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Application of patchouli alcohol to preparation of antidepressive medicine

A patchouliol and antidepressant technology, applied in the field of medicine, can solve the problems of slow onset of action and large side effects of antidepressant drugs, and achieve the effects of fast onset of action, no toxic and side effects, and good development value

Inactive Publication Date: 2019-08-02
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to overcome the defects and deficiencies such as large side effects and slow onset of existing antidepressant drugs, and to develop non-toxic and harmless antidepressant substances from natural medicines. The first research has found that the monomer compound patchouli alcohol has Significant antidepressant effect, and the effect is significantly better than fluoxetine, has a good development value

Method used

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  • Application of patchouli alcohol to preparation of antidepressive medicine
  • Application of patchouli alcohol to preparation of antidepressive medicine
  • Application of patchouli alcohol to preparation of antidepressive medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Experiment of antidepressant effect of patchouliol in vivo

[0036] 1. Experimental materials

[0037] 1.1 Experimental drugs

[0038] 1.1.1 Patchouli alcohol: self-made according to the method disclosed in the patent specification with publication number CN101485647A, and the purity is greater than 98%.

[0039] 1.1.2 Fluoxetine hydrochloride: purchased from Eli Lilly Suzhou Pharmaceutical Co., Ltd., sub-packaging batch number: S1628A.

[0040] 1.2 Experimental animals

[0041] 70 SD rats, SPF grade, all male, were purchased from Guangdong Provincial Laboratory Animal Center, animal qualification certificate: body weight 180-200g.

[0042] 2. Experimental method

[0043] 2.1 Drug preparation

[0044] 2.1.1 Preparation of patchouli alcohol solution: Weigh a certain amount of patchouli alcohol into a high-pressure bottle, add a certain amount of poloxamer as a co-solvent, heat and stir to dissolve, put it in a -20°C refrigerator overnight, scrape, Grind, ...

Embodiment 2

[0087] Embodiment 2 A kind of tablet for the treatment of depression

[0088] A tablet for the treatment of depression, which is formulated as follows:

[0089] Take 100-400 g of patchouli alcohol, add 380-580 g of lactose, an appropriate amount of starch and mix evenly, use 300-500 g of 7% starch slurry as a binder, wet granulate, dry, add 12-20 g of magnesium stearate and mix well , compressed into 10,000 tablets containing patchouli alcohol, each tablet has a net weight of 0.2g. Oral, used to treat depression. Practice has proved that the effect of antidepressant is good.

Embodiment 3

[0090] Embodiment 3 A kind of capsule for the treatment of depression

[0091] A capsule for treating depression is formulated as follows:

[0092] Take 100-400 g of patchouli alcohol, add 380-580 g of lactose, an appropriate amount of starch and mix evenly, use 300-500 g of 7% starch slurry as a binder, wet granulate, dry, add 12-20 g of magnesium stearate and mix well , filled to No. 1 capsule to make 10,000 capsules, each with a net weight of 0.2g. Oral, used to treat depression. Practice has proved that the effect of antidepressant is good.

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Abstract

The invention discloses application of patchouli alcohol to preparation of antidepressive medicine. The first research finds that the patchouli alcohol can effectively increase the parallel moving lattice number and the number of up-right times in a depression model rat open field experiment; the sweet water preference value in a depression model rat sweet water consumption experiment is increased; the motionless time in a depression model rat forced swimming experiment is reduced; an obvious anti-depression effect is achieved; the anti-depression effect is superior to that of fluoxetine; verygood development values are realized; the patchouli alcohol is a pure natural monomeric compound; very good large-area popularization and application prospects are realized in the anti-depression aspect.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to the application of patchouliol in the preparation of antidepressant drugs. Background technique [0002] Depression is an episodic form of manic depression. The typical symptoms are depression, slow thinking, and reduced speech and movement. Depression seriously affects the life and work of patients, and brings a heavy burden to the family and society. About 15% of patients with depression die of suicide. Depression has become the second largest disease burden in China, according to a joint study by the World Health Organization, the World Bank and Harvard University. [0003] At present, there are many treatment methods for depression, mainly Western medicine treatment, commonly used Western medicines include serotonin reuptake inhibitors, monoamine oxidase inhibitors, norepinephrine reuptake inhibitors and tricyclic antidepressants, but these drugs There ar...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P25/24
CPCA61K31/045A61P25/24
Inventor 黎玉翠苏子仁赖小平陈建南卓建仪
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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