Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

317 results about "Animal testing" patented technology

Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. This approach can be contrasted with field studies in which animals are observed in their natural environments or habitats. Experimental research with animals is usually conducted in universities, medical schools, pharmaceutical companies, defense establishments and commercial facilities that provide animal-testing services to industry. The focus of animal testing varies on a continuum from pure research, focusing on developing fundamental knowledge of an organism, to applied research, which may focus on answering some question of great practical importance, such as finding a cure for a disease. Examples of applied research include testing disease treatments, breeding, defense research and toxicology, including cosmetics testing. In education, animal testing is sometimes a component of biology or psychology courses. The practice is regulated to varying degrees in different countries.

Heteroaryl sulfonamides and CCR2

Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
Owner:CHEMOCENTRYX INC

Efficient and green diarrhea-preventing feed additive composite for weaned pigs

ActiveCN102228154AReduce usageAvoid the problem of drug resistance caused by abuseAnimal feeding stuffAccessory food factorsAnimal scienceAnimal testing
The invention discloses a feed additive composite for preventing weaned pigs from diarrhea. The feed additive composite comprises the following substances by mass: 30-40 parts of montmorillonite, 30-40 parts of organic acids and 20-30 parts of oligosaccharides. The feed additive composite has the following beneficial effects: the montmorillonite has high adsorbability and can serve as the sustained-release carrier of the oligosaccharides and acidulants in the digestive tracts of the animals, thus ensuring the oligosaccharides and acidulants to work in the whole intestinal tract, especially continuously playing roles in the hindgut; and the additive amount of the montmorillonite in the daily ration of the weaned pigs can be reduced through sterilization and bacteriostasis of the oligosaccharides and acidulants, thus avoiding the negative effects of the montmorillonite on palatability of the daily ration of the weaned pigs. The results of animal experiments show that the feed additive composite can effectively replace nano zinc oxide and part of feed antibiotics to be used in the daily ration of the weaned pigs, reduce the diarrhea rate of the weaned pigs and improve the survival rate and growth performance of the weaned pigs.
Owner:辽宁九州生物科技有限公司

One-bacterium multiple-enzyme bacterial strain as well as screening method and application thereof

The invention relates to a one-bacterium multiple-enzyme bacterial strain as well as a screening method and an application thereof. The bacterial strain is bacillus subtilis (Bacillus subtilis 1.1111) and is collected in the China center for type culture collection with the collection number of CCTCC (China center for type culture collection) No: M2011286. The bacillus subtilis (Bacillus subtilis 1.1111) can be used for preparing the bacterial strains of nine enzymes, i.e. xylanase, protease, phytase, pectinase, lipase, sweet dew glucanase, glucoamylase and the like, and the yields of the protease, the sweet dew glucanase, amylase and the glucoamylase are very high. Meanwhile, the bacterial strain is proved to have strong endurance capacity on cholate, artificial gastric juice and artificial intestinal juice by simulating the internal cholate environment, the artificial gastric juice, artificial intestinal juice and the animal test, safety and growth simulation capability are shown to a tested animal, and a foundation is laid for effectively improving the enzyme production capability of the bacterial strain, simultaneously generating the xylanase, the protease, the phytase, the pectinase, the lipase, the sweet dew glucanase and the glucoamylase and realizing one-bacterium multiple-enzyme fermentation in the fermentation process. The mutual synergistic effect among various enzymes generated by the bacterial strain is strong, and the bacterial strain can be used as a feed additive to be applied to agricultural production for livestock, fowls, aquatic livestock and the like.
Owner:HENAN UNIV OF SCI & TECH

Application of acetagastrodine in preparing medicines to prevent and treat vascular dementia (VD) and Alzheimer disease (AD)

Relating to the medicine field, the invention discloses the use of acetagastrodine in preparing medicines to prevent and treat vascular dementia and Alzheimer disease. The invention also provides a medicinal composition for preventing and treating senile dementia and its capsule as well as sustained release agent. Animal tests show that: acetagastrodine can substantially enhance the learning and memory abilities of rats with vascular dementia, reduce the activity of AchE in brains, enhance the vitality of ChAT in brains, and remarkably reduce Glu content; acetagastrodine has significant protective effect on damaged PC12 cells caused by H2O2 by enhancing the vitality of SOD and total ATP enzyme in PC12 cells and reducing the content of MDA and LD; acetagastrodine can substantially enhance the learning and memorizing abilities of AD model rats, enhance the CAT content in brains of the model rats, reduce the MAO vitality and simultaneously prevent the decrease of neurotransmitters. Acetagastrodine is better than gastrodin in terms of the treatment effects on VD and AD, and enjoys good clinical application prospect.
Owner:KPC PHARM INC

Production method of feed additive 'Acremonium terricola culture'

