Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and food or beverage

a technology of anemia and ameliorating agent, which is applied in the direction of drug compositions, extracellular fluid disorders, metabolic disorders, etc., can solve the problems of increased creatine kinase (cpk) level, deterioration of high blood pressure condition, and difficulty in selecting optimal diet restriction and exercise therapy methods, etc., to achieve excellent neutral fat level regulation, excellent anemia-ameliorating effect, and high safety

Inactive Publication Date: 2012-10-11
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0050]The present invention can provide: a neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent, an anti-obesity agent and a hyperlipemia-ameliorating agent, which have excellent neutral-fat-level-regulating effects, cholesterol-level-regulating effects, free-fatty-acid-level-regulating effects and anti-obesity effects and which are naturally occurring and highly safe and can be given as a food or beverage; an anemia-ameliorating composition which has excellent anemia-ameliorating effects and which is naturally occurring and highly safe and can be given

Problems solved by technology

In addition, arterial sclerosis deteriorates the condition of high blood pressure and causes kidney diseases and other diseases.
However, there is difficulty in selecting optimal methods for diet restriction and exercise therapy, and those receiving such therapies have to continuously and constantly address them.
This drug has cholesterol-regulating effects but problematically involves adverse side effects such as hepatic disorder, rhabdomyolysis, an increase in creatine kinase (CPK) level, diarrhea and stomachache.
These compounds, however, do not have satisfactory preventing and ameliorating effects on hyperlipemia.
These plants, however, do not have satisfactory effects.
In general, the total number of blood cells in blood, especially the number of hemoglobin, decreases with the progress of anemia, so that the ability to transport oxygen decreases to cause lack of oxygen in tissues.
However, in the method for ameliorating anemia by intake of foods, satisfactory effects cannot be expected without taking in iron-rich foods simultaneously with nutrients such as vitamins C, B6 and B12 and folic acid.
Among pharmaceutical drugs prescribed for anemia symptoms, Ferromia, F

Method used

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  • Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and food or beverage

Examples

Experimental program
Comparison scheme
Effect test

production example 1

Production of Hyperlipemia-Ameliorating Agent

[0164]5.9% by mass hydrochloric acid (6,666 mL) and 99.9% by mass aqueous ethanol solution (3,334 mL) were added to Panax notoginseng powder (1,000 g, product of MATSUURA YAKUGYO CO., LTD.) containing saponins such as ginsenoside-Rg1, notoginsenoside-R1, ginsenoside-Re, ginsenoside-Rb1, ginsenoside-Rd and ginsenoside-Rc. The resultant suspension was hydrolyzed with heating for 6 hours at 80° C. to prepare an aglycon-containing extract. Then, the pH of the aglycon-containing extract was adjusted to 6.7 with 6.6M aqueous sodium hydroxide solution to reduce the ethanol concentration, followed by suction filtration.

[0165]The residue was dried with heating under reduced pressure, to thereby obtain a strong acid-treated Panax notoginseng product containing aglycons.

example 1

Study on Hyperlipemia-Ameliorating Effects

—Preparation of Feed—

[0166]Protopanaxatriol (PPT) (product of Funakoshi Corporation), panaxatriol (PT) (product of Funakoshi Corporation), protopanaxadiol (PPD) (product of Funakoshi Corporation) and panaxadiol (PD) (product of Funakoshi Corporation) were each added to feed CE2 (product of CLEA Japan, Inc.) so that the concentration thereof was 0.05% by mass.

[0167]Similarly, the strong acid-treated Panax notoginseng product (Production Example 1) and Panax notoginseng powder (product of MATSUURA YAKUGYO CO., LTD.) were each added to feed CE2 (product of CLEA Japan, Inc.) so that the concentration thereof was 1.0% by mass.

[0168]Feed CE2 (product of CLEA Japan, Inc.) containing no other additives was used as feed for the control group.

—Intake—

[0169]Type 2-diabetes model mice KK-Ay / Ta Jc1 (male, 4 weeks old, 8 mice / group, product of CLEA Japan, Inc.) were preliminarily bred for 7 days. Thereafter, they were bred for 5 days with the above-prepar...

example 2-1

[0182]A capsule was charged with 1.0 g of crystalline cellulose containing 0.6% by mass of panaxadiol (product of LKT Laboratories, Inc.) and 1.4% by mass of panaxatriol (product of LKT Laboratories, Inc.) (the total amount of panaxadiol and panaxatriol: 20.0 mg) to prepare an anemia-ameliorating composition of Example 2-1.

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PUM

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Abstract

A neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent or an anti-obesity agent, including: at least one of protopanaxatriol, panaxatriol, protopanaxadiol and panaxadiol which are aglycons of dammarane-type saponins; and a hyperlipemia-ameliorating agent including: at least one of the neutral-fat-level-regulating agent, the cholesterol-level-regulating agent, the free-fatty-acid-level-regulating agent and the anti-obesity agent.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This is a continuation application of PCT / JP2010 / 067058, filed on Sep. 30, 2010.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a neutral-fat-level-regulating agent, a cholesterol-level-regulating agent, a free-fatty-acid-level-regulating agent, an anti-obesity agent and an anemia-ameliorating composition, each of which contains at least one of protopanaxatriol, panaxatriol, protopanaxadiol and panaxadiol.[0004]The present invention also relates to a hyperlipemia-ameliorating agent containing at least one of the neutral-fat-level-regulating agent, the cholesterol-level-regulating agent, the free-fatty-acid-level-regulating agent and the anti-obesity agent.[0005]The present invention also relates to a uric-acid-level-reducing composition containing residues obtained by treating plants belonging to the genus Panax of the family Araliaceae with an acid.[0006]The present invention also relates t...

Claims

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Application Information

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IPC IPC(8): A61K31/58C07J17/00A61P3/04A61P3/06A61P7/06A61P19/06C07J9/00A61K36/258
CPCC07J17/005A61K31/57C07J9/00C07J17/00A61K31/575A61K31/58A61P1/10A61P3/00A61P3/04A61P3/06A61P7/06A61P9/00A61P11/00A61P13/02A61P15/08A61P19/06A61P25/00A61P25/06A61P27/02A61P27/16A61P29/00A23L2/52A23V2002/00A23V2200/332A61K36/258A23L33/105
Inventor KAMBAYASHI, HIROAKIKITAMURA, KUMIKOIWASAKI, HIDEAKI
Owner LION CORP
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