and application of silver nanocluster

A silver nanocluster, aqueous solution technology, applied in nanotechnology, chemical instruments and methods, fluorescence/phosphorescence, etc., can solve the problems of unsatisfactory purification effect, time-consuming, complicated purification, etc., and achieves wide and cheap sources of materials and simple and easy preparation methods. good reproducibility

Inactive Publication Date: 2016-07-27
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods are relatively complicated to purify, time-consuming, and the purification effect is not ideal.

Method used

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Examples

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Effect test

preparation example Construction

[0012] On the one hand, the present invention provides a kind of preparation method of silver nanocluster, it is characterized in that: it comprises the following steps:

[0013] Step 1, preparing an aqueous solution of bovine serum albumin or lipoic acid;

[0014] Step 2, add soluble silver salt to the aqueous solution of step 1, mix well, then add soluble BH 4 - Salt solution, stirring to obtain a silver nanocluster stock solution;

[0015] Step 3, adding an acid solution to the silver nanocluster stock solution obtained in step 2, until the pH value is 3-6, to obtain silver nanocluster precipitation;

[0016] In step 4, the silver nano-cluster precipitate obtained in step 3 is centrifuged, separated, washed with water, and then redispersed in an alkaline solution with a pH value of 9-12.

[0017] Preferably, in step 1, the aqueous solution of lipoic acid is prepared, and step 5 is also included, adding soluble BH to the dispersion in step 4 4 - Salt solution, stirred t...

Embodiment 1

[0028] (1) dissolving bovine serum albumin in an aqueous solution to form a clear and transparent solution;

[0029] (2) AgNO 3 Add in the solution, mix well, form mixed material, wherein, every 1 mass part of Ag + Correspondingly add bovine serum albumin of 30 parts by mass;

[0030] (3) under stirring, slowly add sodium hydroxide solution and sodium borohydride dropwise, and continue to stir for 6 hours to obtain a silver nanocluster stock solution, wherein, every 1 mole fraction of Ag + Corresponding to the addition of 0.2 mole fraction of BH 4 - ;

[0031] (4) Add 0.1MHAc to the stock solution to adjust the pH of the silver nanocluster stock solution to 3-6 to promote the generation of silver nanocluster precipitation;

[0032] (5) The silver nanocluster precipitate is centrifuged at a rotating speed of 10000-12000 rpm, separated, and then the precipitate is washed 3 times with 5-10 mL of deionized water;

[0033] (6) redispersing the washed precipitate in an alkalin...

Embodiment 2

[0037] (1) dissolving bovine serum albumin in an aqueous solution to form a clear and transparent solution;

[0038] (2) AgNO 3 Add in the solution, mix well, form mixed material, wherein, every 1 mass part of Ag + Correspondingly add the bovine serum albumin of 26 mass parts;

[0039] (3) under stirring, slowly add sodium hydroxide solution and sodium borohydride dropwise, and continue to stir for 6 hours to obtain a silver nanocluster stock solution, wherein, every 1 mole fraction of Ag + Corresponding to the addition of 0.1 mole fraction of BH 4 - ;

[0040] (4) Add 0.5MHAc to the stock solution to adjust the pH of the silver nanocluster stock solution to 3-6 to promote the generation of silver nanocluster precipitation;

[0041] (5) The silver nanocluster precipitate is centrifuged at a rotating speed of 10000-12000 rpm, separated, and then the precipitate is washed 3 times with 5-10 mL of deionized water;

[0042] (6) redispersing the washed precipitate in an alkali...

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PUM

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Abstract

The invention provides a preparation method of a silver nanocluster. The prepared silver nanocluster has high purity and high fluorescence intensity, and is uniform and good in reproducibility. The preparation method is simple, feasible and fast. Raw materials are wide in source and low in price, the preparation process is free of pollution, and the preparation method can be used for large-scale industrialized production. The prepared silver nanocluster is sensitive to the pH value, the fluorescence intensity is enhanced along with the increase of pH, and it is shown that the silver nanocluster can be used as a fluorescence switch to indicate pH changes in a system.

Description

technical field [0001] The invention relates to the synthesis technology of silver nano-clusters, in particular to a preparation method and application of silver nano-clusters. Background technique [0002] In recent years, the synthesis of water-soluble fluorescent metal nanoclusters using various template molecules and stabilizers such as proteins, DNA, and thiols as raw materials has become a research hotspot. During the synthesis process, a large number of template molecules and stabilizers need to be used, and these molecules may react with many analytes, thus causing great trouble to subsequent detection. Moreover, the inner filter effect of the synthetic raw materials will also reduce the fluorescence of the synthesized clusters. Therefore, the purification of water-soluble nanoclusters has become the focus of current work. As far as we know, three methods are currently used to purify nanoclusters: dialysis, ultrafiltration and chromatographic separation techniques....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B82Y40/00G01N21/64C09K11/58
CPCB22F9/24B82Y40/00C09K11/58G01N21/64
Inventor 熊华玉王薇王升富张修华文为郑慧铃
Owner HUBEI UNIV
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