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Application of saffron crocus pigment composition to preparation of medicine for treating or improving depressive disorder

A technology of saffron pigment and composition, which is applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., and can solve the problems of narrow antidepressant spectrum, toxic side effects, and easy relapse of chemical drugs

Inactive Publication Date: 2018-02-02
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of depression is mainly based on chemical drug therapy, but after long-term use, there will be serious side effects, and there are shortcomings such as narrow antidepressant spectrum of chemical drugs and easy relapse.

Method used

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  • Application of saffron crocus pigment composition to preparation of medicine for treating or improving depressive disorder
  • Application of saffron crocus pigment composition to preparation of medicine for treating or improving depressive disorder
  • Application of saffron crocus pigment composition to preparation of medicine for treating or improving depressive disorder

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Experimental program
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Effect test

preparation example Construction

[0037] Further, the preparation method of this type of saffron pigment composition comprises:

[0038] Step S1: using solvent extraction method to extract the fruit of Gardenia jasmine to obtain the total extract of Gardenia jasmine;

[0039] Wherein, the solvent extraction method includes any one or more of decoction method, heating reflux extraction method, ultrasonic vibration extraction method, percolation method and immersion method. The extraction solvent that solvent extraction method adopts is the alcoholic solution of 55~65Vol%, optional, is the ethanol or the methanol solution that is selected as 55~65Vol%; The volume fraction of alcohol in the alcoholic solution is 55~65Vol%, or is 58~ 62Vol%, or 60Vol%.

[0040] When the heating reflux extraction method is used for extraction, the ratio of solid to liquid (that is, the mass ratio of raw material to extraction solvent) is 1:3-5, or 1:4. A more preferred way is: heating and refluxing extraction with 4 times the amo...

Embodiment 1

[0049] Take 40.0 kg of dried and mature fruit of Gardenia jasminoides, after proper pulverization, heat and reflux extraction with 4 times the amount of 60 Vol% ethanol for 3 times, each time for 2 hours. The extracts were combined, and the solvent was evaporated under reduced pressure to obtain 6.2 kg of the total gardenia extract; the extract was dissolved in an appropriate amount of water, centrifuged, and subjected to macroporous resin open column chromatography (20.0 × 90 cm), followed by 4 times the volume of the column bed Water, 30Vol%, 50Vol%, 70Vol%, and 95Vol% ethanol were used for gradient elution, and the eluents of each part were collected, and the solvent was recovered under reduced pressure, respectively, to obtain about 4.5kg of water elution and 30Vol% ethanol elution combination, 50Vol % ethanol eluting part 710.0g, 70Vol% ethanol eluting part 150.0g, 95Vol% ethanol eluting part 112.0g, wherein, the ethanol eluting part of 70Vol% is gardenia saffron pigment c...

Embodiment 2

[0051] Efficacy test of gardenia saffron pigment composition in improving the symptoms of depression in mice induced by reserpine:

[0052] 1. Experimental plan:

[0053]ICR mice, male, weighing 22-25g, 175 were divided into 7 groups, 25 in each group, each group was control group, model group, fluoxetine (20mg / kg) group, GJ-4 (12.5mg / kg) kg) group, GJ-4 (25mg / kg) group, GJ-4 (50mg / kg) group, GJ-4 (100mg / kg) group. GJ-4 and the positive drug (fluoxetine) were intragastrically administered (the blank control group and the model group were intragastrically administered the same dose of CMC-Na), and 30 minutes later the intraperitoneal injection of reserpine (0.2mg / kg) (the blank control group The same dose of normal saline was injected intraperitoneally for 14 consecutive days, and body weight and food intake were monitored every day.

[0054] 2. Observation of degree of eyelid drooping

[0055] One hour after the last administration of reserpine, the mice were observed for t...

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Abstract

The invention provides the application of a saffron crocus pigment composition to the preparation of a medicine for treating or improving depressive disorder, and relates to the field of depressive disorder medicines. Through research findings, the saffron crocus pigment composition can obviously antagonize ptosis of upper eyelid of a mouse caused by reserpine, obviously improve the akinesis condition, obviously reduce the tail suspension immobility time and increase sweet water preference coefficient, so that the saffron crocus pigment composition has a good anti-depression effect, can improve various symptoms of the depressive disorder, serves as an anti-depression medicine and provides a new scheme for research and treatment on the depressive disorder.

Description

technical field [0001] The invention relates to the field of depression drugs, in particular to the application of a saffron pigment composition in the preparation of drugs for treating or improving depression. Background technique [0002] Depression is the main type of emotional disorders (mooddisorders), which is characterized by significant and persistent depression, decreased speech, slowness of spirit and action, etc., clinically manifested as a clinical syndrome of various physical symptoms and physiological dysfunction. Patients with severe illness even have suicide attempts and behaviors, and depression mostly shows as chronic recurrent attacks. The manifestations of depression are diverse, and the etiology and pathogenesis are complicated. Drug therapy is currently the main treatment method. [0003] With the accelerated pace of life, people's pressure is increasing, and the incidence of depression is showing an upward trend year by year. According to the statist...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P25/24
CPCA61K36/744A61K2236/333A61K2236/55
Inventor 姚新生张丹于洋鲍秀琦鲁丹臧彩霞盛婵娟
Owner JINAN UNIVERSITY
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