Rare ginsenoside composition including rare protopanaxatriol (PPT)

A technology of protopanaxatriol and ginsenoside, applied in the field of biomedicine

Inactive Publication Date: 2016-12-21
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there is no report on how to combine ginsenosides on the basis of single components to enhance their antitumor effects and prepare highly efficient and low-toxic antitumor drugs.

Method used

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  • Rare ginsenoside composition including rare protopanaxatriol (PPT)
  • Rare ginsenoside composition including rare protopanaxatriol (PPT)
  • Rare ginsenoside composition including rare protopanaxatriol (PPT)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Ginsenoside Gum PPT Capsules

[0050] Make tablets according to the following ratio (10000 tablets, PPT content: 50mg / tablet)

[0051]

[0052] The main process flow is as follows: Pour the weighed cornstarch, protopanaxatriol (PPT), citric acid, sodium carboxymethyl cellulose, microcrystalline cellulose, and talc into the high-speed mixing granulator in sequence, and the operator Operate in accordance with the equipment operating procedures and post operating procedures, rotate at 550 rpm, stir for 10 minutes to make it evenly mixed, then add an appropriate amount of 90% ethanol, continue to stir for 5 minutes until evenly mixed, and granulate to obtain wet granules. Pour the granules into the container and evenly spread them on the plate with a thickness of 3-5cm. Control it within the range of 50°C to 55°C, open the steam drain valve, drain the condensed water in the steam pipe first, then close it, open the steam outlet valve, open the steam inlet valv...

Embodiment 2

[0053] Embodiment 2 protopanaxatriol (PPT) tablet

[0054] Make tablets according to the following ratio (10000 tablets, PPT content: 50mg / tablet)

[0055]

[0056] The main process flow is as follows: Pour the weighed pregelatinized starch, protopanaxatriol (PPT), malic acid, magnesium stearate, cross-linked PVP, sodium carboxymethyl cellulose and microcrystalline cellulose into the high-speed In the mixing granulator, the operator operates in accordance with the equipment operating procedures and post operating procedures, the speed is 450rpm, stirring for 10 minutes to make it evenly mixed, then add an appropriate amount of 85% ethanol, continue to stir for 5 minutes until the mixing is even, and granulate to obtain wet granules . Pour the granules into the container and evenly spread them on the plate with a thickness of 3-5cm. Control it within the range of 45°C to 50°C, open the steam drain valve, drain the condensed water in the steam pipe first, then close it, ope...

Embodiment 3

[0057] Embodiment 3 protopanaxatriol (PPT) dropping pill

[0058] Make tablets according to the following ratio (10000 pills, PPT content: 5mg / pill)

[0059]

[0060] The main process flow is as follows: keep the room temperature in the operation room at 18°C-25°C, and the relative humidity at 20%-40%. The temperature of the melting tank is 145°C-150°C. After the polyethylene glycol-6000 is melted into a clear liquid, pour protopanaxatriol (PPT) and oxalic acid into it, stir until they are completely dissolved, and put the material into the storage tank. The temperature of the material storage tank is 100°C-110°C, and the temperature of the internal liquid medicine is kept at 90°C-100°C, and the material is discharged into the drop material tank. The temperature of the dripping tank is 100°C-110°C, the temperature of the cooling oil is 5°C-10°C, and the weight of the pills is controlled by the machine to be 22-24mg. After the dripped vegetarian pills are deoiled, the pill...

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PUM

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Abstract

The invention provides a rare ginsenoside composition including rare PPT. The rare ginsenoside composition comprises rare PPT and edible C2-6 organic dicarboxylic acid or tricarboxylic acid, wherein the edible C2-6 organic dicarboxylic acid or tricarboxylic acid accounts for 0.05 to 5 parts by weight on the basis of 100 parts by weight of PPT. The rare ginsenoside composition has substantial antineoplastic activity and has high efficiency and low toxicity.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a rare ginsenoside composition containing rare protopanaxatriol (PPT), which has antitumor activity, high efficiency and low toxicity. Background technique [0002] Cancer is the second most threatening human disease after cerebrovascular disease. The incidence of cancer in my country exceeds 3 million people every year, and the incidence of lung cancer, breast cancer, and esophageal cancer increases year by year, among which the annual growth rate of lung cancer incidence is 26.8%, and the annual growth rate of breast cancer incidence is 6.8%. Over the past 30 years, the mortality rate of breast cancer has increased by 96%, and the mortality rate of lung cancer has soared by 465%. my country's cancer prevention and control work is urgent and the situation is grim. [0003] However, there has not been any report on how to combine ginsenosides on the basis of single components to enhan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61K31/194A61P35/00
CPCA61K31/575A61K31/194A61K2300/00
Inventor 范代娣段志广马晓轩黄蓉范翠英刘彦楠严建亚
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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