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Application of sea-buckthorn seed oil to preparation of medicament for preventing and/or treating depression

A technology of seabuckthorn seed oil and depression, which is applied in application, food preparation, drug combination, etc., can solve the problems that have not been reported in the literature, and achieve the effect of low price, fast onset and strong pharmacological effect

Inactive Publication Date: 2012-09-12
山西盈科正欣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Seabuckthorn seed oil extracted from seabuckthorn seeds is rich in a variety of biologically active ingredients, including organic acids such as malic acid and oxalic acid, as well as active ingredients such as flavonoids, vitamin C, vitamin E, unsaturated fatty acids, and sterols. Cerebrovascular disease, hypertension, hyperlipidemia, and liver disease have good preventive or therapeutic effects, but the effect of seabuckthorn seed oil on nervous and mental system diseases, especially depression, has not been reported in the literature

Method used

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  • Application of sea-buckthorn seed oil to preparation of medicament for preventing and/or treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Mice forced swimming test

[0017] 1.1 Experimental instruments and reagents

[0018] Animal behavior video analysis system (Chengdu Taimeng Technology Co., Ltd.), thermometer, timer, plexiglass cylinder, 50mL graduated centrifuge tube (Corning Company), animal gavage device (Beijing Jiandaer Technology Co., Ltd.). Edible soybean salad oil (Arowana brand), seabuckthorn seed oil (Inner Mongolia Yuhangren High-tech Industry Co., Ltd.), venlafaxine hydrochloride (Chengdu Daxinan Pharmaceutical Co., Ltd.).

[0019] 1.2 Experimental animals and administration

[0020] Male ICR mice (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2006-0008), 18-22 g, were randomly divided into 5 groups after 1 week of adaptive feeding, with 12 mice in each group. The dose of venlafaxine is 0.05g / kg, and the high, medium and low doses of seabuckthorn seed oil are 2.0g / kg, 1.0g / kg and 0.5g / kg, and they are diluted with salad oil before...

Embodiment 2

[0032] Example 2 Mouse tail suspension test

[0033] 2.1 Experimental instruments and reagents

[0034] Animal behavior video analysis system (Chengdu Taimeng Technology Co., Ltd.), mouse tail suspension hook, timer, 50mL graduated centrifuge tube (Corning Company), animal gavage device (Beijing Giandel Technology Co., Ltd.). Edible soybean salad oil (Arowana brand), seabuckthorn seed oil (Inner Mongolia Yuhangren High-tech Industry Co., Ltd.), venlafaxine hydrochloride (Chengdu Daxinan Pharmaceutical Co., Ltd.).

[0035] 2.2 Experimental animals and administration

[0036] Experimental animals and administration are the same as in Example 1.

[0037] 2.3 Experimental method

[0038] 1 hour after the last administration, stick the mouse tail tip 1cm on the hanging hook, and hold the mouse and hang it into the observation box of the animal behavior video analysis system, record the desperate behavior of the mouse within 6 minutes, and analyze it for 4 minutes immobility tim...

Embodiment 3

[0044] Example 3 Mice open field test

[0045] 3.1 Experimental instruments and reagents

[0046] Animal behavior video analysis system (Chengdu Taimeng Technology Co., Ltd.), opening experiment box (self-made), 50mL graduated centrifuge tube (Corning Company), animal gavage device (Beijing Giandel Technology Co., Ltd.). Edible soybean salad oil (Arowana brand), seabuckthorn seed oil (Inner Mongolia Yuhangren High-tech Industry Co., Ltd.), venlafaxine hydrochloride (Chengdu Daxinan Pharmaceutical Co., Ltd.).

[0047] 3.2 Experimental animals and administration

[0048] Experimental animals and administration are the same as in Example 1.

[0049] 3.3 Experimental method

[0050] One hour after the last administration, the mice were placed in a 50×50×50 cm black open-field test box (the bottom was divided into 25 grids by white lines on average), and the animal behavior video analysis system was used to record the mouse’s autonomous behavior in the box within 4 minutes. Act...

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Abstract

The invention provides new application of sea-buckthorn seed oil extracted from sea-buckthorn seeds, i.e., application of the sea-buckthorn seed oil to preparation of a medicament or a health-care food for preventing and / or treating depression, and application of the sea-buckthorn seed oil serving as a raw material to preparation of the medicament or the health-care food for preventing and / or treating the depression. Test results prove that the immobility time in forced swimming tests of mice and tail suspension tests of the mice can be obviously reduced by the sea-buckthorn seed oil and the sea-buckthorn seed oil has an obvious depression suppression effect. The sea-buckthorn seed oil is a natural anti-depression effective substance which has the advantages of easiness and convenience in preparation, obvious effect, safety, reliability and easiness for industrial production. The sea-buckthorn seed oil can be prepared into formulations such as soft capsules, dropping pills and emulsion for anti-depression medicaments or health care foods.

Description

technical field [0001] The present invention relates to a new application of seabuckthorn seed oil, specifically the application of seabuckthorn seed oil in medicine or health food for preventing and / or treating depression. Background technique [0002] Depression is a common emotional mental illness, mainly manifested as significant and persistent low mood. Patients with mild depression manifest as a bad mood and loss of interest. In severe cases, they manifest as pessimism and despair. , often suicidal tendencies. Depression has the characteristics of high incidence rate, high relapse rate and high disability rate. The World Health Organization has listed it as one of the top ten serious diseases. With the rapid development of society and economy, the pace of life has accelerated, people's pressure has increased, and various emotional impacts have increased, resulting in an increase in the incidence of depression year by year. According to the prediction of WHO: by 2020,...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P25/24A23L1/29A61K131/00A23L33/00
Inventor 田俊生张丽增郭晓擎史碧云秦雪梅
Owner 山西盈科正欣生物科技有限公司
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