The invention discloses a production method of a feed additive 'Acremonium terricola culture'. The production method has the beneficial effects that by researching growth characteristics of Acremonium terricola strains and improving a production process of the Acremonium terricola culture, the production period of the Acremonium terricola culture is shortened from original 11-15 days to 5 days, the production cost of the Acremonium terricola culture is substantially lowered, and the production method has an important significance to the market promotion of the high-end feed additive; meanwhile, the energy loss of water, gas and electricity in the production process is greatly reduced. According to the production method, the production process of the Acremonium terricola culture mainly comprises the steps of 'liquid strain fermentation' and 'solid fermentation'. According to an animal test result, by utilizing the feed additive, the immunities of animals are improved, the feed conversion ratio is lowered, and the meat quality is improved. The production method has the advantages of low cost, short production period, controllability in control, good application effect and the like.
Owner:合肥河川生物医药科技有限公司

Brain-invigorating traditional Chinese medicine composite and preparation method and detection method thereof

The invention relates to a brain-invigorating traditional Chinese medicine composite and a preparation method thereof. The traditional Chinese medicine composite of the invention comprises the traditional Chinese medicine raw materials in parts by weight: 20-40 parts of Chinese angelica, 5-15 parts of Tabasheer, 15-35 parts of cistanche, 5-15 parts of dens draconis, 15-35 parts of Chinese yam, 5-15 parts of amber, 10-25 parts of Schisandra chinensis, 3-10 parts of gastrodia elata, 2-8 parts of semen boitae, 3-10 parts of Salvia miltiorrhiza, 10-25 parts of fructus alpiniae oxyphyllae, 3-10 parts of ginseng, 5-15 parts of polygala tenuifolia, 3-10 parts of chrysanthemum, 5-15 parts of Irkutsk Anemone Rhizome, 5-15 parts of ochre, 5-15 parts of arisaema cum bile, 35-60 parts of spina date seed and 15-30 parts of barbary wolfberry fruit. The invention also provides a detection method for the composite according to the components of the traditional Chinese medicine composite. The traditional Chinese medicine composite of the invention has good brain-invigorating effect. The animal testing proves that the traditional Chinese medicine composite of the invention has the functions of accelerating sleep, resisting fatigue and strengthening humoral immunity, can be used for invigorating brain, improving intellectual development, nourishing heart and soothing the nerves, and can be used for treating brain overstrain, fading memory, neurasthenia, light-headedness, fright insomnia, feeling of oppression over the chest, easy tiredness and Senile Dementia. The detection method has good ruggedness and high sensitivity.
Owner:SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD

Methods fo treating conditions associated with insulin resistance with aicar, (5-amino-4-imidazole carboxamide riboside) and related compounds

InactiveUS20030212014A1Positive impact in reducing obesityIncrease insulin sensitivityBiocideCompound screeningMammalDisease cause
The long-term usage of AICR (5-aminio, 4-imidazole carboxamide riboside) to produce sustained metabolic and biological changes in mammals that overcome insulin resistance, i.e., increase insulin sensitivity, and result in benefits in diseases and conditions such as diabetes, hypertension, atherosclerosis, polycystic ovary syndrome and gallstones is described long-term usage of AICAR, particularly intermittent administration, e.g., three days per week, appears to have some of the positive effects of exercise, having an impact on the amount Of food consumed by a subject and resulting in reduced fat build-up and increase in muscle mass. Therefore, AICAR administration has a positive impact in reducing obesity. AICAR can also Prove useful in preventing or treating vascular diseases associated with hyperglycemia, high plasma levels of free fatty acids (FFA) and triglyceride, and insulin resistance by virtue of the fact that this agent activates fatty acid oxidation. Animal tests have Shown that chronic intermittent treatment with AICAR has not resulted in any noticeable toxic effects. AICAR and related compounds are activators of AMP-activated protein kinase (AMPK) and, furthermore, are effective at decreasing malonyl CoA levels in the animal.
Owner:UNIV BOSTON TRUSTEES OF THE +1

Synthetic peptide vaccine and preparation method thereof

The invention provides aftosa synthetic peptide vaccine, more specifically to polypeptide or polypeptide polymer used for O type aftosa synthetic peptide vaccine, vaccine containing the polypeptide orpolypeptide polymer and a preparation method thereof. The polypeptide has amino acid sequence represented by SEQ ID NO.1, SEQ ID NO.2 or SEQ ID NO.3. By sequencing of recent aftosa strain in China an d combination of aftosa vaccine strain OS / 99 and OZK / 93 sequence, the invention researches variation case of main antigen site, carries out antigen site analysis and forecast assisted by computer, andcarries out chemical synthesis to possible antigen site peptide segment. The invention screens polypeptide antigen through a large amount of animal tests, optimizes aftosa virus antigen site accordin g to screening result, effectively combines T cell epitope and B cell epitope, and enhances immunization effect of the polypeptide antigen. The O type aftosa synthetic peptide vaccine can effectively reply antigenic variation of aftosa virus, has good biological safety, is easy for large scale production, and has better application prospect.
Owner:CHINA ANIMAL HUSBANDRY IND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products