Anti-depression pharmaceutical composition
A technology of antidepressant and composition, applied in the field of preparation of the traditional Chinese medicine composition, to achieve the effect of clear drug effect
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Embodiment 1
[0020] Weigh 600g of Schisandra chinensis, heat and reflux extraction with 8 times the amount of 90% ethanol, extract three times, each time for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate into a thick paste. Weigh 360g Nardinus, extract the volatile oil by steam distillation, clathrate with β-cyclodextrin, and collect the distilled aqueous solution in another device. Combine the medicinal residues of Gansong with 600g Bupleuri and 360g licorice, add water to decoct three times, each time for 1 hour, filter, combine the filtrate, combine with the distilled aqueous solution, concentrate to a thick paste, and combine with the thick paste of Schisandra chinensis above, Dry, crush into fine powder, add volatile oil clathrate powder and mix, then add appropriate amount of soluble starch, mix well, dry to make granules.
Embodiment 2
[0022] Weigh 300g of Schisandra chinensis, heat and reflux extraction with 8 times the amount of 90% ethanol, extract three times, each time for 1 hour, filter, combine the filtrates, recover ethanol under reduced pressure and concentrate into a thick paste. Weigh 180g Nardinosa, extract the volatile oil by steam distillation, clathrate with β-cyclodextrin, and collect the distilled aqueous solution in another device. Combine the dregs of Gansong with 300g Bupleuri and 180g licorice, add water and decoct three times for 1 hour each time, filter, combine the filtrate, combine with the distilled aqueous solution, concentrate to a thick paste, and combine with the thick paste of Schisandra chinensis above, Drying, crushing into fine powder, adding volatile oil clathrate powder and mixing, then adding appropriate amount of soluble starch, mixing, drying to make granules, and packing into capsules to obtain capsules.
Embodiment 3
[0024] 1 material
[0025] 1.1 Experimental animals
[0026] 516 healthy Kunming mice, half male and half female, weighing 20±2g, were provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2012-0001.
[0027] 1.2 Reagents and medicines
[0028] 1.2.1 Pharmaceutical composition of the present invention
[0029] The granules prepared in Example 1.
[0030] 1.2.2 Schisandra extract
[0031] Schisandra chinensis was extracted three times with 90% ethanol under reflux, each time for 1 hour, filtered, combined filtrate, recovered ethanol under reduced pressure and concentrated to a thick paste, dried. Every 0.18g of schisandra alcohol extract is equivalent to 1g of schisandra medicinal material.
[0032] 1.2.3 Nardinus extract
[0033] Steam distilled pine nuts to extract the volatile oil, grind and clathrate with 6 times the amount of β-cyclodextrin; add 10 times the amount of water to the residue and decoct three times, 1 ...
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