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Comprehensive extraction technology of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid

A technology of rosmarinic acid and oleanolic acid, which is applied in the separation/purification of carboxylic acid esters, the separation/purification of carboxylic acid compounds, and the preparation of carboxylic acid esters, and can solve the problems of many chemical residues, poor chroma, Low extraction rate and other problems, to achieve the effect of simple process and convenient operation

Inactive Publication Date: 2015-03-25
付大亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method solves the problems of large amount of extraction solvent, many chemical residues, poor color and low extraction rate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The composite extraction process of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid comprises the following steps:

[0022] (1) Raw material pretreatment: put the rosemary into a steam tank after being pulverized, and steam to separate the essential oil;

[0023] (2) reflux alcohol extraction: the rosemary after step (1) is processed is extracted three times with ethanol heat reflux, and the ethanol consumption is respectively 8-5, 6-4, 5-3 times of raw material quality, each extraction time 1-3h;

[0024] (3) Primary separation: combine three extracts, recover ethanol by distillation under reduced pressure, and add water to catch the alcohol to ensure that the amount of the extract is not less than 4 times the quality of the raw material. After the ethanol is completely recovered, place it for cooling, centrifuge, and collect the centrifuged supernatant respectively and centrifugal sedimentation;

[0025] (4) Separation of rosmarinic acid: the centrif...

Embodiment 2

[0029] The composite extraction process of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid comprises the following steps:

[0030] (1) Raw material pretreatment: put the rosemary into a steam tank after being pulverized, and steam to separate the essential oil;

[0031] (2) reflux alcohol extraction: the rosemary treated in step (1) is extracted three times with ethanol heat reflux, the amount of ethanol is respectively 8, 6, and 5 times of the raw material quality, and each extraction time is 3h;

[0032] (3) Primary separation: combine three extracts, recover ethanol by distillation under reduced pressure, and add water to catch the alcohol to ensure that the amount of the extract is not less than 4 times the quality of the raw material. After the ethanol is completely recovered, place it for cooling, centrifuge, and collect the centrifuged supernatant respectively and centrifugal sedimentation;

[0033] (4) Separation of rosmarinic acid: the centrifuged sup...

Embodiment 3

[0037] The composite extraction process of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid comprises the following steps:

[0038] (1) Raw material pretreatment: put the rosemary into a steam tank after being pulverized, and steam to separate the essential oil;

[0039] (2) reflux alcohol extraction: the rosemary treated in step (1) is extracted three times with ethanol heat reflux, the amount of ethanol is respectively 5, 4, and 3 times of the raw material quality, and each extraction time is 1h;

[0040] (3) Primary separation: combine three extracts, recover ethanol by distillation under reduced pressure, and add water to catch the alcohol to ensure that the amount of the extract is not less than 4 times the quality of the raw material. After the ethanol is completely recovered, place it for cooling, centrifuge, and collect the centrifuged supernatant respectively and centrifugal sedimentation;

[0041] (4) Separation of rosmarinic acid: the centrifuged sup...

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PUM

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Abstract

The invention discloses a comprehensive extraction technology of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid. The comprehensive extraction technology comprises the steps of (1) preprocessing raw materials; (2) performing reflux alcohol-extraction; (3) carrying out primary separation; (4) separating out rosmarinic acid; (5) separating out ursolic acid; (6) separating out oleanolic acid. According to the comprehensive extraction technology, the process is simple, the operation is convenient, industrial production can be easily carried out, and meanwhile, the purpose of synchronously extracting rosmarinic acid of rosemary, ursolic acid, oleanolic acid and carnosic acid is achieved, and the active ingredients of rosemary can be extracted to the maximum; the rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid respectively have the purity exceeding 30%, 25%, 20% and 25%.

Description

technical field [0001] The invention belongs to the technical field of extraction of plant active components, and in particular relates to a composite extraction process of rosmarinic acid, ursolic acid, oleanolic acid and carnosic acid. technical background [0002] Rosemary (Rosmarinus officinalis) is a labiatae shrub, the English name is Rosemary, native to the Mediterranean Basin, northwestern Spain and Portugal. The stems, leaves, and flowers of rosemary have a strong aroma, which can refresh the mind, enhance memory, and promote blood circulation. It has therapeutic effects on nervous, digestive, and respiratory diseases; when epidemics break out in Europe, they are often burned in hospitals To sterilize and purify the air; the Moors believed that rosemary could drive away pests, so rosemary was planted in large quantities around the orchard. It can be seen from the above that people have a long history of developing and utilizing rosemary. Modern studies have shown ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48C07J63/00C07C62/32C07C51/42
CPCC07C67/58C07C51/44C07C51/47C07C51/48C07C67/54C07C67/56C07C2603/26C07J63/008C07C69/732C07C62/32
Inventor 付大亮付泽付雅琴秦超群王定邦
Owner 付大亮
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