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Application of catalpol in preparation of antidepressant medicine

An antidepressant and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2015-05-13
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, catalpol has not been reported in the preparation of drugs for the prevention and treatment of depression

Method used

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  • Application of catalpol in preparation of antidepressant medicine
  • Application of catalpol in preparation of antidepressant medicine
  • Application of catalpol in preparation of antidepressant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Catalpol antidepressant pharmacodynamics experiment

[0014] In the present invention, the mouse forced swimming test (Forced swimming test), the mouse tail suspension test (Tail suspension test) and the rat chronic mild unpredictable stress program (CUMS) are used to verify the antidepressant effect of catalpol.

[0015] 1.1 Experimental animals and administration

[0016] The experimental animals were healthy ICR mice (provided by Beijing Weitong Lihua Animal Experiment Center, certificate number: SCXK (Beijing) 2014-0003), male, 18-22 g; SD rats (provided by Beijing Weitong Lihua Animal Experiment Center) , certificate number: SCXK (Beijing) 2014-0012), male, 180-200 g, was bred in the Experimental Animal Center of Shanxi University, free drinking water and food were maintained during the experiment, the feeding environment temperature was 22±2°C, and adaptive feeding was 3-5 The experiment was carried out a few days later. The positive control drug was f...

Embodiment 2

[0044] The preparation of embodiment 2 capsules

[0045] Take an appropriate amount of 200g of catalpol, add 800g of starch, mix evenly, use 10% starch slurry to make soft material, pass through a 14-mesh sieve to granulate, dry at 70-80°C, granulate through a 16-mesh sieve, and put it into a hard gelatin capsule. That is, capsules are obtained.

Embodiment 3

[0046] The preparation of embodiment 3 tablet

[0047] Take 200g of catalpol, add 800g of starch, mix evenly, use 10% starch slurry to make soft material, granulate through a 14 mesh sieve, dry at 70-80°C, granulate with a 16 mesh sieve, add 3g of 0.5% magnesium stearate and mix Uniformly, compressed into tablets, coated with sugar, sub-packaged to obtain tablets.

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Abstract

The invention discloses application of catalpol in the preparation of an antidepressant medicine. The catalpol can be used as the antidepressant medicine for preventing and treating depression. A mouse forced swimming test (FST), a mouse tail suspension test (TST) and a rat chronic unpredictable mild stress (CUMS) test prove that the catalpol has an obvious antidepressant effect, the antidepressant activity of the catalpol reaches or exceeds that of the anti-depression western medicine fluoxetine commonly used in the clinic, and the catalpol can be used for preparing the medicine for preventing and treating depression.

Description

technical field [0001] The invention relates to an antidepressant drug, in particular to a new application of a natural compound catalpol. Background technique [0002] Depression is a kind of mood (emotional) disorder, which is mainly manifested as significant and persistent low mood. Mild cases are characterized by poor mood and lack of interest. Depression is a common mental disease that seriously endangers human physical and mental health. The World Health Organization has listed it as one of the top ten serious diseases. With the rapid development of social economy and the accelerated pace of life, people's pressure increases and various emotional impacts increase, resulting in an increase in the incidence of depression year by year. Depression has been dubbed the "epidemic of the 21st century". [0003] At present, the drugs for the treatment of depression mainly include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, monoam...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/24
Inventor 田俊生沈小丽张丽增秦雪梅
Owner SHANXI UNIV
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