Application of protopanaxadiol derivative and protopanaxatriol derivative in preparation of drugs

A technology of protopanaxadiol and protopanaxatriol, which is applied in the directions of drug delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of undisclosed neurodegenerative diseases use, etc., to improve space exploration and orientation capabilities, and broad development prospects Effect

Active Publication Date: 2014-08-06
SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

ZL200510016774.4 discloses the synthesis method of dammar-20S-24(S)-epoxy-3β, 12β, 25-triol and its application in the preparation and treatment of coronary heart disease, myocardial ischemia, ischemic shock, arrhythmia and Use in medicine for reperfusion injury, but does not disclose its use in the preparation of medicines for treating or preventing neurodegenerative diseases

Method used

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  • Application of protopanaxadiol derivative and protopanaxatriol derivative in preparation of drugs
  • Application of protopanaxadiol derivative and protopanaxatriol derivative in preparation of drugs
  • Application of protopanaxadiol derivative and protopanaxatriol derivative in preparation of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Add 10g of Damar-20S-24(R)-epoxy-3β,12β,25-triol, add 20g of lactose, mix well, use 70% ethanol as binder, granulate, put into capsules, and obtain capsules , Each capsule contains 20mg of 20(S)-protopanaxadiol derivative.

Embodiment 2

[0059] Add 10g Damar-20S-24(S)-epoxy-3β,6β,12β,25-tetraol, add 20g lactose, mix well, use 70% ethanol as binder, granulate, put into capsules, and get Capsules, each containing 20mg of 20(S)-protopanaxadiol derivative.

Embodiment 3

[0061] 10g Damar-20S-24(R)-epoxy-3β,12β,25-triol, add 20g lactose, mix well, use 70% ethanol as binder, granulate, dry, add 5g magnesium stearate , Compressed into tablets to obtain tablets, each containing 50 mg of 20(S)-protopanaxadiol derivatives.

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Abstract

The invention provides an application of a protopanaxadiol derivative and a protopanaxatriol derivative in the preparation of drugs for treating or preventing neurodegenerative diseases. Pharmacological experiment results show that the above derivatives have a stronger anti-oxidation protection effect than 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in H2O2 damage models of PC12 cells and N2a cells. Two vascular dementia models comprising a repeated occlusion rat bilateral vascular carotid cooperation sodium nitroprusside pressure reduction process stimulated dementia model and a bilateral hippocampus injection Abeta1-42 duplicated senile dementia model can improve the rat space exploration and orientation capability.

Description

technical field [0001] The invention relates to a panaxadiol compound, in particular to a new application of a 20(S)-protopanaxadiol derivative and a 20(S)-protopanaxatriol derivative in pharmacy. It belongs to the field of medicine. Background technique [0002] Neurodegenerative diseases (Degenerative diseases of the central nervous system, ND) are a group of chronic progressive neurological diseases based on primary neuron degeneration. Such diseases mainly include Alzheimer's disease (Alzheimer's disease, AD) (commonly known as senile dementia), Parkinson's disease (Parkinson's disease, PD), Huntington's chorea (Huntington disease), different types of spinocerebellar ataxia ( spinal cerebellar ataxias), amyotrophic lateral sclerosis (amyotrophic lateralsclerosis) and spinal muscular atrophy (spinal muscular atrophy), etc. [0003] Studies have found that ND is caused by a variety of different reasons, including insufficient nutrition provided by neurons or glial cells,...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P25/28A61P25/16
CPCA61K9/0019A61K9/08A61K9/1623A61K9/2018A61K31/58A61P25/16A61P25/28
Inventor 王记华卢寿福杨子荣
Owner SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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